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Charged ultrafiltration membranes fo...

The University of Wisconsin - Madison.

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Charged ultrafiltration membranes for whey protein fractionation.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Charged ultrafiltration membranes for whey protein fractionation./
Author:	Bhushan, Shanti.
Description:	228 p.
Notes:	Adivser: Mark R. Etzel.
Contained By:	Dissertation Abstracts International69-09B.
Subject:	Agriculture, Food Science and Technology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3327973
ISBN:	9780549799658

Charged ultrafiltration membranes for whey protein fractionation.
Bhushan, Shanti.

Charged ultrafiltration membranes for whey protein fractionation. - 228 p.

Adivser: Mark R. Etzel.

Thesis (Ph.D.)--The University of Wisconsin - Madison, 2008.

This work showed that charged membranes can be used to successfully fractionate similarly sized proteins from whey and also provided a theoretical basis for data analysis and scale up.

ISBN: 9780549799658Subjects--Topical Terms:

1017813
Agriculture, Food Science and Technology.

Charged ultrafiltration membranes for whey protein fractionation.
LDR:03257nam 2200301 a 45 001 854350
005 20100702
008 100702s2008 ||||||||||||||||| ||eng d
020 $a 9780549799658
035 $a (UMI)AAI3327973
035 $a AAI3327973
040 $a UMI $c UMI
100 1 $a Bhushan, Shanti. $3 1020700
245 1 0 $a Charged ultrafiltration membranes for whey protein fractionation.
300 $a 228 p.
500 $a Adivser: Mark R. Etzel.
500 $a Source: Dissertation Abstracts International, Volume: 69-09, Section: B, page: 5113.
502 $a Thesis (Ph.D.)--The University of Wisconsin - Madison, 2008.
520 $a This work showed that charged membranes can be used to successfully fractionate similarly sized proteins from whey and also provided a theoretical basis for data analysis and scale up.
520 $a Although ultrafiltration offers a number of advantages for the concentration of proteins, its use for protein fractionation is limited to the separation of proteins of widely different molecular weights. Charged ultrafiltration membrane technology is a relatively new concept which promises to widen the use of ultrafiltration for the concentration and fractionation of proteins. The central hypothesis of this research is that charged ultrafiltration membranes can be used to fractionate bioactive whey proteins. This hypothesis is based on the fact that although the different whey proteins do not differ greatly in molecular weight, the isoelectric points are markedly different, and hence membrane charge and protein charge can be utilized to enhance the extent of separation.
520 $a The ultrafiltration experiments were performed for the separation of different whey proteins. In particular, the research targeted the acidic whey protein glycomacropeptide. The separation achieved was enhanced by using charged ultrafiltration membranes and by optimization of the physicochemical properties of the solution (pH and conductivity) and operating conditions of the process (flux and mass transfer). Both dead-end and crossflow modes of operations were examined. The data were fitted using the stagnant film model that relates the observed sieving coefficient to flux, mass transfer coefficient, and concentration driving force. The concept of constant concentration polarization was also used to maintain a constant concentration of protein at the membrane surface in order to minimize the loss of protein through the membrane during the protein concentration experiments.
520 $a Charged membranes enhanced the selectivity of separation of glycomacropeptide from the other proteins in whey. While using a binary mixture of glycomacropeptide and betalactoglobulin, the selectivity was enhanced by over 600% as compared to an uncharged membrane. Using cheese whey, the increase in selectivity was about 220% for the charged versus uncharged membrane. The stagnant film model was found to fit the data well, and was a good predictor of the observed sieving coefficient versus flux.
590 $a School code: 0262.
650 4 $a Agriculture, Food Science and Technology. $3 1017813
690 $a 0359
710 2 $a The University of Wisconsin - Madison. $3 626640
773 0 $t Dissertation Abstracts International $g 69-09B.
790 $a 0262
790 1 0 $a Etzel, Mark R., $e advisor
791 $a Ph.D.
792 $a 2008
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3327973