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Interactions between the Hippocampus and Prefrontal Cortex in Context-Dependent Overlapping Memory Retrieval.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Interactions between the Hippocampus and Prefrontal Cortex in Context-Dependent Overlapping Memory Retrieval./
作者:	Cohen, Justine E.
面頁冊數:	1 online resource (155 pages)
附註:	Source: Dissertations Abstracts International, Volume: 80-05, Section: B.
Contained By:	Dissertations Abstracts International80-05B.
標題:	Neurosciences. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10787338click for full text (PQDT)
ISBN:	9780438675155

Interactions between the Hippocampus and Prefrontal Cortex in Context-Dependent Overlapping Memory Retrieval.
Cohen, Justine E.

Interactions between the Hippocampus and Prefrontal Cortex in Context-Dependent Overlapping Memory Retrieval. - 1 online resource (155 pages)

Source: Dissertations Abstracts International, Volume: 80-05, Section: B.

Thesis (Ph.D.)--Boston University, 2018.

Includes bibliographical references

Activation in the hippocampus (HC) and prefrontal cortex (PFC) is critical to accurately retrieve overlapping sequences. Experiments 1 and 2 tested the hypotheses that activation in and interaction between HC and PFC increases as overlap between sequences increases in a non-spatial task. Experiment 3 tested the hypothesis that theta oscillations are involved in orchestrating interactions between HC and PFC in a spatial task with overlapping elements. In the first two studies, 17 participants (aged 18-34; 11 female) learned sequences consisting of a picture frame, face, and scene. Conditions varied by degree of overlap. Using fMRI, Experiment 1 tested how degree of overlap affected HC and PFC activation. In overlapping sequences, middle and posterior HC were active when predictability of the correct response increased, dorsolateral PFC was active when participants were able to ascertain the correct set of sequences, and ventrolateral PFC was active when inhibition of interfering associations was required. Experiment 2 examined functional connectivity of HC and PFC during disambiguation. Low- and high-overlap conditions were associated with increased connectivity in separate regions at different times indicating that retrieval under the two conditions used different neural networks and strategies. Low-overlap trials were associated with increased connectivity between HC and prefrontal and parietal regions. High-overlap trials showed increased connectivity between lateral PFC and visual areas, indicating that imagery may be necessary for accurate performance. Using EEG recording, Experiment 3 examined theta activity during retrieval of well-learned, overlapping and non-overlapping mazes in 17 participants (aged 18-34, 11 female). Theta activity increased in overlapping mazes during the first of four hallways, suggesting participants were looking ahead to upcoming turns in the maze. Theta activity increased at the beginning and choice point of the third overlapping hallway, possibly in response to interference from the paired, overlapping maze. These studies provide evidence that (1) overlapping associations in non-spatial sequences elicit interactions between hippocampus and lateral prefrontal cortex, (2) increasing the degree of overlap changes the neural processes required to perform the task, and (3) theta power increases in response to increased cognitive demand and maintenance of sequence information needed to differentiate between overlapping spatial routes.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2023

Mode of access: World Wide Web

ISBN: 9780438675155Subjects--Topical Terms:

588700
Neurosciences.
Subjects--Index Terms:

Context-dependentIndex Terms--Genre/Form:

542853
Electronic books.

Interactions between the Hippocampus and Prefrontal Cortex in Context-Dependent Overlapping Memory Retrieval.
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