東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

Neuroendocrine effects of peripubert...

University of Massachusetts Amherst., Neuroscience & Behavior.

FindBook

Google Book

Amazon

博客來

Neuroendocrine effects of peripubertal stress exposure in the female mouse.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Neuroendocrine effects of peripubertal stress exposure in the female mouse./
作者:	Laroche, Julie.
面頁冊數:	330 p.
附註:	Adviser: Jeffrey D. Blaustein.
Contained By:	Dissertation Abstracts International69-07B.
標題:	Biology, Neuroscience. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoeng/servlet/advanced?query=3315522
ISBN:	9780549664024

Neuroendocrine effects of peripubertal stress exposure in the female mouse.
Laroche, Julie.

Neuroendocrine effects of peripubertal stress exposure in the female mouse. - 330 p.

Adviser: Jeffrey D. Blaustein.

Thesis (Ph.D.)--University of Massachusetts Amherst, 2008.

The peripubertal period is a period during which significant brain re-organization occurs, and during which changes in the neuroendocrine milieu normally lead to the onset of fertility. Shipping female mice during the peripubertal period causes a long-lasting behavioral defeminization of feminine sexual behavior. Because shipping is a stressor, it was suggested that peripubertal stress exposure might interfere with the regulation of feminine sexual behaviors in adult female mice. As a result, the goal of this research was to examine the effects of peripubertal stress exposure on neuroendocrine regulation of the hypothalamo-pituitary-gonadal (HPG) and the hypothalamo-pituitary-adrenal (HPA) axis. However, although peripubertally exposing female mice to shipment stress caused a significant decrease in sexual receptivity, peripubertal exposure to restraint stress, food deprivation, social stress and instability, or multiple stressors (heat, light, and restraint) did not decrease sexual receptivity during adulthood. Only exposure to a high dose of bacterial endotoxin during the peripubertal period duplicated the defeminizing effect of shipping during the peripubertal period on adult mouse feminine sexual behavior. Interestingly, significant long-term effects of peripubertal stress exposure were also observed in the regulation of the HPA axis, where exposure to peripubertal shipping and LPS led to blunted stress-induced corticosterone responses in adult female mice. Peripubertal exposure to shipping and LPS had long-lasting effects on steroid receptor expression in brain areas relevant to female reproduction. Nevertheless, peripubertal exposure to LPS did not interfere with the ability of estradiol to induce the release of LH. Moreover, although peripubertal exposure to shipping decreased masculine sexual behavior in male, but not female, mice, peripubertal exposure to LPS was without effect on masculine sexual behavior. These results suggest that exposure to some, but not all, peripubertal stressors can induce long-lasting changes in reproductive behaviors, as well as changes in the expression of sex steroid receptors known to regulate these behaviors.

ISBN: 9780549664024Subjects--Topical Terms:

1017680
Biology, Neuroscience.

Neuroendocrine effects of peripubertal stress exposure in the female mouse.
LDR:03311nam 2200337 a 45 001 856701
005 20100709
008 100709s2008 ||||||||||||||||| ||eng d
020 $a 9780549664024
035 $a (UMI)AAI3315522
035 $a AAI3315522
040 $a UMI $c UMI
100 1 $a Laroche, Julie. $3 1023549
245 1 0 $a Neuroendocrine effects of peripubertal stress exposure in the female mouse.
300 $a 330 p.
500 $a Adviser: Jeffrey D. Blaustein.
500 $a Source: Dissertation Abstracts International, Volume: 69-07, Section: B, page: 4006.
502 $a Thesis (Ph.D.)--University of Massachusetts Amherst, 2008.
520 $a The peripubertal period is a period during which significant brain re-organization occurs, and during which changes in the neuroendocrine milieu normally lead to the onset of fertility. Shipping female mice during the peripubertal period causes a long-lasting behavioral defeminization of feminine sexual behavior. Because shipping is a stressor, it was suggested that peripubertal stress exposure might interfere with the regulation of feminine sexual behaviors in adult female mice. As a result, the goal of this research was to examine the effects of peripubertal stress exposure on neuroendocrine regulation of the hypothalamo-pituitary-gonadal (HPG) and the hypothalamo-pituitary-adrenal (HPA) axis. However, although peripubertally exposing female mice to shipment stress caused a significant decrease in sexual receptivity, peripubertal exposure to restraint stress, food deprivation, social stress and instability, or multiple stressors (heat, light, and restraint) did not decrease sexual receptivity during adulthood. Only exposure to a high dose of bacterial endotoxin during the peripubertal period duplicated the defeminizing effect of shipping during the peripubertal period on adult mouse feminine sexual behavior. Interestingly, significant long-term effects of peripubertal stress exposure were also observed in the regulation of the HPA axis, where exposure to peripubertal shipping and LPS led to blunted stress-induced corticosterone responses in adult female mice. Peripubertal exposure to shipping and LPS had long-lasting effects on steroid receptor expression in brain areas relevant to female reproduction. Nevertheless, peripubertal exposure to LPS did not interfere with the ability of estradiol to induce the release of LH. Moreover, although peripubertal exposure to shipping decreased masculine sexual behavior in male, but not female, mice, peripubertal exposure to LPS was without effect on masculine sexual behavior. These results suggest that exposure to some, but not all, peripubertal stressors can induce long-lasting changes in reproductive behaviors, as well as changes in the expression of sex steroid receptors known to regulate these behaviors.
590 $a School code: 0118.
650 4 $a Biology, Neuroscience. $3 1017680
650 4 $a Biology, Physiology. $3 1017816
650 4 $a Health Sciences, General. $3 1017817
690 $a 0317
690 $a 0566
690 $a 0719
710 2 $a University of Massachusetts Amherst. $b Neuroscience & Behavior. $3 1023548
773 0 $t Dissertation Abstracts International $g 69-07B.
790 $a 0118
790 1 0 $a Bittman, Eric L. $e committee member
790 1 0 $a Blaustein, Jeffrey D., $e advisor
790 1 0 $a Forger, Nancy G. $e committee member
790 1 0 $a Hayes, UnJa L. $e committee member
790 1 0 $a Powers, Sally I. $e committee member
791 $a Ph.D.
792 $a 2008
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoeng/servlet/advanced?query=3315522