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Further characterization of the reti...

Michigan State University.

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Further characterization of the retinopathy, globe enlarged (rge) chicken.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Further characterization of the retinopathy, globe enlarged (rge) chicken./
作者:	Shaw, Gillian Curtis.
面頁冊數:	153 p.
附註:	Adviser: Simon M. Petersen-Jones.
Contained By:	Masters Abstracts International46-02.
標題:	Health Sciences, Ophthalmology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1448528
ISBN:	9780549254973

Further characterization of the retinopathy, globe enlarged (rge) chicken.
Shaw, Gillian Curtis.

Further characterization of the retinopathy, globe enlarged (rge) chicken. - 153 p.

Adviser: Simon M. Petersen-Jones.

Thesis (M.S.)--Michigan State University, 2007.

Previous work has shown that retinopathy, globe enlarged (rge) affected chicks eventually become functionally blind and subsequently develop globe enlargement. Electroretinographic (ERG) abnormalities include increased thresholds, a "supernormal b-wave" in response to brighter flashes, a lack of oscillatory potentials and ERG responses that are present long after functional blindness. Screening of several positional candidate genes was performed; however, another research group identified the causative mutation in GNB3, the beta subunit of a heterotrimeric G-protein involved in phototransduction in cone photoreceptors. Pharmacological dissection of the rge ERG using aspartate, APB and PDA demonstrated decreased cone sensitivity but also suggested abnormalities of the inner retinal ON and OFF pathways. GNB3 has not definitively been shown to be involved in inner retinal pathways, however these ERG results suggest it may play a role in such pathways. Preliminary immunohistochemistry identified GNB3 immunoreactivity in cone cell bodies, outer plexiform layer synaptic terminals and a population of cells in the inner nuclear and ganglion cell layers in normal chicken retina. These data suggest GNB3 may also be important in inner retinal signaling. Further studies are necessary to explore this hypothesis.

ISBN: 9780549254973Subjects--Topical Terms:

1019445
Health Sciences, Ophthalmology.

Further characterization of the retinopathy, globe enlarged (rge) chicken.
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