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The domestic dog mitochondrial genom...

The George Washington University., Biological Sciences.

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The domestic dog mitochondrial genome: Forensic and evolutionary evaluations.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	The domestic dog mitochondrial genome: Forensic and evolutionary evaluations./
作者:	Webb, Kristen Marie Gansberger.
面頁冊數:	212 p.
附註:	Adviser: Marc W. Allard.
Contained By:	Dissertation Abstracts International69-04B.
標題:	Biology, General. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3307718
ISBN:	9780549568223

The domestic dog mitochondrial genome: Forensic and evolutionary evaluations.
Webb, Kristen Marie Gansberger.

The domestic dog mitochondrial genome: Forensic and evolutionary evaluations. - 212 p.

Adviser: Marc W. Allard.

Thesis (Ph.D.)--The George Washington University, 2008.

Crime scenes often contain domestic dog (Canis lupus familiaris) hair. As hair can vary between and within individuals, DNA is often used as evidence. Little nuclear DNA is present in shed hair, but mitochondrial DNA is abundant. Here, 36 new haplotypes and 24 new single nucleotide polymorphisms (SNPs) are identified using mitochondrial control region (mtCR) sequences of 552 dogs from the United States. The probability of exclusion was 0.957. No genetic basis was found for distinguishing between purebred or mixed, or geographic location but grouping by breed did show significant genetic signal. The majority of the mtCR haplotypes were shared by between 11 and 59 individuals. The remainder of the mitochondrial genome (mtGenome) of 64 dogs from the mtCR study was sequenced and 15 complete dog mtGenomes downloaded from Genbank. Sixty-five haplotypes and 356 SNPs were identified using the remainder of the mtGenome. The probability of exclusion increased to 0.982. The results from the mtGenome study were consistent with those from the mtCR and provide additional resolution for the common mtCR haplotype groups.

ISBN: 9780549568223Subjects--Topical Terms:

1018625
Biology, General.

The domestic dog mitochondrial genome: Forensic and evolutionary evaluations.
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100 1 $a Webb, Kristen Marie Gansberger. $3 1018693
245 1 4 $a The domestic dog mitochondrial genome: Forensic and evolutionary evaluations.
300 $a 212 p.
500 $a Adviser: Marc W. Allard.
500 $a Source: Dissertation Abstracts International, Volume: 69-04, Section: B, page: 2027.
502 $a Thesis (Ph.D.)--The George Washington University, 2008.
520 $a Crime scenes often contain domestic dog (Canis lupus familiaris) hair. As hair can vary between and within individuals, DNA is often used as evidence. Little nuclear DNA is present in shed hair, but mitochondrial DNA is abundant. Here, 36 new haplotypes and 24 new single nucleotide polymorphisms (SNPs) are identified using mitochondrial control region (mtCR) sequences of 552 dogs from the United States. The probability of exclusion was 0.957. No genetic basis was found for distinguishing between purebred or mixed, or geographic location but grouping by breed did show significant genetic signal. The majority of the mtCR haplotypes were shared by between 11 and 59 individuals. The remainder of the mitochondrial genome (mtGenome) of 64 dogs from the mtCR study was sequenced and 15 complete dog mtGenomes downloaded from Genbank. Sixty-five haplotypes and 356 SNPs were identified using the remainder of the mtGenome. The probability of exclusion increased to 0.982. The results from the mtGenome study were consistent with those from the mtCR and provide additional resolution for the common mtCR haplotype groups.
520 $a Evolutionary evaluation of the mtCR showed that the distributions of haplotypes A, B, C, and D are consistent with worldwide surveys, although some rare haplotypes are missing from our dataset. Grouping dogs by American Kennel Club breed classifications and using parsimony methods shows that ancestors of working and sporting group dogs founded dog populations. We conclude that early human-canine interactions were based upon exploiting the canine's physical characteristics and cooperative hunting.
520 $a Evolutionary evaluation of the remainder of the mtGenome resulted in fewer phylogenetic reconstructions, better resolution of within haplogroup relationships and higher support scores when compared to the mtCR. Individual analyses of each of the 13 protein coding genes and 2 rRNAs showed that these regions alone do not produce as robust resolutions as the mtGenome. We estimate a domestication date of 50,000 years ago +/- 1,557 years. Compared to the widely accepted date of 15,000 years ago, which seems to be favored due to close agreement with the fossil record, we propose that domestication began tens of thousands of years before the first morphological dog appeared.
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790 1 0 $a Hormiga, Gustavo $e committee member
790 1 0 $a Johnson, Diana E. $e committee member
790 1 0 $a Wilson, Mark $e committee member
791 $a Ph.D.
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