東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

FindBook

Google Book

Amazon

博客來

Immune Polyphony : = Dissecting Coordinated Multicellular Networks of Antiviral Immunity.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Immune Polyphony :/
其他題名:	Dissecting Coordinated Multicellular Networks of Antiviral Immunity.
作者:	Wilk, Aaron James.
面頁冊數:	1 online resource (330 pages)
附註:	Source: Dissertations Abstracts International, Volume: 84-04, Section: B.
Contained By:	Dissertations Abstracts International84-04B.
標題:	Infections. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=29408071click for full text (PQDT)
ISBN:	9798352655672

Immune Polyphony : = Dissecting Coordinated Multicellular Networks of Antiviral Immunity.
Wilk, Aaron James.

Immune Polyphony :Dissecting Coordinated Multicellular Networks of Antiviral Immunity. - 1 online resource (330 pages)

Source: Dissertations Abstracts International, Volume: 84-04, Section: B.

Thesis (Ph.D.)--Stanford University, 2022.

Includes bibliographical references

Viral diseases remain a major cause of morbidity and mortality worldwide and emerging viral pathogens represent a perennial threat to human health. The rapidity, quality, and duration of the immune response to a viral pathogen is a major determinant of disease outcome in viral disease. This immune response to a viral pathogen involves the activity of multiple cell types with distinct and multifaceted functional roles to mount a response that is appropriate in both time and space. An insufficient response may result in unrestrained viral replication while an overly robust response can result in direct tissue damage. Thus, an effectively regulated antiviral immune response requires complex coordination, communication, and regulation between individual immune cells. We coin the term "immune polyphony" to describe these coordinated multicellular networks -- a reference to musical polyphony where multiple individual voices come together to create harmony.Here we present a framework to study and engineer immune polyphony and apply this framework to dissect the features of well-balanced immune responses in multiple viral diseases. First, we examine immune responses in patients with COVID-19 across the full range of the disease severity spectrum to reveal widespread dysregulation of innate immunity in severe COVID-19. Next, we introduce a novel computational framework for the analysis of cell-cell communication pathways at the resolution of the single-cell. We then apply this methodology to analyze inflammatory networks that distinguish immune responses to pathogenic vs. non-pathogenic lentiviruses. Finally, we describe a technique for bio-orthogonal manipulation of primary immune cells, thus providing a pathway for future efforts to engineer polyphonic immune responses to promote effective antiviral immunity.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2023

Mode of access: World Wide Web

ISBN: 9798352655672Subjects--Topical Terms:

1621997
Infections.
Index Terms--Genre/Form:

542853
Electronic books.

Immune Polyphony : = Dissecting Coordinated Multicellular Networks of Antiviral Immunity.
LDR:03322nmm a2200421K 4500 001 2359851
005 20230917195304.5
006 m o d
007 cr mn ---uuuuu
008 241011s2022 xx obm 000 0 eng d
020 $a 9798352655672
035 $a (MiAaPQ)AAI29408071
035 $a (MiAaPQ)STANFORDfx947zj9187
035 $a AAI29408071
040 $a MiAaPQ $b eng $c MiAaPQ $d NTU
100 1 $a Wilk, Aaron James. $3 3700464
245 1 0 $a Immune Polyphony : $b Dissecting Coordinated Multicellular Networks of Antiviral Immunity.
264 0 $c 2022
300 $a 1 online resource (330 pages)
336 $a text $b txt $2 rdacontent
337 $a computer $b c $2 rdamedia
338 $a online resource $b cr $2 rdacarrier
500 $a Source: Dissertations Abstracts International, Volume: 84-04, Section: B.
500 $a Includes supplementary digital materials.
500 $a Advisor: Bintu, Lacramioara; Greenleaf, William James; Kim, Peter; Krams, Sheri Michele.
502 $a Thesis (Ph.D.)--Stanford University, 2022.
504 $a Includes bibliographical references
520 $a Viral diseases remain a major cause of morbidity and mortality worldwide and emerging viral pathogens represent a perennial threat to human health. The rapidity, quality, and duration of the immune response to a viral pathogen is a major determinant of disease outcome in viral disease. This immune response to a viral pathogen involves the activity of multiple cell types with distinct and multifaceted functional roles to mount a response that is appropriate in both time and space. An insufficient response may result in unrestrained viral replication while an overly robust response can result in direct tissue damage. Thus, an effectively regulated antiviral immune response requires complex coordination, communication, and regulation between individual immune cells. We coin the term "immune polyphony" to describe these coordinated multicellular networks -- a reference to musical polyphony where multiple individual voices come together to create harmony.Here we present a framework to study and engineer immune polyphony and apply this framework to dissect the features of well-balanced immune responses in multiple viral diseases. First, we examine immune responses in patients with COVID-19 across the full range of the disease severity spectrum to reveal widespread dysregulation of innate immunity in severe COVID-19. Next, we introduce a novel computational framework for the analysis of cell-cell communication pathways at the resolution of the single-cell. We then apply this methodology to analyze inflammatory networks that distinguish immune responses to pathogenic vs. non-pathogenic lentiviruses. Finally, we describe a technique for bio-orthogonal manipulation of primary immune cells, thus providing a pathway for future efforts to engineer polyphonic immune responses to promote effective antiviral immunity.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2023
538 $a Mode of access: World Wide Web
650 4 $a Infections. $3 1621997
650 4 $a Pathogens. $3 3540520
650 4 $a Chemokines. $3 702040
650 4 $a Communication. $3 524709
650 4 $a Cytotoxicity. $3 3682273
650 4 $a Disease. $3 705846
650 4 $a Cytokines. $3 687114
650 4 $a Immunology. $3 611031
650 4 $a Flow cytometry. $3 600581
650 4 $a Blood & organ donations. $3 3682171
650 4 $a Immune system. $3 689864
650 4 $a Genetic engineering. $3 530509
650 4 $a Medical research. $2 bicssc $3 1556686
650 4 $a Lymphocytes. $3 895384
650 4 $a Sociology. $3 516174
650 4 $a Viruses. $3 571474
650 4 $a Viral infections. $3 3540521
650 4 $a Coronaviruses. $3 894828
650 4 $a Interferon. $3 671927
650 4 $a Bioengineering. $3 657580
650 4 $a Cellular biology. $3 3172791
650 4 $a Genetics. $3 530508
650 4 $a Medicine. $3 641104
650 4 $a Pharmaceutical sciences. $3 3173021
655 7 $a Electronic books. $2 lcsh $3 542853
690 $a 0982
690 $a 0626
690 $a 0459
690 $a 0202
690 $a 0379
690 $a 0369
690 $a 0564
690 $a 0572
710 2 $a ProQuest Information and Learning Co. $3 783688
710 2 $a Stanford University. $3 754827
773 0 $t Dissertations Abstracts International $g 84-04B.
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=29408071 $z click for full text (PQDT)