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The Genetic, Molecular, and Neuroend...

Niepoth, Natalie,

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The Genetic, Molecular, and Neuroendocrine Basis of Behavioral Evolution in Deer Mice /

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	The Genetic, Molecular, and Neuroendocrine Basis of Behavioral Evolution in Deer Mice // Natalie Niepoth.
作者:	Niepoth, Natalie,
面頁冊數:	1 electronic resource (162 pages)
附註:	Source: Dissertations Abstracts International, Volume: 85-07, Section: B.
Contained By:	Dissertations Abstracts International85-07B.
標題:	Genetics. -
電子資源:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30818789
ISBN:	9798381381108

The Genetic, Molecular, and Neuroendocrine Basis of Behavioral Evolution in Deer Mice /
Niepoth, Natalie,

The Genetic, Molecular, and Neuroendocrine Basis of Behavioral Evolution in Deer Mice /Natalie Niepoth. - 1 electronic resource (162 pages)

Source: Dissertations Abstracts International, Volume: 85-07, Section: B.

Despite the extraordinary diversity of behavior across the animal kingdom, the genes and molecules that contribute to such natural diversity are largely unknown. In this thesis, I leverage the dramatic divergence in behavior between two closely related species of deer mice (genus Peromyscus) to investigate the genetic, cellular, and neuroendocrine basis of behavior. In chapter 2, I show that the monogamous oldfield mouse (Peromyscus polionotus subgriseus) has evolved a novel cell type in the adrenal gland that expresses the enzyme AKR1C18, which converts progesterone into 20α-hydroxyprogesterone (20α-OHP). I then demonstrate that 20α-OHP is more abundant in oldfield mice than in the closely-related promiscuous prairie deer mouse (P. maniculatus bairdii) and that it increases monogamous-typical parental behaviors when administered to both monogamous fathers. Using quantitative trait locus mapping in a cross between these species, I discover interspecific genetic variation that drives expression of the glycoprotein tenascin N and ultimately contributes to gain of adrenal AKR1C18 expression in oldfield mice. In chapter 3, I investigate the genetic architecture underlying the striking difference in exploratory behavior between prairie deer mice and oldfield mice. Through congenic fine-mapping, I identify a 15-Mb locus that strongly contributes to species differences in exploratory behavior. I then investigate the potential contributions of one of the 18 genes in the locus, Olfm4, which harbors cis-regulatory variants that drives its expression in the oldfield hypothalamus. Taken together, my research advances our understanding of the genetic and molecular causes that drive rapid behavioral divergence between species.

English

ISBN: 9798381381108Subjects--Topical Terms:

530508
Genetics.
Subjects--Index Terms:

Animal kingdom

The Genetic, Molecular, and Neuroendocrine Basis of Behavioral Evolution in Deer Mice /
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