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Changes in DPOAE and ABR responses f...

James Madison University.

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Changes in DPOAE and ABR responses following hair cell regeneration.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Changes in DPOAE and ABR responses following hair cell regeneration./
作者:	Belzner, Katharine Ann.
面頁冊數:	147 p.
附註:	Adviser: Brenda M. Ryals.
Contained By:	Dissertation Abstracts International69-11B.
標題:	Biology, Animal Physiology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoeng/servlet/advanced?query=3338639
ISBN:	9780549931904

Changes in DPOAE and ABR responses following hair cell regeneration.
Belzner, Katharine Ann.

Changes in DPOAE and ABR responses following hair cell regeneration. - 147 p.

Adviser: Brenda M. Ryals.

Thesis (Au.D.)--James Madison University, 2008.

In response to ototoxic insult birds show a temporary period of hair cell loss and regeneration, followed by considerable anatomical, physiological, and behavioral recovery (see Matsui and Ryals 2005 for Review). Investigators have examined the extent of recovery anatomically through scanning and transmission electron microscopy (Corwin, 1992; Cotanche, 1987a, 1987b; Rubel & Ryals, 1982; Ryals & Westbrook, 1994) and behaviorally (for review see Dooling 2008). Physiologic recovery has been assessed using otoacoustic emissions (Liberman, Zuo, & Guinan, 2004; Froymovich, Rebala, Salvi, & Rassael, 1995; Ipakchi, Kyin, & Saunders, 2005) and a variety of electrophysiologic measures (Katayama, 1985; Girod, Park, Park, & Durham, 2000; Woolley, Wissman, & Rubel, 2001). Combined, these studies have indicated that recovery is possible with lingering deficits in the higher frequencies. The current study was designed to differentially evaluate the contribution of peripheral and neural elements to recovery of auditory function after ototoxicity and hair cell regeneration.

ISBN: 9780549931904Subjects--Topical Terms:

1017835
Biology, Animal Physiology.

Changes in DPOAE and ABR responses following hair cell regeneration.
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100 1 $a Belzner, Katharine Ann. $3 1023977
245 1 0 $a Changes in DPOAE and ABR responses following hair cell regeneration.
300 $a 147 p.
500 $a Adviser: Brenda M. Ryals.
500 $a Source: Dissertation Abstracts International, Volume: 69-11, Section: B, page: 6671.
502 $a Thesis (Au.D.)--James Madison University, 2008.
520 $a In response to ototoxic insult birds show a temporary period of hair cell loss and regeneration, followed by considerable anatomical, physiological, and behavioral recovery (see Matsui and Ryals 2005 for Review). Investigators have examined the extent of recovery anatomically through scanning and transmission electron microscopy (Corwin, 1992; Cotanche, 1987a, 1987b; Rubel & Ryals, 1982; Ryals & Westbrook, 1994) and behaviorally (for review see Dooling 2008). Physiologic recovery has been assessed using otoacoustic emissions (Liberman, Zuo, & Guinan, 2004; Froymovich, Rebala, Salvi, & Rassael, 1995; Ipakchi, Kyin, & Saunders, 2005) and a variety of electrophysiologic measures (Katayama, 1985; Girod, Park, Park, & Durham, 2000; Woolley, Wissman, & Rubel, 2001). Combined, these studies have indicated that recovery is possible with lingering deficits in the higher frequencies. The current study was designed to differentially evaluate the contribution of peripheral and neural elements to recovery of auditory function after ototoxicity and hair cell regeneration.
520 $a Distortion product otoacoustic emissions (DPOAE) were used as a measure of functional integrity of the hair cell and the auditory brainstem response (ABR) as a measure of functional integrity of the auditory nerve. Tone-burst ABRs were recorded in chicks nine days post-hatch (P9) to confirm damage to the auditory system following 250mg/kg gentamicin treatment (injected at four days post-hatch, P4). DPOAEs were not measured at P9 due to anatomical restrictions of probe fit in the chick canal. DPOAE (2F1-F2: 1,500--3,500Hz) and tone-burst ABR (1,000--4,000Hz) were then measured two weeks following gentamicin injections; the time at which threshold shift has previously been reported as reaching asymptote (Saunders & Salvi, 2008). Threshold was defined as the lowest intensity level where a DPOAE was detected two standard deviations above the noise floor and the lowest intensity level at which Wave I was identified in an ABR.
520 $a Threshold sensitivity was found to be similar to normal controls for low and middle frequencies but was elevated at higher frequencies for both measures. These results suggest that peripheral abnormalities at the level of the hair cell contribute to the small but permanent threshold shift at high frequencies.
590 $a School code: 1357.
650 4 $a Biology, Animal Physiology. $3 1017835
650 4 $a Health Sciences, Audiology. $3 1018138
690 $a 0300
690 $a 0433
710 2 $a James Madison University. $3 1023976
773 0 $t Dissertation Abstracts International $g 69-11B.
790 $a 1357
790 1 0 $a Ryals, Brenda M., $e advisor
791 $a Au.D.
792 $a 2008
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoeng/servlet/advanced?query=3338639