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Regulatory Mechanisms of the Anti-cancer Cgamp-sting Pathway.
紀錄類型:
書目-電子資源 : Monograph/item
正題名/作者:
Regulatory Mechanisms of the Anti-cancer Cgamp-sting Pathway./
作者:
Ritchie, Christopher.
面頁冊數:
1 online resource (131 pages)
附註:
Source: Dissertations Abstracts International, Volume: 84-12, Section: B.
Contained By:
Dissertations Abstracts International84-12B.
標題:
Infections. -
電子資源:
http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30482722click for full text (PQDT)
ISBN:
9798379657185
Regulatory Mechanisms of the Anti-cancer Cgamp-sting Pathway.
Ritchie, Christopher.
Regulatory Mechanisms of the Anti-cancer Cgamp-sting Pathway.
- 1 online resource (131 pages)
Source: Dissertations Abstracts International, Volume: 84-12, Section: B.
Thesis (Ph.D.)--Stanford University, 2023.
Includes bibliographical references
Throughout our lifetimes, our bodies encounter a plethora of threats on the cellular level, including pathogen infection, cellular damage, and the development of cancer. When these threats are not properly detected, they can lead to serious health problems, including death. Thankfully, our cells are pre-programmed with an array of innate immune pathways that can quickly respond to threats by detecting specific molecular danger signals that indicate a threat is present. Of these innate immune pathways, the cGAMP-STING pathway is on the forefront of the immune response due to its ability to detect mislocalized double stranded DNA (dsDNA). Since mislocalized dsDNA is a danger signal nearly ubiquitous with cellular threats, the cGAMP-STING pathway is essential for responding to most threats, including pathogen infection, cellular damage, and cancer. Given the extensive role of the cGAMP-STING pathway in defending against threats, regulation of the pathway is crucial to ensure its proper function. In this work, I show how intercellular pathway activation is regulated through cell-type specific transporters of the pathway's agonist, cGAMP, and how intracellular pathway activation is regulated through the E3-ubiquitin ligase PELI2.
Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2023
Mode of access: World Wide Web
ISBN: 9798379657185Subjects--Topical Terms:
1621997
Infections.
Index Terms--Genre/Form:
542853
Electronic books.
Regulatory Mechanisms of the Anti-cancer Cgamp-sting Pathway.
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Throughout our lifetimes, our bodies encounter a plethora of threats on the cellular level, including pathogen infection, cellular damage, and the development of cancer. When these threats are not properly detected, they can lead to serious health problems, including death. Thankfully, our cells are pre-programmed with an array of innate immune pathways that can quickly respond to threats by detecting specific molecular danger signals that indicate a threat is present. Of these innate immune pathways, the cGAMP-STING pathway is on the forefront of the immune response due to its ability to detect mislocalized double stranded DNA (dsDNA). Since mislocalized dsDNA is a danger signal nearly ubiquitous with cellular threats, the cGAMP-STING pathway is essential for responding to most threats, including pathogen infection, cellular damage, and cancer. Given the extensive role of the cGAMP-STING pathway in defending against threats, regulation of the pathway is crucial to ensure its proper function. In this work, I show how intercellular pathway activation is regulated through cell-type specific transporters of the pathway's agonist, cGAMP, and how intracellular pathway activation is regulated through the E3-ubiquitin ligase PELI2.
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