東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

Statistical Machine Learning Methodo...

Shah, Kushal S.

FindBook

Google Book

Amazon

博客來

Statistical Machine Learning Methodology for Individualized Treatment Rule Estimation in Precision Medicine.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Statistical Machine Learning Methodology for Individualized Treatment Rule Estimation in Precision Medicine./
作者:	Shah, Kushal S.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2023,
面頁冊數:	124 p.
附註:	Source: Dissertations Abstracts International, Volume: 85-02, Section: B.
Contained By:	Dissertations Abstracts International85-02B.
標題:	Biostatistics. -
電子資源:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30571713
ISBN:	9798380134163

Statistical Machine Learning Methodology for Individualized Treatment Rule Estimation in Precision Medicine.
Shah, Kushal S.

Statistical Machine Learning Methodology for Individualized Treatment Rule Estimation in Precision Medicine. - Ann Arbor : ProQuest Dissertations & Theses, 2023 - 124 p.

Source: Dissertations Abstracts International, Volume: 85-02, Section: B.

Thesis (Ph.D.)--The University of North Carolina at Chapel Hill, 2023.

Precision medicine aims to deliver optimal, individualized treatments for patients by accounting for their unique characteristics. With a foundation in reinforcement learning, decision theory, and causal inference, the field of precision medicine has seen many advancements in recent years. Significant focus has been placed on creating algorithms to estimate individualized treatment rules (ITRs), which map from patient covariates to the space of available treatments with the goal of maximizing patient outcome. In Chapter 1, we extend ITR estimation methodology in the scenario where variance of the outcome is heterogeneous with respect to treatment and covariates. Accordingly, we propose Stabilized Direct Learning (SD-Learning), which utilizes heteroscedasticity in the error term through a residual reweighting framework that models residual variance via flexible machine learning algorithms such as XGBoost and random forests. We also develop an internal cross-validation scheme which determines the best residual model among competing models. Further, we extend this methodology to multi-arm treatment scenarios. In Chapter 2, we develop ITR estimation methodology for situations where clinical decision-making involves balancing multiple outcomes of interest. Our proposed framework estimates an ITR which maximizes a combination of the multiple clinical outcomes, accounting for the fact that patients may ascribe importance to outcomes differently (utility heterogeneity). This approach employs inverse reinforcement learning (IRL) techniques through an expert-augmentation solution, whereby physicians provide input to guide the utility estimation and ITR learning processes.In Chapter 3, we apply an end-to-end precision medicine workflow to novel data from older adults with Type 1 Diabetes in order to understand the heterogeneous treatment effects of continuous glucose monitoring (CGM) and develop an interpretable ITR to reveal patients for which CGM confers a major safety benefit. The results from this analysis elucidate the demographic and clinical markers which moderate CGM's success, provide the basis for using diagnostic CGM to inform therapeutic CGM decisions, and serve to augment clinical decision-making. Finally, in Chapter 4, as a future research direction, we propose a deep autoencoder framework which simultaneously performs feature selection and ITR optimization, contributing to methodology built for direct consumption of unstructured, high-dimensional data in the precision medicine pipeline.

ISBN: 9798380134163Subjects--Topical Terms:

1002712
Biostatistics.
Subjects--Index Terms:

Decision theory

Statistical Machine Learning Methodology for Individualized Treatment Rule Estimation in Precision Medicine.
LDR:03776nmm a2200385 4500 001 2398522
005 20240812064658.5
006 m o d
007 cr#unu||||||||
008 251215s2023 ||||||||||||||||| ||eng d
020 $a 9798380134163
035 $a (MiAaPQ)AAI30571713
035 $a AAI30571713
040 $a MiAaPQ $c MiAaPQ
100 1 $a Shah, Kushal S. $3 3768436
245 1 0 $a Statistical Machine Learning Methodology for Individualized Treatment Rule Estimation in Precision Medicine.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2023
300 $a 124 p.
500 $a Source: Dissertations Abstracts International, Volume: 85-02, Section: B.
500 $a Advisor: Kosorok, Michael R.;Fu, Haoda.
502 $a Thesis (Ph.D.)--The University of North Carolina at Chapel Hill, 2023.
520 $a Precision medicine aims to deliver optimal, individualized treatments for patients by accounting for their unique characteristics. With a foundation in reinforcement learning, decision theory, and causal inference, the field of precision medicine has seen many advancements in recent years. Significant focus has been placed on creating algorithms to estimate individualized treatment rules (ITRs), which map from patient covariates to the space of available treatments with the goal of maximizing patient outcome. In Chapter 1, we extend ITR estimation methodology in the scenario where variance of the outcome is heterogeneous with respect to treatment and covariates. Accordingly, we propose Stabilized Direct Learning (SD-Learning), which utilizes heteroscedasticity in the error term through a residual reweighting framework that models residual variance via flexible machine learning algorithms such as XGBoost and random forests. We also develop an internal cross-validation scheme which determines the best residual model among competing models. Further, we extend this methodology to multi-arm treatment scenarios. In Chapter 2, we develop ITR estimation methodology for situations where clinical decision-making involves balancing multiple outcomes of interest. Our proposed framework estimates an ITR which maximizes a combination of the multiple clinical outcomes, accounting for the fact that patients may ascribe importance to outcomes differently (utility heterogeneity). This approach employs inverse reinforcement learning (IRL) techniques through an expert-augmentation solution, whereby physicians provide input to guide the utility estimation and ITR learning processes.In Chapter 3, we apply an end-to-end precision medicine workflow to novel data from older adults with Type 1 Diabetes in order to understand the heterogeneous treatment effects of continuous glucose monitoring (CGM) and develop an interpretable ITR to reveal patients for which CGM confers a major safety benefit. The results from this analysis elucidate the demographic and clinical markers which moderate CGM's success, provide the basis for using diagnostic CGM to inform therapeutic CGM decisions, and serve to augment clinical decision-making. Finally, in Chapter 4, as a future research direction, we propose a deep autoencoder framework which simultaneously performs feature selection and ITR optimization, contributing to methodology built for direct consumption of unstructured, high-dimensional data in the precision medicine pipeline.
590 $a School code: 0153.
650 4 $a Biostatistics. $3 1002712
650 4 $a Statistics. $3 517247
653 $a Decision theory
653 $a Precision health
653 $a Precision medicine
653 $a Reinforcement learning
653 $a Statistical machine learning
690 $a 0308
690 $a 0463
690 $a 0800
710 2 $a The University of North Carolina at Chapel Hill. $b Biostatistics. $3 1023527
773 0 $t Dissertations Abstracts International $g 85-02B.
790 $a 0153
791 $a Ph.D.
792 $a 2023
793 $a English
856 4 0 $u https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30571713