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Expression evolution of mammalian genes.

University of Michigan.

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Expression evolution of mammalian genes.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Expression evolution of mammalian genes./
Author:	Liao, Ben-Yang.
Description:	169 p.
Notes:	Adviser: Jianzhi Zhang.
Contained By:	Dissertation Abstracts International69-09B.
Subject:	Biology, Bioinformatics. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3328891
ISBN:	9780549817932

Expression evolution of mammalian genes.
Liao, Ben-Yang.

Expression evolution of mammalian genes. - 169 p.

Adviser: Jianzhi Zhang.

Thesis (Ph.D.)--University of Michigan, 2008.

Comparing the expression-profiles of over 10,000 genes from the human and mouse genomes, I address fundamental questions on mammalian gene expression. First, I demonstrate that over 80% of human-mouse orthologous genes are evolutionarily conserved in their expression-profiles. This result highlights the importance of proper gene expression to fitness. Second, I show that highly expressed and tissue-specific genes tend to evolve slowly in expression-profile, implying that the expression pattern is of particular importance to highly expressed and tissue-specific genes. I then investigate the potential roles that gene expression plays in protein sequence evolution, dynamics of genome organization, and evolutionary changes of gene essentiality in mammals. My results indicate that tissue-specificity is a stronger determinant on protein evolutionary rate than gene expression level, a factor that is known to be the most important rate determinant in yeasts. The result suggests a great variation in rate determinants of protein sequence evolution between unicellular and multicellular organisms. Subsequently, my analyses on the origin of co-expressed gene clusters indicate that co-expression of linked genes is a form of transcriptional interference that is disadvantageous to organisms, suggesting that transcriptional interference may promote recurrent relocations of genes in the genome. Lastly, I study underlying mechanisms of the evolution of gene essentiality. The results show that the changes of gene essentiality appear to be associated with adaptive evolution at the protein-sequence level, while gene duplication and gene expression evolution plays a negligible role. Together, my studies help understand patterns, mechanisms and consequences of gene expression evolution.

ISBN: 9780549817932Subjects--Topical Terms:

1018415
Biology, Bioinformatics.

Expression evolution of mammalian genes.
LDR:02633nam 2200277 a 45 001 852718
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020 $a 9780549817932
035 $a (UMI)AAI3328891
035 $a AAI3328891
040 $a UMI $c UMI
100 1 $a Liao, Ben-Yang. $3 1018722
245 1 0 $a Expression evolution of mammalian genes.
300 $a 169 p.
500 $a Adviser: Jianzhi Zhang.
500 $a Source: Dissertation Abstracts International, Volume: 69-09, Section: B, page: 5133.
502 $a Thesis (Ph.D.)--University of Michigan, 2008.
520 $a Comparing the expression-profiles of over 10,000 genes from the human and mouse genomes, I address fundamental questions on mammalian gene expression. First, I demonstrate that over 80% of human-mouse orthologous genes are evolutionarily conserved in their expression-profiles. This result highlights the importance of proper gene expression to fitness. Second, I show that highly expressed and tissue-specific genes tend to evolve slowly in expression-profile, implying that the expression pattern is of particular importance to highly expressed and tissue-specific genes. I then investigate the potential roles that gene expression plays in protein sequence evolution, dynamics of genome organization, and evolutionary changes of gene essentiality in mammals. My results indicate that tissue-specificity is a stronger determinant on protein evolutionary rate than gene expression level, a factor that is known to be the most important rate determinant in yeasts. The result suggests a great variation in rate determinants of protein sequence evolution between unicellular and multicellular organisms. Subsequently, my analyses on the origin of co-expressed gene clusters indicate that co-expression of linked genes is a form of transcriptional interference that is disadvantageous to organisms, suggesting that transcriptional interference may promote recurrent relocations of genes in the genome. Lastly, I study underlying mechanisms of the evolution of gene essentiality. The results show that the changes of gene essentiality appear to be associated with adaptive evolution at the protein-sequence level, while gene duplication and gene expression evolution plays a negligible role. Together, my studies help understand patterns, mechanisms and consequences of gene expression evolution.
590 $a School code: 0127.
650 4 $a Biology, Bioinformatics. $3 1018415
650 4 $a Biology, Genetics. $3 1017730
690 $a 0369
690 $a 0715
710 2 $a University of Michigan. $3 777416
773 0 $t Dissertation Abstracts International $g 69-09B.
790 $a 0127
790 1 0 $a Zhang, Jianzhi, $e advisor
791 $a Ph.D.
792 $a 2008
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3328891