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Elucidating the role of the alpha7 s...

East Tennessee State University.

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Elucidating the role of the alpha7 subunit of the nicotinic receptor in the etiology of schizophrenia.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Elucidating the role of the alpha7 subunit of the nicotinic receptor in the etiology of schizophrenia./
作者:	Chandley, Michelle J.
面頁冊數:	116 p.
附註:	Adviser: Barney Miller.
Contained By:	Dissertation Abstracts International69-12B.
標題:	Biology, Neuroscience. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoeng/servlet/advanced?query=3340418
ISBN:	9780549951315

Elucidating the role of the alpha7 subunit of the nicotinic receptor in the etiology of schizophrenia.
Chandley, Michelle J.

Elucidating the role of the alpha7 subunit of the nicotinic receptor in the etiology of schizophrenia. - 116 p.

Adviser: Barney Miller.

Thesis (Ph.D.)--East Tennessee State University, 2008.

The alpha7 subunit of the nicotinic receptor, a ligand gated ion channel with an affinity for nicotine, has long been implicated in the pathophysiology of schizophrenia due to the extremely high rate of smoking within the patient population. However, the exact role of the receptor has never fully been determined. In the following studies, various functions the receptor may assume in disease state are evaluated. There is a strong relationship between the immune system and schizophrenia, with the alpha7 subunit possibly serving as the link between the two. One of the following studies looks at the possibility of the receptor functioning as antigen in an autoimmune response. Blood sera of schizophrenic patients, as well as controls, were analyzed for the presence of antibodies to the alpha7 subunit of the nicotinic receptor. A sensitive ligand-based assay revealed schizophrenic patients could possess a pathogenic level of antibody that may exacerbate the degenerative nature of the disease, allowing for the possibility that receptor antibodies may serve as a contributing factor in the etiology of the disorder in at least a subset of patients. In other studies, the expression of the alpha7 receptor was investigated. Recombinant alpha7 receptor production has eluded researchers in non-mammalian species and this was the focus of our initial studies. In general, the lack of sufficient molecular recombinant techniques utilizing the receptor makes characterization of the alpha7 receptor and it's specific protein interactions difficult to evaluate. The regulatory mechanisms of the nicotinic receptor alpha7 subunit production and receptor formation have yet to be completely elucidated. Results in this investigation found a relationship between a functional CRE-element in the promoter region.

ISBN: 9780549951315Subjects--Topical Terms:

1017680
Biology, Neuroscience.

Elucidating the role of the alpha7 subunit of the nicotinic receptor in the etiology of schizophrenia.
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520 $a The alpha7 subunit of the nicotinic receptor, a ligand gated ion channel with an affinity for nicotine, has long been implicated in the pathophysiology of schizophrenia due to the extremely high rate of smoking within the patient population. However, the exact role of the receptor has never fully been determined. In the following studies, various functions the receptor may assume in disease state are evaluated. There is a strong relationship between the immune system and schizophrenia, with the alpha7 subunit possibly serving as the link between the two. One of the following studies looks at the possibility of the receptor functioning as antigen in an autoimmune response. Blood sera of schizophrenic patients, as well as controls, were analyzed for the presence of antibodies to the alpha7 subunit of the nicotinic receptor. A sensitive ligand-based assay revealed schizophrenic patients could possess a pathogenic level of antibody that may exacerbate the degenerative nature of the disease, allowing for the possibility that receptor antibodies may serve as a contributing factor in the etiology of the disorder in at least a subset of patients. In other studies, the expression of the alpha7 receptor was investigated. Recombinant alpha7 receptor production has eluded researchers in non-mammalian species and this was the focus of our initial studies. In general, the lack of sufficient molecular recombinant techniques utilizing the receptor makes characterization of the alpha7 receptor and it's specific protein interactions difficult to evaluate. The regulatory mechanisms of the nicotinic receptor alpha7 subunit production and receptor formation have yet to be completely elucidated. Results in this investigation found a relationship between a functional CRE-element in the promoter region.
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