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Assessment of Sex Differences Following Repeated Mild Head Injury.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Assessment of Sex Differences Following Repeated Mild Head Injury./
作者:	Duggal, Aakaash.
面頁冊數:	1 online resource (63 pages)
附註:	Source: Masters Abstracts International, Volume: 84-01.
Contained By:	Masters Abstracts International84-01.
標題:	Neurosciences. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=29169624click for full text (PQDT)
ISBN:	9798834038429

Assessment of Sex Differences Following Repeated Mild Head Injury.
Duggal, Aakaash.

Assessment of Sex Differences Following Repeated Mild Head Injury. - 1 online resource (63 pages)

Source: Masters Abstracts International, Volume: 84-01.

Thesis (M.S.)--University of North Texas Health Science Center at Fort Worth, 2022.

Includes bibliographical references

There is limited information about sex differences in mRHI, despite some studies suggesting females participating in contact sports experience more head injuries than males. This study will test the hypothesis that mRHI will lead to more severe neurological deficits in female mice than in male mice. C57BL/6 female mice were assigned to sham and mRHI groups (n=30/group). Lightly anesthetized mice received 25 mild head injuries, once a day (M-F) over 5 weeks using a weight drop model that included a free fall with rotational injury. Acutely, mRHI female mice performed worse than sham injured mice on the balance beam (F (1,28) =4.309, P=0.0472) whereas there was no difference in males. 5 weeks and 15 weeks after injury mice underwent a 3-week series of behavioral tests. Both male and female mice in the mRHI groups performed significantly (T-test P< 0.01) worse on the Rotarod than uninjured controls. Only males in MWM showed significant impairment on memory for 5-week and significant impairment on spatial learning and memory for 15-week (Probe T-test P< 0.05). Only 15-week male mice showed deficits in elevated plus maze (EPM) (T-test P< 0.05). Acutely, female mice showed balance deficits that were not apparent in males. Fifteen weeks after mRHI, males no longer displayed deficits in the rotarod, but female mice continued to have a decrease in performance compared to controls (T-test, P<0.05). Unlike the males, female mice did not display any significant deficits in the MWM and EPM.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2023

Mode of access: World Wide Web

ISBN: 9798834038429Subjects--Topical Terms:

588700
Neurosciences.
Subjects--Index Terms:

Head injuriesIndex Terms--Genre/Form:

542853
Electronic books.

Assessment of Sex Differences Following Repeated Mild Head Injury.
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504 $a Includes bibliographical references
520 $a There is limited information about sex differences in mRHI, despite some studies suggesting females participating in contact sports experience more head injuries than males. This study will test the hypothesis that mRHI will lead to more severe neurological deficits in female mice than in male mice. C57BL/6 female mice were assigned to sham and mRHI groups (n=30/group). Lightly anesthetized mice received 25 mild head injuries, once a day (M-F) over 5 weeks using a weight drop model that included a free fall with rotational injury. Acutely, mRHI female mice performed worse than sham injured mice on the balance beam (F (1,28) =4.309, P=0.0472) whereas there was no difference in males. 5 weeks and 15 weeks after injury mice underwent a 3-week series of behavioral tests. Both male and female mice in the mRHI groups performed significantly (T-test P< 0.01) worse on the Rotarod than uninjured controls. Only males in MWM showed significant impairment on memory for 5-week and significant impairment on spatial learning and memory for 15-week (Probe T-test P< 0.05). Only 15-week male mice showed deficits in elevated plus maze (EPM) (T-test P< 0.05). Acutely, female mice showed balance deficits that were not apparent in males. Fifteen weeks after mRHI, males no longer displayed deficits in the rotarod, but female mice continued to have a decrease in performance compared to controls (T-test, P<0.05). Unlike the males, female mice did not display any significant deficits in the MWM and EPM.
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538 $a Mode of access: World Wide Web
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650 4 $a Behavioral sciences. $3 529833
653 $a Head injuries
653 $a Mild repeated head injury
653 $a Repeated mild traumatic brain injury
653 $a Sex differences in head injuries
653 $a Sex differences in repeated mild head injuries
653 $a Traumatic brain injury
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