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The role of Hox genes in crustacean ...

University of California, Berkeley.

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The role of Hox genes in crustacean development and appendage specialization.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	The role of Hox genes in crustacean development and appendage specialization./
作者:	Liubicich, Danielle Marie.
面頁冊數:	245 p.
附註:	Adviser: Nipam H. Patel.
Contained By:	Dissertation Abstracts International69-03B.
標題:	Biology, Entomology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3306233
ISBN:	9780549531470

The role of Hox genes in crustacean development and appendage specialization.
Liubicich, Danielle Marie.

The role of Hox genes in crustacean development and appendage specialization. - 245 p.

Adviser: Nipam H. Patel.

Thesis (Ph.D.)--University of California, Berkeley, 2007.

Crustaceans are among the most morphologically diverse organisms existing today. Their body forms vary dramatically, and their appendages are often highly specialized to perform critical functions such as mating or defense. One particularly interesting specialized appendage is the maxilliped, a thoracic appendage that has been modified such that it appears more like a mouthpart and functions in feeding rather than locomotion like its thoracic counterparts. This thesis explores the possible genetic mechanisms by which the unique maxilliped morphology evolved. Previous experiments in crustaceans illustrated a correlation between the expression boundary of a particular patterning gene, Ultrabithorax (Ubx), and maxilliped specification in diverse crustaceans (Averof and Patel, 1007). Ubx is a member of a highly conserved family of genes, called Hox genes, which provide regional identity in animal body plans. Additional Hox genes are expressed in the maxilliped appendages of diverse crustaceans during development, including Sex combs reduced (Scr) and Antennapedia (Antp) and may also play an important role in specifying their unique identity (Abzhanov and Kaufman, 1999, 2000a,b).

ISBN: 9780549531470Subjects--Topical Terms:

1018619
Biology, Entomology.

The role of Hox genes in crustacean development and appendage specialization.
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245 1 4 $a The role of Hox genes in crustacean development and appendage specialization.
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502 $a Thesis (Ph.D.)--University of California, Berkeley, 2007.
520 $a Crustaceans are among the most morphologically diverse organisms existing today. Their body forms vary dramatically, and their appendages are often highly specialized to perform critical functions such as mating or defense. One particularly interesting specialized appendage is the maxilliped, a thoracic appendage that has been modified such that it appears more like a mouthpart and functions in feeding rather than locomotion like its thoracic counterparts. This thesis explores the possible genetic mechanisms by which the unique maxilliped morphology evolved. Previous experiments in crustaceans illustrated a correlation between the expression boundary of a particular patterning gene, Ultrabithorax (Ubx), and maxilliped specification in diverse crustaceans (Averof and Patel, 1007). Ubx is a member of a highly conserved family of genes, called Hox genes, which provide regional identity in animal body plans. Additional Hox genes are expressed in the maxilliped appendages of diverse crustaceans during development, including Sex combs reduced (Scr) and Antennapedia (Antp) and may also play an important role in specifying their unique identity (Abzhanov and Kaufman, 1999, 2000a,b).
520 $a To further our understanding of how changes in Hox gene expression may lead to crustacean appendage specialization, this project examined the role of Scr, Antp, and Ubx in maxilliped specification during Parhyale hawaiensis development. Parhyale hawaiensis is an amphipod crustacean raised in the lab that has become an incredibly useful system in which gene expression patterns, levels, and functions can be analyzed throughout development. Parhyale Hox expression analysis suggested that Scr, Antp and Ubx are all involved in Parhyale maxilliped specification, and the results of gene functional analysis confirmed PhUbx is critical for maxilliped identity. Reducing Parhyale Ubx function through injection of siRNAs resulted in transformation of some thoracic legs to a more maxilliped-like (mouthpart-like) identity. Misexpression of Parhyale Ubx through the use of a Minos transposable element system had the opposite effect, as head appendages and segments gained a more walking leg-like identity. Together, these experiments provide evidence that altering Hox gene expression was a potential mechanism by which the diversity of crustacean appendage morphology evolved.
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