語系:
繁體中文
English
說明(常見問題)
回圖書館首頁
手機版館藏查詢
登入
回首頁
切換:
標籤
|
MARC模式
|
ISBD
Regulation of interferon alphabeta i...
~
Case Western Reserve University.
FindBook
Google Book
Amazon
博客來
Regulation of interferon alphabeta induction and dendritic cell function by CpG oligodeoxynucleotides.
紀錄類型:
書目-語言資料,印刷品 : Monograph/item
正題名/作者:
Regulation of interferon alphabeta induction and dendritic cell function by CpG oligodeoxynucleotides./
作者:
Gray, Reginald Courtney.
面頁冊數:
181 p.
附註:
Adviser: Clifford V. Harding.
Contained By:
Dissertation Abstracts International68-08B.
標題:
Health Sciences, Immunology. -
電子資源:
http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3276739
ISBN:
9780549180012
Regulation of interferon alphabeta induction and dendritic cell function by CpG oligodeoxynucleotides.
Gray, Reginald Courtney.
Regulation of interferon alphabeta induction and dendritic cell function by CpG oligodeoxynucleotides.
- 181 p.
Adviser: Clifford V. Harding.
Thesis (Ph.D.)--Case Western Reserve University, 2008.
Deoxycytidyl-deoxyguanosine (CpG) oligodeoxynucleotides (ODNs) are single strands of synthetic DNA that mimic bacterial and viral DNA. CpG ODNs are divided into three classes (CpG-A, -B, and -C), which differ in their sequence characteristics and immunomodulatory functions. All three classes signal through TLR9. TLRs and other pattern recognition receptors are under intense therapeutic targeting in attempts to modulate innate and adaptive immune responses with the purpose of treating human immunological disorders. CpG DNA has progressed from successful animal studies to clinical studies in the areas of vaccine adjuvants and therapies for infectious diseases, allergies, asthma, and cancer. The focus of this dissertation is to better understand how CpG ODNs modulate immune function on antigen presenting cells (APCs), particularly murine dendritic cells (DCs). The initial studies examine cross-presentation of particulate Ag by DCs in the presence of CpG ODNs. Cross-presentation plays a major role in driving an adaptive immune response following a pathogenic challenge and gives APCs the ability to activate an adaptive immune response in the absence of self-infection. CpG-B ODNs are not as efficacious as CpG-A and -C ODNs at inducing type-I IFN; however, they are as effective as the other two classes at stimulating MHC-I Ag cross-presentation, a type-I IFN dependent process. These studies also demonstrate that high concentrations of CpG-B selectively inhibit production of type-I IFN induced by other Toll-like receptor (TLR)-9 agonists, as well as other MyD88-dependent and -independent TLR agonists and a non-TLR agonist. The final studies explore the mechanism(s) involved in CpG-B-induced inhibition of type-I IFN and conclude with the possibility that CpG-B, at high (inhibitory) concentrations, may signal via a novel non-TLR9 pathway. Collectively, these studies contribute to a better understanding of how CpG ODNs, particularly CpG-B, modulate DC function in the murine system, offering an additional approach to designing ODN therapies for human use.
ISBN: 9780549180012Subjects--Topical Terms:
1017716
Health Sciences, Immunology.
Regulation of interferon alphabeta induction and dendritic cell function by CpG oligodeoxynucleotides.
LDR
:03002nam 2200277 a 45
001
852048
005
20100629
008
100629s2008 ||||||||||||||||| ||eng d
020
$a
9780549180012
035
$a
(UMI)AAI3276739
035
$a
AAI3276739
040
$a
UMI
$c
UMI
100
1
$a
Gray, Reginald Courtney.
$3
1017715
245
1 0
$a
Regulation of interferon alphabeta induction and dendritic cell function by CpG oligodeoxynucleotides.
300
$a
181 p.
500
$a
Adviser: Clifford V. Harding.
500
$a
Source: Dissertation Abstracts International, Volume: 68-08, Section: B, page: 5158.
502
$a
Thesis (Ph.D.)--Case Western Reserve University, 2008.
520
$a
Deoxycytidyl-deoxyguanosine (CpG) oligodeoxynucleotides (ODNs) are single strands of synthetic DNA that mimic bacterial and viral DNA. CpG ODNs are divided into three classes (CpG-A, -B, and -C), which differ in their sequence characteristics and immunomodulatory functions. All three classes signal through TLR9. TLRs and other pattern recognition receptors are under intense therapeutic targeting in attempts to modulate innate and adaptive immune responses with the purpose of treating human immunological disorders. CpG DNA has progressed from successful animal studies to clinical studies in the areas of vaccine adjuvants and therapies for infectious diseases, allergies, asthma, and cancer. The focus of this dissertation is to better understand how CpG ODNs modulate immune function on antigen presenting cells (APCs), particularly murine dendritic cells (DCs). The initial studies examine cross-presentation of particulate Ag by DCs in the presence of CpG ODNs. Cross-presentation plays a major role in driving an adaptive immune response following a pathogenic challenge and gives APCs the ability to activate an adaptive immune response in the absence of self-infection. CpG-B ODNs are not as efficacious as CpG-A and -C ODNs at inducing type-I IFN; however, they are as effective as the other two classes at stimulating MHC-I Ag cross-presentation, a type-I IFN dependent process. These studies also demonstrate that high concentrations of CpG-B selectively inhibit production of type-I IFN induced by other Toll-like receptor (TLR)-9 agonists, as well as other MyD88-dependent and -independent TLR agonists and a non-TLR agonist. The final studies explore the mechanism(s) involved in CpG-B-induced inhibition of type-I IFN and conclude with the possibility that CpG-B, at high (inhibitory) concentrations, may signal via a novel non-TLR9 pathway. Collectively, these studies contribute to a better understanding of how CpG ODNs, particularly CpG-B, modulate DC function in the murine system, offering an additional approach to designing ODN therapies for human use.
590
$a
School code: 0042.
650
4
$a
Health Sciences, Immunology.
$3
1017716
650
4
$a
Health Sciences, Pharmacology.
$3
1017717
690
$a
0419
690
$a
0982
710
2
$a
Case Western Reserve University.
$3
1017714
773
0
$t
Dissertation Abstracts International
$g
68-08B.
790
$a
0042
790
1 0
$a
Harding, Clifford V.,
$e
advisor
791
$a
Ph.D.
792
$a
2008
856
4 0
$u
http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3276739
筆 0 讀者評論
館藏地:
全部
電子資源
出版年:
卷號:
館藏
1 筆 • 頁數 1 •
1
條碼號
典藏地名稱
館藏流通類別
資料類型
索書號
使用類型
借閱狀態
預約狀態
備註欄
附件
W9068916
電子資源
11.線上閱覽_V
電子書
EB W9068916
一般使用(Normal)
在架
0
1 筆 • 頁數 1 •
1
多媒體
評論
新增評論
分享你的心得
Export
取書館
處理中
...
變更密碼
登入