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Systemic Tumor Immunity Across Tumor Development and Metastatic Progression.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Systemic Tumor Immunity Across Tumor Development and Metastatic Progression./
作者:	Martins, Maria Margarida.
面頁冊數:	1 online resource (133 pages)
附註:	Source: Dissertations Abstracts International, Volume: 84-11, Section: A.
Contained By:	Dissertations Abstracts International84-11A.
標題:	Vaccines. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30411568click for full text (PQDT)
ISBN:	9798379473686

Systemic Tumor Immunity Across Tumor Development and Metastatic Progression.
Martins, Maria Margarida.

Systemic Tumor Immunity Across Tumor Development and Metastatic Progression. - 1 online resource (133 pages)

Source: Dissertations Abstracts International, Volume: 84-11, Section: A.

Thesis (Ph.D.)--Stanford University, 2022.

Includes bibliographical references

The study of tumor immunology has led to great successes in the advancement of effective cancer treatments. Despite these advances, there are still tumor types and patient populations that remain unresponsive to current immunotherapies. My studies are intended to better understand the mechanisms and consequences of tumor-immune cell interactions. The studies in Chapter 1 demonstrate that effective immune responses maintain activation and proliferation of lymphocytes in the periphery rather than the tumor microenvironment. This work provides insight into the mechanisms of effective immunotherapy responses in solid tumors while also demonstrating the importance of taking a system-wide approach to such studies. We then use a mouse model of lymph node metastasis developed in our lab to investigate the factors that enable primary tumor cells to survive immune attack as they traffic to the draining lymph nodes. Based on this work we introduce our "Metastatic Tolerance" model which describes that lymph node colonization induces systemic tumor-immune tolerance and thus enables distant metastasis. In chapter two I expand on our model of metastatic tolerance by identifying B cells as an important cell type in both melanoma lymph node metastasis and tolerance induction. In chapter three I once again take a system-wide approach to demonstrate how specific genotypes, specifically Kras mutation and Trp53 deletion, alter immune responses in pancreatitis prior to the development of pancreatic ductile adenocarcinoma.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2023

Mode of access: World Wide Web

ISBN: 9798379473686Subjects--Topical Terms:

684854
Vaccines.
Index Terms--Genre/Form:

542853
Electronic books.

Systemic Tumor Immunity Across Tumor Development and Metastatic Progression.
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