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Reprogramming Cancer into Antigen Presenting Cells as a Novel Immunotherapy.
紀錄類型:
書目-電子資源 : Monograph/item
正題名/作者:
Reprogramming Cancer into Antigen Presenting Cells as a Novel Immunotherapy./
作者:
Linde, Miles Hamilton.
面頁冊數:
1 online resource (72 pages)
附註:
Source: Dissertations Abstracts International, Volume: 84-04, Section: B.
Contained By:
Dissertations Abstracts International84-04B.
標題:
Cytokines. -
電子資源:
http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=29342299click for full text (PQDT)
ISBN:
9798351496498
Reprogramming Cancer into Antigen Presenting Cells as a Novel Immunotherapy.
Linde, Miles Hamilton.
Reprogramming Cancer into Antigen Presenting Cells as a Novel Immunotherapy.
- 1 online resource (72 pages)
Source: Dissertations Abstracts International, Volume: 84-04, Section: B.
Thesis (Ph.D.)--Stanford University, 2022.
Includes bibliographical references
Therapeutic cancer vaccination seeks to elicit activation of tumor-reactive T cells capable of recognizing tumor-associated antigens (TAAs) and eradicating malignant cells. Here, we present a cancer vaccination approach utilizing myeloid lineage reprogramming to directly convert cancer cells into tumor reprogrammed-APCs (TR-APCs). Using syngeneic murine leukemia models, we demonstrate that TR-APCs acquire both myeloid phenotype and function, process and present endogenous TAAs, and potently stimulate TAA-specific CD4+ and CD8+ T cells. In vivo TR-APC induction elicits clonal expansion of cancer-specific T cells, establishes cancer-specific immune memory, and ultimately promotes leukemia eradication. We further show that both hematologic cancers and solid tumors, including sarcomas and carcinomas, are amenable to myeloid-lineage reprogramming into TR-APCs. Finally, we demonstrate the clinical applicability of this approach by generating TR-APCs from primary clinical specimens and stimulating autologous patient-derived T cells. Thus, TR-APCs represent a cancer vaccination therapeutic strategy with broad implications for clinical immuno-oncology.
Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2023
Mode of access: World Wide Web
ISBN: 9798351496498Subjects--Topical Terms:
687114
Cytokines.
Index Terms--Genre/Form:
542853
Electronic books.
Reprogramming Cancer into Antigen Presenting Cells as a Novel Immunotherapy.
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Therapeutic cancer vaccination seeks to elicit activation of tumor-reactive T cells capable of recognizing tumor-associated antigens (TAAs) and eradicating malignant cells. Here, we present a cancer vaccination approach utilizing myeloid lineage reprogramming to directly convert cancer cells into tumor reprogrammed-APCs (TR-APCs). Using syngeneic murine leukemia models, we demonstrate that TR-APCs acquire both myeloid phenotype and function, process and present endogenous TAAs, and potently stimulate TAA-specific CD4+ and CD8+ T cells. In vivo TR-APC induction elicits clonal expansion of cancer-specific T cells, establishes cancer-specific immune memory, and ultimately promotes leukemia eradication. We further show that both hematologic cancers and solid tumors, including sarcomas and carcinomas, are amenable to myeloid-lineage reprogramming into TR-APCs. Finally, we demonstrate the clinical applicability of this approach by generating TR-APCs from primary clinical specimens and stimulating autologous patient-derived T cells. Thus, TR-APCs represent a cancer vaccination therapeutic strategy with broad implications for clinical immuno-oncology.
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