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The effect of nutritional deprivatio...

The Johns Hopkins University.

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The effect of nutritional deprivation on whole body metabolism and lung structure.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	The effect of nutritional deprivation on whole body metabolism and lung structure./
作者:	Bishai, John M.
面頁冊數:	135 p.
附註:	Adviser: Wayne Mitzner.
Contained By:	Dissertation Abstracts International68-11B.
標題:	Biology, Physiology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoeng/servlet/advanced?query=3288432
ISBN:	9780549311676

The effect of nutritional deprivation on whole body metabolism and lung structure.
Bishai, John M.

The effect of nutritional deprivation on whole body metabolism and lung structure. - 135 p.

Adviser: Wayne Mitzner.

Thesis (Ph.D.)--The Johns Hopkins University, 2008.

Severe calorie restriction (CR) has been suggested to cause acute changes in lung acinar structure. This has led to the notion of "nutritional emphysema," which has been implicated in human anorexic patients. Although studies exist, few have completely described both the mechanics and lung structural changes in one concerted study. In the present study, we measured changes in lung mechanics and histologic changes while monitoring metabolic related data in all three mouse strains. Male C57B1/6J (B6), C3He/HeJ (C3), and C3H/HeOUJ (OUJ) mice (10-12 weeks old) were divided into 3 groups: control, CR, and CR with refeeding. During CR, each mouse was given 1/3 their normal food consumption for either 2 or 3 weeks. CR lungs became stiffer with increased resistance while total lung capacity at 35 cmH2O was decreased. These mechanical changes were reversed during refeeding. Histology of the postmortem fixed lungs showed no changes in the mean alveolar chord lengths with calorie restriction. Although the baseline mechanics and alveolar size were quantitatively different in the three strains, all strains showed similar qualitative changes during the starvation and refeeding periods. Thus, neither the mechanics nor the histology shows any evidence of emphysema-like changes in response to severe calorie restriction.

ISBN: 9780549311676Subjects--Topical Terms:

1017816
Biology, Physiology.

The effect of nutritional deprivation on whole body metabolism and lung structure.
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