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Evaluation of flexible PDL/LA based implants for sustained delivery of ciprofloxacin.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Evaluation of flexible PDL/LA based implants for sustained delivery of ciprofloxacin./
作者:	Waknis, Vrushali.
面頁冊數:	1 online resource (159 pages)
附註:	Source: Dissertations Abstracts International, Volume: 72-08, Section: B.
Contained By:	Dissertations Abstracts International72-08B.
標題:	Physical chemistry. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3435637click for full text (PQDT)
ISBN:	9781124340524

Evaluation of flexible PDL/LA based implants for sustained delivery of ciprofloxacin.
Waknis, Vrushali.

Evaluation of flexible PDL/LA based implants for sustained delivery of ciprofloxacin. - 1 online resource (159 pages)

Source: Dissertations Abstracts International, Volume: 72-08, Section: B.

Thesis (Ph.D.)--University of the Sciences in Philadelphia, 2010.

Includes bibliographical references

Infections in the skeletal system require high dose antibiotics for longer periods of time. Often poor perfusion at the site of infection/injury impair prognosis in many cases. In such instances localized delivery of antibiotics seems to be a better alternative. Conventional non-biodegradable delivery systems like poly methyl methacrylate (PMMA) beads loaded with antibiotics (Septopal®, Biomet, Finland) or PMMA cement require a second surgery for removal of the non biodegradable carrier. Using biodegradable polymers is more likely to improve patient compliance. Poly-DL/L-lactide (PDL/LA) is biodegradable polyester which forms lactic acid as it degrades. It is a rigid polymer with high compressive moduli often used in scaffolding applications. This rigidity often limits the use of PDL/LA in application which requires softer and more flexible delivery systems e.g. into incongruous necrotic tissue. Poly-ϵ-caprolactone (PCL) is also a polyester polymer biodegradable into 5-hydroxy caproic acids. PCL has a high elongation potential (300-500%) and is relatively less rigid than PLLA Copolymers of PDL/LA-PCL (8515LPCL, 7525LPCL and 7525DLPCL) have been investigated in this research for their potential use as biodegradable carriers for antibiotics applicable to such bone infections e.g. osteomyelitis. Comparison of copolymer properties to their respective homopolymers has also been achieved. Implants were designed for studies using three methods of fabrication - compression, heat molding and solvent evaporation-molding. Effect of implant design method on the thermo mechanical properties of the polymers was investigated. PLLA resulted in a threefold higher compressive modulus in heat molding vs. solvent evaporation-molding. Similarly these implants were also studied for their in vitro erosion properties and macrophage (CRL2192) adhesion. Thermo mechanical characterization, change in pH and gravimetric analysis was performed at every stage of erosion study. 7525DLPCL proved to have soft flexible consistency and lowest compressive modulus (0.1MPa). Additionally 7525DLPCL was completely amorphous throughout the study period and eroded over a period of 6 weeks. 7525DLPCL was selected for further studies which involved addition of an antibiotic - ciprofloxacin hydrochloride (CIP) at varying drug loadings and evaluation of drug release from the implants for a long period of time (12 weeks). Similarly macrophage adhesion was studied as a function of CIP loading. Thermal properties were also monitored for the 6 week period and % mass lost was determined. Release of CIP was modeled using various modified sigmoidal equations and best fit was adjudged. These studies indicate good prospects of developing 7525DLPCL based soft tissue delivery systems which could be used in incongruous necrotic cavities. Investigated system appears to have requisite thermo mechanical characteristics and in vitro erosion properties which could be used for skeletal drug delivery.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2023

Mode of access: World Wide Web

ISBN: 9781124340524Subjects--Topical Terms:

1981412
Physical chemistry.
Subjects--Index Terms:

CiprofloxacinIndex Terms--Genre/Form:

542853
Electronic books.

Evaluation of flexible PDL/LA based implants for sustained delivery of ciprofloxacin.
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504 $a Includes bibliographical references
520 $a Infections in the skeletal system require high dose antibiotics for longer periods of time. Often poor perfusion at the site of infection/injury impair prognosis in many cases. In such instances localized delivery of antibiotics seems to be a better alternative. Conventional non-biodegradable delivery systems like poly methyl methacrylate (PMMA) beads loaded with antibiotics (Septopal®, Biomet, Finland) or PMMA cement require a second surgery for removal of the non biodegradable carrier. Using biodegradable polymers is more likely to improve patient compliance. Poly-DL/L-lactide (PDL/LA) is biodegradable polyester which forms lactic acid as it degrades. It is a rigid polymer with high compressive moduli often used in scaffolding applications. This rigidity often limits the use of PDL/LA in application which requires softer and more flexible delivery systems e.g. into incongruous necrotic tissue. Poly-ϵ-caprolactone (PCL) is also a polyester polymer biodegradable into 5-hydroxy caproic acids. PCL has a high elongation potential (300-500%) and is relatively less rigid than PLLA Copolymers of PDL/LA-PCL (8515LPCL, 7525LPCL and 7525DLPCL) have been investigated in this research for their potential use as biodegradable carriers for antibiotics applicable to such bone infections e.g. osteomyelitis. Comparison of copolymer properties to their respective homopolymers has also been achieved. Implants were designed for studies using three methods of fabrication - compression, heat molding and solvent evaporation-molding. Effect of implant design method on the thermo mechanical properties of the polymers was investigated. PLLA resulted in a threefold higher compressive modulus in heat molding vs. solvent evaporation-molding. Similarly these implants were also studied for their in vitro erosion properties and macrophage (CRL2192) adhesion. Thermo mechanical characterization, change in pH and gravimetric analysis was performed at every stage of erosion study. 7525DLPCL proved to have soft flexible consistency and lowest compressive modulus (0.1MPa). Additionally 7525DLPCL was completely amorphous throughout the study period and eroded over a period of 6 weeks. 7525DLPCL was selected for further studies which involved addition of an antibiotic - ciprofloxacin hydrochloride (CIP) at varying drug loadings and evaluation of drug release from the implants for a long period of time (12 weeks). Similarly macrophage adhesion was studied as a function of CIP loading. Thermal properties were also monitored for the 6 week period and % mass lost was determined. Release of CIP was modeled using various modified sigmoidal equations and best fit was adjudged. These studies indicate good prospects of developing 7525DLPCL based soft tissue delivery systems which could be used in incongruous necrotic cavities. Investigated system appears to have requisite thermo mechanical characteristics and in vitro erosion properties which could be used for skeletal drug delivery.
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