東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

FindBook

Google Book

Amazon

博客來

Development of a Mini-Pig Model of Radiation-Induced Brain Injury.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Development of a Mini-Pig Model of Radiation-Induced Brain Injury./
作者:	Perez, Whitney Diep.
面頁冊數:	1 online resource (162 pages)
附註:	Source: Dissertations Abstracts International, Volume: 85-01, Section: A.
Contained By:	Dissertations Abstracts International85-01A.
標題:	Brain cancer. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30506221click for full text (PQDT)
ISBN:	9798379848149

Development of a Mini-Pig Model of Radiation-Induced Brain Injury.
Perez, Whitney Diep.

Development of a Mini-Pig Model of Radiation-Induced Brain Injury. - 1 online resource (162 pages)

Source: Dissertations Abstracts International, Volume: 85-01, Section: A.

Thesis (Ph.D.)--Purdue University, 2022.

Includes bibliographical references

While radiation therapy is a standard treatment modality for managing primary and metastatic brain tumors, it causes irreversible and progressive long-term side effects that decrease the quality of life for pediatric brain tumor survivors. These side effects, known as radiationinduced brain injury (RIBI) and which occur at least 6 months post-treatment, create challenges in education, employment, and social relationships throughout the patients' lifetime. With the prognosis for pediatric cancer patients constantly improving, long-term side effects such as RIBI pose a major clinical problem for post-treatment care. To create and evaluate treatments for this clinical injury, it is critical to understand how this condition forms and develops. However, this cannot be done in patients due to the invasive nature of cranial biopsies. The current scientific understanding behind the pathophysiology of these late-delayed forms of RIBI is therefore built upon studies of pre-clinical animal models. Such experimental models, typically of healthy rodents, are not currently capable of accurately replicating the radiological and histological changes seen in human patients. This inconsistency limits the efficacy of preclinical discoveries when translated to clinical trials. To address this issue, we chose to establish a mini-pig model for RIBI using a standard clinical approach of radiation delivery and follow-up imaging. Our hypothesis is that cranial irradiation of the mini-pig brain will elucidate the clinical magnetic resonance imaging (MRI) signatures of RIBI, which will then correspond to characteristic changes in diffusion properties, metabolite profiles, immune constituents, and glial and neuronal cell subpopulations as evidenced by advanced MRI techniques and histopathology. As such, results from Aim 1 have highlighted not only incongruencies between rodent models and clinical findings, but also various inconsistencies in current assessment techniques of late-delayed RIBI in patients. Additionally, results from Aim 2 have established the feasibility of a mini-pig model of RIBI based on the current clinical standard of diagnosis. Finally, results from Aim 3 describe characteristic changes in diffusion properties and histological appearances as well as novel changes in metabolite concentrations within our mini-pig model late-delayed RIBI. In conclusion, this intermediate animal model of RIBI can replicate the clinical condition and may ultimately provide valuable insight into the pathophysiology of RIBI.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2023

Mode of access: World Wide Web

ISBN: 9798379848149Subjects--Topical Terms:

3557728
Brain cancer.
Index Terms--Genre/Form:

542853
Electronic books.

Development of a Mini-Pig Model of Radiation-Induced Brain Injury.
LDR:03897nmm a2200421K 4500 001 2363540
005 20231127093435.5
006 m o d
007 cr mn ---uuuuu
008 241011s2022 xx obm 000 0 eng d
020 $a 9798379848149
035 $a (MiAaPQ)AAI30506221
035 $a (MiAaPQ)Purdue19650435
035 $a AAI30506221
040 $a MiAaPQ $b eng $c MiAaPQ $d NTU
100 1 $a Perez, Whitney Diep. $3 3704308
245 1 0 $a Development of a Mini-Pig Model of Radiation-Induced Brain Injury.
264 0 $c 2022
300 $a 1 online resource (162 pages)
336 $a text $b txt $2 rdacontent
337 $a computer $b c $2 rdamedia
338 $a online resource $b cr $2 rdacarrier
500 $a Source: Dissertations Abstracts International, Volume: 85-01, Section: A.
500 $a Advisor: Dydak, Ulrike.
502 $a Thesis (Ph.D.)--Purdue University, 2022.
504 $a Includes bibliographical references
520 $a While radiation therapy is a standard treatment modality for managing primary and metastatic brain tumors, it causes irreversible and progressive long-term side effects that decrease the quality of life for pediatric brain tumor survivors. These side effects, known as radiationinduced brain injury (RIBI) and which occur at least 6 months post-treatment, create challenges in education, employment, and social relationships throughout the patients' lifetime. With the prognosis for pediatric cancer patients constantly improving, long-term side effects such as RIBI pose a major clinical problem for post-treatment care. To create and evaluate treatments for this clinical injury, it is critical to understand how this condition forms and develops. However, this cannot be done in patients due to the invasive nature of cranial biopsies. The current scientific understanding behind the pathophysiology of these late-delayed forms of RIBI is therefore built upon studies of pre-clinical animal models. Such experimental models, typically of healthy rodents, are not currently capable of accurately replicating the radiological and histological changes seen in human patients. This inconsistency limits the efficacy of preclinical discoveries when translated to clinical trials. To address this issue, we chose to establish a mini-pig model for RIBI using a standard clinical approach of radiation delivery and follow-up imaging. Our hypothesis is that cranial irradiation of the mini-pig brain will elucidate the clinical magnetic resonance imaging (MRI) signatures of RIBI, which will then correspond to characteristic changes in diffusion properties, metabolite profiles, immune constituents, and glial and neuronal cell subpopulations as evidenced by advanced MRI techniques and histopathology. As such, results from Aim 1 have highlighted not only incongruencies between rodent models and clinical findings, but also various inconsistencies in current assessment techniques of late-delayed RIBI in patients. Additionally, results from Aim 2 have established the feasibility of a mini-pig model of RIBI based on the current clinical standard of diagnosis. Finally, results from Aim 3 describe characteristic changes in diffusion properties and histological appearances as well as novel changes in metabolite concentrations within our mini-pig model late-delayed RIBI. In conclusion, this intermediate animal model of RIBI can replicate the clinical condition and may ultimately provide valuable insight into the pathophysiology of RIBI.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2023
538 $a Mode of access: World Wide Web
650 4 $a Brain cancer. $3 3557728
650 4 $a Spectrum analysis. $3 520440
650 4 $a Cancer therapies. $3 3557730
650 4 $a Radiation therapy. $3 3557731
650 4 $a Metabolites. $3 683644
650 4 $a Magnetic resonance imaging. $3 554355
650 4 $a Analytical chemistry. $3 3168300
650 4 $a Chemistry. $3 516420
650 4 $a Medical imaging. $3 3172799
650 4 $a Nuclear physics. $3 517741
650 4 $a Oncology. $3 751006
650 4 $a Optics. $3 517925
650 4 $a Pharmaceutical sciences. $3 3173021
650 4 $a Physics. $3 516296
650 4 $a Therapy. $3 3343697
655 7 $a Electronic books. $2 lcsh $3 542853
690 $a 0486
690 $a 0485
690 $a 0574
690 $a 0756
690 $a 0992
690 $a 0752
690 $a 0572
690 $a 0605
690 $a 0212
710 2 $a ProQuest Information and Learning Co. $3 783688
710 2 $a Purdue University. $3 1017663
773 0 $t Dissertations Abstracts International $g 85-01A.
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30506221 $z click for full text (PQDT)