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Molecular characterization of animal...

Georgetown University., Tumor Biology.

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Molecular characterization of animal models of pheochromocytoma.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Molecular characterization of animal models of pheochromocytoma./
作者:	Lai, Edwin W.
面頁冊數:	110 p.
附註:	Advisers: Karel Pacak; Chris Albanese.
Contained By:	Dissertation Abstracts International70-03B.
標題:	Biology, Animal Physiology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3352226
ISBN:	9781109086478

Molecular characterization of animal models of pheochromocytoma.
Lai, Edwin W.

Molecular characterization of animal models of pheochromocytoma. - 110 p.

Advisers: Karel Pacak; Chris Albanese.

Thesis (Ph.D.)--Georgetown University, 2009.

Pheochromocytoma remains one of the most misunderstood and under-diagnosed human cancers. Tumors primarily arise from chromaffin cells of the adrenal medulla, but also from extra-adrenal sympathetic ganglia termed "extra-adrenal paraganglioma." Despite advances in diagnosis and localization of pheochromocytoma, the majority of patients with pheochromocytoma have no known genetic background and the etiology of these tumors is unknown. Another difficulty is that there are currently no biochemical or molecular markers to predict metastatic disease. Metastatic disease is only characterized by localization of tumors where chromaffin cells are normally absent.

ISBN: 9781109086478Subjects--Topical Terms:

1017835
Biology, Animal Physiology.

Molecular characterization of animal models of pheochromocytoma.
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100 1 $a Lai, Edwin W. $3 1021858
245 1 0 $a Molecular characterization of animal models of pheochromocytoma.
300 $a 110 p.
500 $a Advisers: Karel Pacak; Chris Albanese.
500 $a Source: Dissertation Abstracts International, Volume: 70-03, Section: B, page: 1603.
502 $a Thesis (Ph.D.)--Georgetown University, 2009.
520 $a Pheochromocytoma remains one of the most misunderstood and under-diagnosed human cancers. Tumors primarily arise from chromaffin cells of the adrenal medulla, but also from extra-adrenal sympathetic ganglia termed "extra-adrenal paraganglioma." Despite advances in diagnosis and localization of pheochromocytoma, the majority of patients with pheochromocytoma have no known genetic background and the etiology of these tumors is unknown. Another difficulty is that there are currently no biochemical or molecular markers to predict metastatic disease. Metastatic disease is only characterized by localization of tumors where chromaffin cells are normally absent.
520 $a Significant emphasis has recently been placed on developing and testing novel experimental therapeutic options, especially targeted therapy which exploit specific biochemical properties of this tumor. However, unlike other diseases, few biologically relevant animal models have been developed and no human pheochromocytoma cell lines have been successfully established. Therefore, the paucity of effective and accurate preclinical models remains an obstacle.
520 $a Enhanced or dys-regulated signaling by the receptor tyrosine kinase ErbB-2 (HER2/Neu) has been associated with a wide variety of diseases. In our studies, we implicated ErbB-2 expression may be linked to pheochromocytoma and enhanced ErbB-2 signaling may play an important role in the pathogenesis of this tumor. We also identify prognostic markers such as positive nuclear cyclin D1 staining or loss of 4E-BP1, and associate signal pathway targets for small molecule inhibition, such as mTOR.
520 $a In vitro studies for pheochromocytoma are often performed in the mouse pheochromocytoma cell line. Our group established in vivo animal models generated by subcutaneous or tail vein injecting mouse pheochomocytoma cells. These models are useful, especially for studying metastatic pheochromocytoma. Microarray analysis of liver metastases and subcutaneous tumors revealed differential gene expression. In conjunction with human microarray, potential target genes have been identified. Increased expression of interleukin (IL)-13Ralpha2 in pheochromocytoma was identified through human and mouse microarray analysis as a potential cell surface receptor target for immunotoxins. To target pheochromocytoma cells overexpressing IL-13Ralpha2, an immunotoxin consisting of IL-13 and truncated Pseudomonas exotoxin A (IL-13PE) was tested in vitro and in vivo. IL-13PE directed therapy provides a unique opportunity for cancer therapy.
590 $a School code: 0076.
650 4 $a Biology, Animal Physiology. $3 1017835
650 4 $a Biology, Cell. $3 1017686
650 4 $a Health Sciences, Oncology. $3 1018566
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710 2 $a Georgetown University. $b Tumor Biology. $3 1021857
773 0 $t Dissertation Abstracts International $g 70-03B.
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790 1 0 $a Albanese, Chris, $e advisor
790 1 0 $a Eisenhofer, Graeme $e committee member
790 1 0 $a Hilakivi-Clarke, Leena A. $e committee member
790 1 0 $a Mueller, Susette C. $e committee member
790 1 0 $a Pacak, Karel, $e advisor
790 1 0 $a Riegel, Anna T. $e committee member
791 $a Ph.D.
792 $a 2009
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3352226