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The Association of Platelet Count on Cancer Incidence and Survival.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	The Association of Platelet Count on Cancer Incidence and Survival./
作者:	Giannakeas, Vasily.
面頁冊數:	1 online resource (279 pages)
附註:	Source: Dissertations Abstracts International, Volume: 84-05, Section: B.
Contained By:	Dissertations Abstracts International84-05B.
標題:	Epidemiology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=29392181click for full text (PQDT)
ISBN:	9798357547620

The Association of Platelet Count on Cancer Incidence and Survival.
Giannakeas, Vasily.

The Association of Platelet Count on Cancer Incidence and Survival. - 1 online resource (279 pages)

Source: Dissertations Abstracts International, Volume: 84-05, Section: B.

Thesis (Ph.D.)--University of Toronto (Canada), 2022.

Includes bibliographical references

Platelets are cellular fragments in the blood that have a primary purpose of forming blood clots during a blood vessel injury. Platelets have been shown to play an important role in cancer development and progression. Activated platelets promote tumour growth and angiogenesis in the early stages of tumour development, and mediate tumour cell dissemination and metastasis. It remains unclear to what extent platelet count is influenced by the presence of cancer and with which types of cancer.This dissertation is composed of four studies. In the first study I investigate the association between platelet count and a new diagnosis of cancer. Individuals with a high platelet count were more likely to be diagnosed with cancer. The association was most pronounced for gastrointestinal cancers (colon, stomach, esophageal), lung cancer, kidney cancer, and ovarian cancer.In the second study I aimed to determine if there is an elevated risk of cancer among individuals with a high platelet count (i.e. thrombocytosis). Among individuals with newly developed thrombocytosis there was an elevated risk of cancer of the colon, lung, ovary, stomach, kidney, and esophagus. Individuals with thrombocytosis may benefit from subsequent cancer screening.The third study looked at platelet count as a marker of cancer survival among cancer patients. Platelet count was associated with cancer survival for several types of cancer. The findings suggest that platelet count could potentially be used as a risk stratification measure for cancer patients.The fourth study was a descriptive analysis on trends in platelet count in a cohort of cancer patients. Platelet count increased in the months preceding a cancer diagnosis. After diagnosis, platelet count was elevated among patients that died from the cancer.This dissertation work highlights a profound relationship between platelet count and cancer outcomes. Clinical implications of this work include screening for cancer among patients with newly developed thrombocytosis, risk stratify cancer patients according to platelet count, and monitor patients for an increase in platelet count after diagnosis. I hope these findings will advance the literature and provide motivation to pursue clinical research on platelet mechanisms and cancer outcomes.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2023

Mode of access: World Wide Web

ISBN: 9798357547620Subjects--Topical Terms:

568544
Epidemiology.
Subjects--Index Terms:

CancerIndex Terms--Genre/Form:

542853
Electronic books.

The Association of Platelet Count on Cancer Incidence and Survival.
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