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Genetic determinants of virulence in...

Michigan State University.

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Genetic determinants of virulence in emerging viruses of natural felid populations.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Genetic determinants of virulence in emerging viruses of natural felid populations./
Author:	Brown, Meredith A.
Description:	117 p.
Notes:	Adviser: William W. Taylor.
Contained By:	Dissertation Abstracts International69-04B.
Subject:	Agriculture, Animal Pathology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3312666
ISBN:	9780549617587

Genetic determinants of virulence in emerging viruses of natural felid populations.
Brown, Meredith A.

Genetic determinants of virulence in emerging viruses of natural felid populations. - 117 p.

Adviser: William W. Taylor.

Thesis (Ph.D.)--Michigan State University, 2008.

Cats are a fascination. Whether our beloved pet cats providing companionship and play to our daily lives, or wild cheetahs questioning our choices as human impact continues to push wild species to extinction...cats inspire us to advance the fields of wildlife conservation and veterinary health.

ISBN: 9780549617587Subjects--Topical Terms:

1021764
Agriculture, Animal Pathology.

Genetic determinants of virulence in emerging viruses of natural felid populations.
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020 $a 9780549617587
035 $a (UMI)AAI3312666
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040 $a UMI $c UMI
100 1 $a Brown, Meredith A. $3 1031073
245 1 0 $a Genetic determinants of virulence in emerging viruses of natural felid populations.
300 $a 117 p.
500 $a Adviser: William W. Taylor.
500 $a Source: Dissertation Abstracts International, Volume: 69-04, Section: B, page: 2154.
502 $a Thesis (Ph.D.)--Michigan State University, 2008.
520 $a Cats are a fascination. Whether our beloved pet cats providing companionship and play to our daily lives, or wild cheetahs questioning our choices as human impact continues to push wild species to extinction...cats inspire us to advance the fields of wildlife conservation and veterinary health.
520 $a There is an additional developing rationale for studying disease ecology in the cat family. With the annotation of the complete cat genome, the field of comparative genomics has raised the prospects for developing the cat model as a comparative tool for human diseases. The members of the family felidae harbor many deadly infectious agents modeling human scourges including feline coronavirus, a relative to the human SARS virus; and feline leukemia virus and feline immunodeficiency virus, both retroviruses used as a model to study HIV AIDS and cancer in humans.
520 $a The diversity in habitat, behavior, and natural history of the 37 members of the cat family evolutionarily shape an array of host genetic determinant responses to these infectious diseases in terms of host-immune interactions in a natural setting. Here I use the tools of molecular genetics, virology, phylogenetics, and clinical pathology to better understand the mechanisms of pathogenesis in cat species infected with these deadly agents in nature. Through phylogenetic study, I describe the patterns of virulence in feline coronavirus infection (FCoV) in domestic cats, the emergence of feline leukemia virus (FeLV) in the previously naive Florida panther population, and the first occurrence of feline immunodeficiency virus (FIV) in Asia in the wild Mongolian Pallas' cat population. My results unseat several paradigms relating to pathogenic mechanisms and highlight the opportunities afforded by studying natural cat models of deadly scourges using the tools of molecular genetics. The rigorous sampling strategy employed in these studies, including isolating FeLV and FIV virus from nondomestic cat populations, and isolating both virulent and avirulent strains of FCoV from cats, is an important lesson for studying viral dynamics of emerging diseases in a natural context.
590 $a School code: 0128.
650 4 $a Agriculture, Animal Pathology. $3 1021764
650 4 $a Biology, Ecology. $3 1017726
650 4 $a Biology, Veterinary Science. $3 1021733
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710 2 $a Michigan State University. $3 676168
773 0 $t Dissertation Abstracts International $g 69-04B.
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790 1 0 $a Taylor, William W., $e advisor
791 $a Ph.D.
792 $a 2008
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3312666