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Skin Type-Dependent Development of Specialized Mechanosensory Neurons.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Skin Type-Dependent Development of Specialized Mechanosensory Neurons./
作者:	Koutsioumpa, Charalampia.
面頁冊數:	1 online resource (129 pages)
附註:	Source: Dissertations Abstracts International, Volume: 84-12, Section: B.
Contained By:	Dissertations Abstracts International84-12B.
標題:	Neurosciences. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30491558click for full text (PQDT)
ISBN:	9798379612962

Skin Type-Dependent Development of Specialized Mechanosensory Neurons.
Koutsioumpa, Charalampia.

Skin Type-Dependent Development of Specialized Mechanosensory Neurons. - 1 online resource (129 pages)

Source: Dissertations Abstracts International, Volume: 84-12, Section: B.

Thesis (Ph.D.)--Harvard University, 2023.

Includes bibliographical references

Tactile sensation is mediated by low-threshold mechanoreceptors (LTMRs), which can exhibit highly distinct morphological and physiological properties depending on the skin type they innervate. Somatosensory neurons embryonically labeled with TrkB and Ret innervate glabrous (non-hairy) skin forming Meissner corpuscles, while in hairy skin, they form longitudinal lanceolate endings around hair follicles. How developing LTMRs acquire their unique properties in distinct skin types is unknown. Here, we report that structural specialization of hairy skin and glabrous skin LTMRs arises at nearly identical times during development. Interestingly, individual sensory neurons that terminate along the border of glabrous and hairy skin exhibit branches that form hair follicle lanceolate endings and others that form Meissner corpuscles. Using mouse mutants with ectopic glabrous skin on the dorsal paw, we found that LTMRs that innervate ectopic skin regions form endings in accordance with the altered skin type. Additionally, we report the transcriptional signatures of glabrous skin- and hairy skin-innervating TrkB+ and Ret+ neurons, which during development, largely overlap. Lastly, we characterize BMP5 as a skin-derived cue expressed specifically in glabrous skin but absent in hairy skin. Sensory neuron-specific deletion of the BMP type I receptor Bmpr1a led to strikingly aberrant Meissner corpuscles while hairy skin was intact. These findings indicate that embryonic LTMRs are able to form both Meissner corpuscles and lanceolate endings. It is the skin region that differentially instructs LTMRs to acquire skin type relevant structural properties during postnatal development, in part through BMP signaling. Thus, the specification of mechanosensory neuron features is flexibly determined by target tissues.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2023

Mode of access: World Wide Web

ISBN: 9798379612962Subjects--Topical Terms:

588700
Neurosciences.
Subjects--Index Terms:

MorphogenesisIndex Terms--Genre/Form:

542853
Electronic books.

Skin Type-Dependent Development of Specialized Mechanosensory Neurons.
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520 $a Tactile sensation is mediated by low-threshold mechanoreceptors (LTMRs), which can exhibit highly distinct morphological and physiological properties depending on the skin type they innervate. Somatosensory neurons embryonically labeled with TrkB and Ret innervate glabrous (non-hairy) skin forming Meissner corpuscles, while in hairy skin, they form longitudinal lanceolate endings around hair follicles. How developing LTMRs acquire their unique properties in distinct skin types is unknown. Here, we report that structural specialization of hairy skin and glabrous skin LTMRs arises at nearly identical times during development. Interestingly, individual sensory neurons that terminate along the border of glabrous and hairy skin exhibit branches that form hair follicle lanceolate endings and others that form Meissner corpuscles. Using mouse mutants with ectopic glabrous skin on the dorsal paw, we found that LTMRs that innervate ectopic skin regions form endings in accordance with the altered skin type. Additionally, we report the transcriptional signatures of glabrous skin- and hairy skin-innervating TrkB+ and Ret+ neurons, which during development, largely overlap. Lastly, we characterize BMP5 as a skin-derived cue expressed specifically in glabrous skin but absent in hairy skin. Sensory neuron-specific deletion of the BMP type I receptor Bmpr1a led to strikingly aberrant Meissner corpuscles while hairy skin was intact. These findings indicate that embryonic LTMRs are able to form both Meissner corpuscles and lanceolate endings. It is the skin region that differentially instructs LTMRs to acquire skin type relevant structural properties during postnatal development, in part through BMP signaling. Thus, the specification of mechanosensory neuron features is flexibly determined by target tissues.
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