東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

FindBook

Google Book

Amazon

博客來

Investigating the Role of the Hippocampus in Remote Memory Retrieval.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Investigating the Role of the Hippocampus in Remote Memory Retrieval./
作者:	Hamidi, Anahita Bahiyyih.
面頁冊數:	1 online resource (90 pages)
附註:	Source: Dissertations Abstracts International, Volume: 79-06, Section: B.
Contained By:	Dissertations Abstracts International79-06B.
標題:	Neurosciences. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10621809click for full text (PQDT)
ISBN:	9780355461749

Investigating the Role of the Hippocampus in Remote Memory Retrieval.
Hamidi, Anahita Bahiyyih.

Investigating the Role of the Hippocampus in Remote Memory Retrieval. - 1 online resource (90 pages)

Source: Dissertations Abstracts International, Volume: 79-06, Section: B.

Thesis (Ph.D.)--University of California, Davis, 2017.

Includes bibliographical references

According to the theory of systems consolidation, the brain circuits required to successfully retrieve a memory depend on the age of the memory itself (Squire, 1992; Squire and Alvarez, 1995). Specifically, the theory claims that newer (recent) memories are hippocampal dependent while older (remote) memories are hippocampal independent. Our group recently provided direct evidence (Tanaka et al., 2014) that reactivation of a specific ensemble of hippocampal neurons is necessary for the successful retrieval of a recent (2-day) memory. In the present study, I aimed to silence a specific hippocampal ensemble (i.e. selectively silence) at a remote (14-day) time point using both optogenetic (Chapter 2) and pharmacological (Chapter 3) methods. The optogenetic silencing condition impaired remote memory retrieval, whereas the pharmacological manipulation did not. However, imaging of brain tissue revealed that the optogenetic manipulation resulted in non-selective silencing. Thus, I performed follow-up experiments to test first, whether altering the doxycycline dosage could rescue the non- selective silencing (Chapter 4.1) and second, whether I could replicate the findings of others who have done prolonged, non-selective hippocampal silencing (Chapter 4.2).

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2023

Mode of access: World Wide Web

ISBN: 9780355461749Subjects--Topical Terms:

588700
Neurosciences.
Subjects--Index Terms:

HippocampusIndex Terms--Genre/Form:

542853
Electronic books.

Investigating the Role of the Hippocampus in Remote Memory Retrieval.
LDR:02674nmm a2200409K 4500 001 2360450
005 20230928115638.5
006 m o d
007 cr mn ---uuuuu
008 241011s2017 xx obm 000 0 eng d
020 $a 9780355461749
035 $a (MiAaPQ)AAI10621809
035 $a (MiAaPQ)ucdavis:17267
035 $a AAI10621809
040 $a MiAaPQ $b eng $c MiAaPQ $d NTU
100 1 $a Hamidi, Anahita Bahiyyih. $3 3701071
245 1 0 $a Investigating the Role of the Hippocampus in Remote Memory Retrieval.
264 0 $c 2017
300 $a 1 online resource (90 pages)
336 $a text $b txt $2 rdacontent
337 $a computer $b c $2 rdamedia
338 $a online resource $b cr $2 rdacarrier
500 $a Source: Dissertations Abstracts International, Volume: 79-06, Section: B.
500 $a Publisher info.: Dissertation/Thesis.
500 $a Advisor: Ekstrom, Arne.
502 $a Thesis (Ph.D.)--University of California, Davis, 2017.
504 $a Includes bibliographical references
520 $a According to the theory of systems consolidation, the brain circuits required to successfully retrieve a memory depend on the age of the memory itself (Squire, 1992; Squire and Alvarez, 1995). Specifically, the theory claims that newer (recent) memories are hippocampal dependent while older (remote) memories are hippocampal independent. Our group recently provided direct evidence (Tanaka et al., 2014) that reactivation of a specific ensemble of hippocampal neurons is necessary for the successful retrieval of a recent (2-day) memory. In the present study, I aimed to silence a specific hippocampal ensemble (i.e. selectively silence) at a remote (14-day) time point using both optogenetic (Chapter 2) and pharmacological (Chapter 3) methods. The optogenetic silencing condition impaired remote memory retrieval, whereas the pharmacological manipulation did not. However, imaging of brain tissue revealed that the optogenetic manipulation resulted in non-selective silencing. Thus, I performed follow-up experiments to test first, whether altering the doxycycline dosage could rescue the non- selective silencing (Chapter 4.1) and second, whether I could replicate the findings of others who have done prolonged, non-selective hippocampal silencing (Chapter 4.2).
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2023
538 $a Mode of access: World Wide Web
650 4 $a Neurosciences. $3 588700
650 4 $a Psychobiology. $3 555678
650 4 $a Behavioral psychology. $3 2122788
653 $a Hippocampus
653 $a Memory
653 $a Optogenetics
653 $a Retrieval
655 7 $a Electronic books. $2 lcsh $3 542853
690 $a 0317
690 $a 0349
690 $a 0384
710 2 $a ProQuest Information and Learning Co. $3 783688
710 2 $a University of California, Davis. $b Neuroscience. $3 3168776
773 0 $t Dissertations Abstracts International $g 79-06B.
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10621809 $z click for full text (PQDT)