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Effects of ingesting carbohydrate an...

Baylor University., Education.

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Effects of ingesting carbohydrate and branched-chain amino acids on markers of skeletal muscle protein synthesis of the insulin-PI3K-mTOR signal transduction pathways in response to a bout of heavy resistance exercise.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Effects of ingesting carbohydrate and branched-chain amino acids on markers of skeletal muscle protein synthesis of the insulin-PI3K-mTOR signal transduction pathways in response to a bout of heavy resistance exercise./
Author:	Ferreira, Maria Pontes.
Description:	119 p.
Notes:	Advisers: Richard B. Kreider; Darryn S. Willoughby; Rafer S. Lutz.
Contained By:	Dissertation Abstracts International69-07B.
Subject:	Health Sciences, Nutrition. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoeng/servlet/advanced?query=3316059
ISBN:	9780549684367

Effects of ingesting carbohydrate and branched-chain amino acids on markers of skeletal muscle protein synthesis of the insulin-PI3K-mTOR signal transduction pathways in response to a bout of heavy resistance exercise.
Ferreira, Maria Pontes.

Effects of ingesting carbohydrate and branched-chain amino acids on markers of skeletal muscle protein synthesis of the insulin-PI3K-mTOR signal transduction pathways in response to a bout of heavy resistance exercise. - 119 p.

Advisers: Richard B. Kreider; Darryn S. Willoughby; Rafer S. Lutz.

Thesis (Ph.D.)--Baylor University, 2008.

Purpose. To determine if activity of the MAPK-ERK or PI3K-mTOR insulin signaling pathway is increased in response to an acute lower body resistance exercise (RE) bout and supplemental BCAA + CHO or CHO ingestion. Methods. 27 recreationally trained males (20.9 y; 81.8 kg) were randomly assigned to a group: BCAA (30g) + CHO (350g), CHO (350g), or placebo CON. Participants performed 4 sets of leg press and extensions at 80% 1RM to failure. Supplements were ingested at 3 time points: 30 min prior to RE, and immediately pre- and post-RE. Venous blood was sampled at baseline (Pre-); 30 min post-RE; 2 h post-RE, and 6 h post-RE for serum glucose and insulin. Blood variables were transformed to percent change values and analyzed by a 3 x 4 repeated measures MANOVA. Muscle biopsies were obtained at baseline, 30 min post-RE, 2 h post-RE, and 6 h post-RE for ERK1/2, IRS, Akt/PKB, GSK, mTOR, 4E-BPI, and p70S6K. Skeletal muscle variables were transformed to percent change values and analyzed by 3 x 4 repeated measures MANOVA. Univariate ANOVAs were utilized as follow-up tests to the MANOVA for select variables. Results. MANOVA results demonstrate a significant group x time interaction for insulin and glucose (p<.05). Despite a nearly 3-fold increase of insulin over fasting baseline measures in the CHO groups as compared to the placebo group, neither BCAA + CHO or CHO significantly increased any of the muscle variables. Univariate analysis demonstrated a significant group x time interaction for Akt/PKB phosphorylation (p=.039), suggesting a group effect. Several muscle variables demonstrated by MANOVA a significant time effect: IRS (p=.054); Akt/PKB (p=.011); ERK1/2 (p=.026); p70S6K (p=.038). A time trend for mTOR (p=.089) was noted. No significant effects were found for GSK and 4E-BP above baseline or among groups. Summary. Results indicate that RE, not BCAA + CHO or CHO, increased the phosphorylation status of IRS, Akt/PKB, p70S6K, and ERK above baseline levels (p<.05) with a group x time interaction trend for Akt/PKB and a time trend for mTOR activation. Phosphorylation of GSK and 4E-BP were not influenced by the RE and supplementation protocol.

ISBN: 9780549684367Subjects--Topical Terms:

1017801
Health Sciences, Nutrition.

Effects of ingesting carbohydrate and branched-chain amino acids on markers of skeletal muscle protein synthesis of the insulin-PI3K-mTOR signal transduction pathways in response to a bout of heavy resistance exercise.
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020 $a 9780549684367
035 $a (UMI)AAI3316059
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100 1 $a Ferreira, Maria Pontes. $3 1023853
245 1 0 $a Effects of ingesting carbohydrate and branched-chain amino acids on markers of skeletal muscle protein synthesis of the insulin-PI3K-mTOR signal transduction pathways in response to a bout of heavy resistance exercise.
300 $a 119 p.
500 $a Advisers: Richard B. Kreider; Darryn S. Willoughby; Rafer S. Lutz.
500 $a Source: Dissertation Abstracts International, Volume: 69-07, Section: B, page: 4097.
502 $a Thesis (Ph.D.)--Baylor University, 2008.
520 $a Purpose. To determine if activity of the MAPK-ERK or PI3K-mTOR insulin signaling pathway is increased in response to an acute lower body resistance exercise (RE) bout and supplemental BCAA + CHO or CHO ingestion. Methods. 27 recreationally trained males (20.9 y; 81.8 kg) were randomly assigned to a group: BCAA (30g) + CHO (350g), CHO (350g), or placebo CON. Participants performed 4 sets of leg press and extensions at 80% 1RM to failure. Supplements were ingested at 3 time points: 30 min prior to RE, and immediately pre- and post-RE. Venous blood was sampled at baseline (Pre-); 30 min post-RE; 2 h post-RE, and 6 h post-RE for serum glucose and insulin. Blood variables were transformed to percent change values and analyzed by a 3 x 4 repeated measures MANOVA. Muscle biopsies were obtained at baseline, 30 min post-RE, 2 h post-RE, and 6 h post-RE for ERK1/2, IRS, Akt/PKB, GSK, mTOR, 4E-BPI, and p70S6K. Skeletal muscle variables were transformed to percent change values and analyzed by 3 x 4 repeated measures MANOVA. Univariate ANOVAs were utilized as follow-up tests to the MANOVA for select variables. Results. MANOVA results demonstrate a significant group x time interaction for insulin and glucose (p<.05). Despite a nearly 3-fold increase of insulin over fasting baseline measures in the CHO groups as compared to the placebo group, neither BCAA + CHO or CHO significantly increased any of the muscle variables. Univariate analysis demonstrated a significant group x time interaction for Akt/PKB phosphorylation (p=.039), suggesting a group effect. Several muscle variables demonstrated by MANOVA a significant time effect: IRS (p=.054); Akt/PKB (p=.011); ERK1/2 (p=.026); p70S6K (p=.038). A time trend for mTOR (p=.089) was noted. No significant effects were found for GSK and 4E-BP above baseline or among groups. Summary. Results indicate that RE, not BCAA + CHO or CHO, increased the phosphorylation status of IRS, Akt/PKB, p70S6K, and ERK above baseline levels (p<.05) with a group x time interaction trend for Akt/PKB and a time trend for mTOR activation. Phosphorylation of GSK and 4E-BP were not influenced by the RE and supplementation protocol.
590 $a School code: 0014.
650 4 $a Health Sciences, Nutrition. $3 1017801
650 4 $a Health Sciences, Recreation. $3 1018003
690 $a 0570
690 $a 0575
710 2 $a Baylor University. $b Education. $3 1023846
773 0 $t Dissertation Abstracts International $g 69-07B.
790 $a 0014
790 1 0 $a Cooke, Matthew B. $e committee member
790 1 0 $a Greenwood, Lori D. $e committee member
790 1 0 $a Greenwood, Mike $e committee member
790 1 0 $a Jas, Gouri $e committee member
790 1 0 $a Kreider, Richard B., $e advisor
790 1 0 $a Lutz, Rafer S., $e advisor
790 1 0 $a Willoughby, Darryn S., $e advisor
791 $a Ph.D.
792 $a 2008
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoeng/servlet/advanced?query=3316059