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The amygdala modulates neuronal acti...

Boston University.

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The amygdala modulates neuronal activation in the hippocampus in response to spatial novelty: A rodent model of information processing deficits in schizophrenia.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	The amygdala modulates neuronal activation in the hippocampus in response to spatial novelty: A rodent model of information processing deficits in schizophrenia./
作者:	Sheth, Archana.
面頁冊數:	133 p.
附註:	Adviser: Howard Eichenbaum.
Contained By:	Dissertation Abstracts International69-05B.
標題:	Psychology, Behavioral. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoeng/servlet/advanced?query=3314073
ISBN:	9780549634775

The amygdala modulates neuronal activation in the hippocampus in response to spatial novelty: A rodent model of information processing deficits in schizophrenia.
Sheth, Archana.

The amygdala modulates neuronal activation in the hippocampus in response to spatial novelty: A rodent model of information processing deficits in schizophrenia. - 133 p.

Adviser: Howard Eichenbaum.

Thesis (Ph.D.)--Boston University, 2008.

Emerging evidence indicates that the amygdala and the hippocampus play an important role in the pathophysiology of major psychotic disorders. Abnormalities affecting these structures are postulated to contribute to deficits in cognitive and memory processing observed in schizophrenia. Consistent with this evidence, and with data indicating that the amygdala modulates hippocampal activity, animal studies have shown that disruption of amygdalar activity induces neurochemical changes in the hippocampus similar to those detected in schizophrenic subjects.

ISBN: 9780549634775Subjects--Topical Terms:

1017677
Psychology, Behavioral.

The amygdala modulates neuronal activation in the hippocampus in response to spatial novelty: A rodent model of information processing deficits in schizophrenia.
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245 1 4 $a The amygdala modulates neuronal activation in the hippocampus in response to spatial novelty: A rodent model of information processing deficits in schizophrenia.
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500 $a Source: Dissertation Abstracts International, Volume: 69-05, Section: B, page: 3313.
502 $a Thesis (Ph.D.)--Boston University, 2008.
520 $a Emerging evidence indicates that the amygdala and the hippocampus play an important role in the pathophysiology of major psychotic disorders. Abnormalities affecting these structures are postulated to contribute to deficits in cognitive and memory processing observed in schizophrenia. Consistent with this evidence, and with data indicating that the amygdala modulates hippocampal activity, animal studies have shown that disruption of amygdalar activity induces neurochemical changes in the hippocampus similar to those detected in schizophrenic subjects.
520 $a I tested the hypothesis that the amygdala may affect the response of the hippocampus to familiar and novel spatial environments. The GABA-A receptor antagonist, picrotoxin, was infused locally to disrupt amygdalar activity, while induction of the immediate early gene protein product Fos was used as a marker of neuronal activation in the hippocampus. Picrotoxin blocked the increase of Fos-IR in the hippocampus, seen in control subjects, in response to novel environments. Exploratory behavior in response to familiar and novel environments was unaltered by picrotoxin. These findings suggest that the amygdala modulates spatial information processing in the hippocampus and may affect encoding of specific environmental features, while complex behavioral responses to environment may be the result of broader neural circuits.
520 $a Hippocampal Fos-IR was mainly found in cells within the pyramidal layer and stratum oriens, where pyramidal neurons and interneurons that express calcium binding proteins parvalbumin and cholecystokinin occur. Dual color immunocytochemistry was used to test whether these interneurons are activated by spatial novelty. In control rats, fewer PVB/Fos-IR neurons were found in hippocampal subfields CA1/CA2 in the novel environment versus familiar (and intermediate) environments. Picrotoxin did not alter the number of PVB/Fos-IR neurons in familiar compared to novel environments. However, because (1) CCK-IR neurons in the hippocampus did not express Fos, and (2) the proportion of PVB/Fos-IR neurons compared to all Fos-IR neurons was small, it is likely that pyramidal neurons play a substantial role in response to spatial novelty.
520 $a Collectively, these findings indicate that the amygdala may contribute to schizophrenia-related changes in the hippocampus. Its effects on hippocampal interneurons and projection neurons may play an important role in shaping information processing about spatial novelty.
590 $a School code: 0017.
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