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Assessment and prediction of iron st...

University of California, Davis.

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Assessment and prediction of iron status and effects of iron supplementation with vs without a meal on iron, zinc and copper status and markers of oxidative stress.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Assessment and prediction of iron status and effects of iron supplementation with vs without a meal on iron, zinc and copper status and markers of oxidative stress./
作者:	Yang, Zhenyu.
面頁冊數:	162 p.
附註:	Source: Dissertation Abstracts International, Volume: 69-05, Section: B, page: 2921.
Contained By:	Dissertation Abstracts International69-05B.
標題:	Health Sciences, Epidemiology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoeng/servlet/advanced?query=3317980
ISBN:	9780549666110

Assessment and prediction of iron status and effects of iron supplementation with vs without a meal on iron, zinc and copper status and markers of oxidative stress.
Yang, Zhenyu.

Assessment and prediction of iron status and effects of iron supplementation with vs without a meal on iron, zinc and copper status and markers of oxidative stress. - 162 p.

Source: Dissertation Abstracts International, Volume: 69-05, Section: B, page: 2921.

Thesis (Ph.D.)--University of California, Davis, 2008.

Iron deficiency (ID) is highly prevalent globally, but potential risks associated with iron supplementation have raised concerns about how to control ID. In a series of studies, we examined indicators and predictors of iron status and investigated potential adverse effects of iron supplementation.

ISBN: 9780549666110Subjects--Topical Terms:

1019544
Health Sciences, Epidemiology.

Assessment and prediction of iron status and effects of iron supplementation with vs without a meal on iron, zinc and copper status and markers of oxidative stress.
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245 1 0 $a Assessment and prediction of iron status and effects of iron supplementation with vs without a meal on iron, zinc and copper status and markers of oxidative stress.
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500 $a Source: Dissertation Abstracts International, Volume: 69-05, Section: B, page: 2921.
502 $a Thesis (Ph.D.)--University of California, Davis, 2008.
520 $a Iron deficiency (ID) is highly prevalent globally, but potential risks associated with iron supplementation have raised concerns about how to control ID. In a series of studies, we examined indicators and predictors of iron status and investigated potential adverse effects of iron supplementation.
520 $a We found that plasma ferritin concentration alone provides a good approximation of total body iron reserves, estimated by the ratio of transferrin receptor/ferritin, in several age groups, based on high correlations (r > 0.95) and good sensitivity and specificity (> 0.90) among individuals with non-elevated C-reactive protein (n = 1189).
520 $a In fully breastfed infants (n=404) at 6 mo of age, we found that the significant predictors of low ferritin (20% overall) were immediate umbilical cord clamping (AOR 4.5), male sex (AOR 4.0) and birth weight between 2500 - 2999 g (AOR 2.3). The predictors of ID plus anemia (8% overall) were male sex (AOR 7.2), birth weight between 2500 - 2999 g (AOR 3.0), and weight gain since birth above the median (AOR 3.1).
520 $a We assessed acute effects on plasma iron, non-transferrin bound iron (NTBI) and isoprostane (a marker of oxidative stress) of an iron supplement given with or without rice porridge, using a cross-over design with a one-week washout period. Within 4 h after ingestion of 45 mg iron as FeSO4, plasma iron concentrations were significantly greater when given without a meal than with a meal. The increase in plasma iron was greater for subjects with low vs. high iron stores regardless of treatment. Plasma NTBI concentrations were marginally greater for subjects with high iron stores than for those with low iron stores, but they did not increase after ingestion of iron supplements. Plasma isoprostane concentrations did not differ by treatment or increase after ingestion of the iron supplement. The results suggest that giving iron with a meal limits iron uptake, particularly by subjects with high iron stores.
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