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Spatial and curvature patterning of ...

University of California, Berkeley.

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Spatial and curvature patterning of biomembranes.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Spatial and curvature patterning of biomembranes./
作者:	Yu, Cheng-han.
面頁冊數:	83 p.
附註:	Adviser: Jay T. Groves.
Contained By:	Dissertation Abstracts International69-03B.
標題:	Biophysics, General. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3306398
ISBN:	9780549528128

Spatial and curvature patterning of biomembranes.
Yu, Cheng-han.

Spatial and curvature patterning of biomembranes. - 83 p.

Adviser: Jay T. Groves.

Thesis (Ph.D.)--University of California, Berkeley, 2007.

To study the heterogeneity of biomembranes, we have developed new techniques to spatially manipulate supported membranes by direct ultraviolet light patterning as well as by curvature modulations. In the study of cholesterol-dependent phase separation, we demonstrate that membrane deformation beyond a critical curvature value can spatially direct the ordering of phase-separated domains. We further utilize the patterning techniques in hybrid T cell immunological synapses, the live cell-supported membrane junction, and the driving force of membrane protein reorganizations in T cell is examined. T cell morphology and membrane protein distributions can be altered simply by imposing membrane deformations on T cell membranes. The ability to apply mechanical perturbation on cellular membranes enables us to investigate the mechanisms of membrane component transports and cytoskeletal regulations.

ISBN: 9780549528128Subjects--Topical Terms:

1019105
Biophysics, General.

Spatial and curvature patterning of biomembranes.
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300 $a 83 p.
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500 $a Source: Dissertation Abstracts International, Volume: 69-03, Section: B, page: 1675.
502 $a Thesis (Ph.D.)--University of California, Berkeley, 2007.
520 $a To study the heterogeneity of biomembranes, we have developed new techniques to spatially manipulate supported membranes by direct ultraviolet light patterning as well as by curvature modulations. In the study of cholesterol-dependent phase separation, we demonstrate that membrane deformation beyond a critical curvature value can spatially direct the ordering of phase-separated domains. We further utilize the patterning techniques in hybrid T cell immunological synapses, the live cell-supported membrane junction, and the driving force of membrane protein reorganizations in T cell is examined. T cell morphology and membrane protein distributions can be altered simply by imposing membrane deformations on T cell membranes. The ability to apply mechanical perturbation on cellular membranes enables us to investigate the mechanisms of membrane component transports and cytoskeletal regulations.
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