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Interleukin 10 (IL-10) selectively i...
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Florida Atlantic University.
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Interleukin 10 (IL-10) selectively inhibits neovascularization in the murine model of retinopathy of prematurity.
紀錄類型:
書目-語言資料,印刷品 : Monograph/item
正題名/作者:
Interleukin 10 (IL-10) selectively inhibits neovascularization in the murine model of retinopathy of prematurity./
作者:
Solomon, Evertz Stenson.
面頁冊數:
35 p.
附註:
Adviser: Janet Blanks.
Contained By:
Masters Abstracts International45-05.
標題:
Biology, Neuroscience. -
電子資源:
http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1441990
Interleukin 10 (IL-10) selectively inhibits neovascularization in the murine model of retinopathy of prematurity.
Solomon, Evertz Stenson.
Interleukin 10 (IL-10) selectively inhibits neovascularization in the murine model of retinopathy of prematurity.
- 35 p.
Adviser: Janet Blanks.
Thesis (M.S.)--Florida Atlantic University, 2007.
Ocular neovascularization (NV), the development of new blood vessels in the eye, occurs when excessive vascular endothelial growth factor (VEGF) is produced. Eventually NV may lead to photoreceptor loss and or blindness, as it does in age-related macular degeneration (AMD), retinopathy of prematurity (ROP), and diabetic retinopathy.Subjects--Topical Terms:
1017680
Biology, Neuroscience.
Interleukin 10 (IL-10) selectively inhibits neovascularization in the murine model of retinopathy of prematurity.
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Ocular neovascularization (NV), the development of new blood vessels in the eye, occurs when excessive vascular endothelial growth factor (VEGF) is produced. Eventually NV may lead to photoreceptor loss and or blindness, as it does in age-related macular degeneration (AMD), retinopathy of prematurity (ROP), and diabetic retinopathy.
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We tested the hypothesis that the anti-inflammatory cytokine, interleukin-10 (IL-10); can reduce inflammation and block NV in the affected areas of the retina. The mouse ROP model was used for this study of NV. Seven day old neonates stayed in 75% oxygen for five days, then were given intraocular injection of IL-10 and NV was evaluated after seven days in room air. Controls were uninjected contralateral eyes. IL-10 strongly inhibited NV without affecting intra-retinal vessels. The selective inhibition of IL-10 on NV suggest a possible therapeutic use in infants with ROP, in diabetic retinopathy, and possibly, in AMD where inflammation is a risk factor.
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http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1441990
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