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Reliability and validity of an exper...

University of Massachusetts Lowell.

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Reliability and validity of an expert exposure assessment using log-linear models.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Reliability and validity of an expert exposure assessment using log-linear models./
作者:	Hunt, Phillip Reed.
面頁冊數:	116 p.
附註:	Adviser: David Kreibel.
Contained By:	Dissertation Abstracts International67-06B.
標題:	Biology, Biostatistics. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoeng/servlet/advanced?query=3221066
ISBN:	9780542744617

Reliability and validity of an expert exposure assessment using log-linear models.
Hunt, Phillip Reed.

Reliability and validity of an expert exposure assessment using log-linear models. - 116 p.

Adviser: David Kreibel.

Thesis (Sc.D.)--University of Massachusetts Lowell, 2006.

Workplace exposures represent an important risk factor for adult onset asthma. Estimates of the proportion of asthma that is work related range from 1-6% based on physician case reports, while community-based studies have found up to 36% of adult onset asthma attributable to occupational. The broad range of attributable risk estimates may be due, in part, to differing methods of assessing exposure. This research was designed to improve exposure assessment methodology for a large community-based study evaluating the role of occupational exposures in adult onset asthma.

ISBN: 9780542744617Subjects--Topical Terms:

1018416
Biology, Biostatistics.

Reliability and validity of an expert exposure assessment using log-linear models.
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520 $a Workplace exposures represent an important risk factor for adult onset asthma. Estimates of the proportion of asthma that is work related range from 1-6% based on physician case reports, while community-based studies have found up to 36% of adult onset asthma attributable to occupational. The broad range of attributable risk estimates may be due, in part, to differing methods of assessing exposure. This research was designed to improve exposure assessment methodology for a large community-based study evaluating the role of occupational exposures in adult onset asthma.
520 $a Expert panel assessment is considered the most feasible exposure assessment method for community based studies in occupational epidemiology. However, commonly used methods for assessing reliability and validity of expert assessments have significant limitations. This dissertation demonstrated a more practical approach to expert panel exposure assessment and developed a more rigorous method of analysis for evaluating the quality of the resulting data.
520 $a Experts assessed exposures to substances associated with occupational asthma based on telephone surveys of asthma cases and controls. Industrial hygiene walk-through inspections were used to provide independent validation data. Log-linear models of agreement were used to compare and combine information from experts and the workplace walk-through assessment. The validation ratings were incorporated into the log-linear agreement framework using a global (all experts and validation) and partial global (subsets of experts and validation) agreement structure. This agreement structure provides for flexibility in the determining the contribution of the expert and validation measures to the exposure probabilities that constitute the final exposure index.
520 $a The log-linear models of agreement demonstrated a moderate to high level of agreement among the expert panel and the validation data and a lack of differential misclassification. The methods developed in this study are a useful addition to occupational exposure assessment methodology, providing a sound statistical basis for assessing the reliability and validity of expert panel data and, further, providing a means to use the results of a validation study to apply measurement correction methods to the main body of exposure data.
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