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Ultrasound induced silk-hyaluronan (...

Tufts University., Biomedical Engineering.

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Ultrasound induced silk-hyaluronan (HA) blend hydrogel for biomedical application.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Ultrasound induced silk-hyaluronan (HA) blend hydrogel for biomedical application./
作者:	Hu, Xiao.
面頁冊數:	82 p.
附註:	Adviser: David Kaplan.
Contained By:	Masters Abstracts International47-05.
標題:	Biophysics, General. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoeng/servlet/advanced?query=1463878
ISBN:	9781109118155

Ultrasound induced silk-hyaluronan (HA) blend hydrogel for biomedical application.
Hu, Xiao.

Ultrasound induced silk-hyaluronan (HA) blend hydrogel for biomedical application. - 82 p.

Adviser: David Kaplan.

Thesis (M.S.)--Tufts University, 2009.

A novel method to physically crosslink biomaterials into a silk fibroin hydrogel network is reported. Through the mechanism of ultrasound sonication induced gelation of silk fibroin aqueous solution, blended uncrosslinked long chain biomaterials can be entrapped in the silk fibroin hydrogel system. Uncrosslinked hyaluronic acid (HA) was used and formed into silk/HA blended hydrogels with different mixing ratios, forming homogenous materials with stable swelling behavior when the HA content was less than 40 wt%. Differential scanning calorimetry (DSC), temperature modulated DSC (TMDSC) and thermal gravimetric analysis (TGA) showed that well-blend silk/HA hydrogel systems were formed without macrophase separation in the system. Fourier transform infrared spectroscopy (FTIR) was used to determine the fraction of secondary structures from the Amide I region of silk fibroin protein by spectral subtraction and Fourier-self-deconvolution (FSD). The results show that the beta sheet crystal fraction inside silk fibroin protein increased with increase of the HA component in the hydrogel scaffolds, which results in a stable high crystallnity (30&sim;35 wt%) in all blend hydrogel scaffolds, and indicated silk crystals were formed to trap the HA chains in the crosslinked region of the silk/HA hydrogel structures. Scanning electron microscopy (SEM) confirmed this prediction and showed different porous scaffold morphologies for the silk/HA hydrogel systems. The blend hydrogels could be useful for biomedical applications due to the biocompatibility of the components to the widespread need for hydrogel systems in medicine.

ISBN: 9781109118155Subjects--Topical Terms:

1019105
Biophysics, General.

Ultrasound induced silk-hyaluronan (HA) blend hydrogel for biomedical application.
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520 $a A novel method to physically crosslink biomaterials into a silk fibroin hydrogel network is reported. Through the mechanism of ultrasound sonication induced gelation of silk fibroin aqueous solution, blended uncrosslinked long chain biomaterials can be entrapped in the silk fibroin hydrogel system. Uncrosslinked hyaluronic acid (HA) was used and formed into silk/HA blended hydrogels with different mixing ratios, forming homogenous materials with stable swelling behavior when the HA content was less than 40 wt%. Differential scanning calorimetry (DSC), temperature modulated DSC (TMDSC) and thermal gravimetric analysis (TGA) showed that well-blend silk/HA hydrogel systems were formed without macrophase separation in the system. Fourier transform infrared spectroscopy (FTIR) was used to determine the fraction of secondary structures from the Amide I region of silk fibroin protein by spectral subtraction and Fourier-self-deconvolution (FSD). The results show that the beta sheet crystal fraction inside silk fibroin protein increased with increase of the HA component in the hydrogel scaffolds, which results in a stable high crystallnity (30&sim;35 wt%) in all blend hydrogel scaffolds, and indicated silk crystals were formed to trap the HA chains in the crosslinked region of the silk/HA hydrogel structures. Scanning electron microscopy (SEM) confirmed this prediction and showed different porous scaffold morphologies for the silk/HA hydrogel systems. The blend hydrogels could be useful for biomedical applications due to the biocompatibility of the components to the widespread need for hydrogel systems in medicine.
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