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Causal Inference in Psychiatry Research.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Causal Inference in Psychiatry Research./
作者:	Szmulewicz, Alejandro.
面頁冊數:	1 online resource (96 pages)
附註:	Source: Dissertations Abstracts International, Volume: 83-12, Section: B.
Contained By:	Dissertations Abstracts International83-12B.
標題:	Epidemiology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=29210406click for full text (PQDT)
ISBN:	9798819383254

Causal Inference in Psychiatry Research.
Szmulewicz, Alejandro.

Causal Inference in Psychiatry Research. - 1 online resource (96 pages)

Source: Dissertations Abstracts International, Volume: 83-12, Section: B.

Thesis (Ph.D.)--Harvard University, 2022.

Includes bibliographical references

In Chapter 1, we show how to emulate a hypothetical randomized trial ("target trial") that would answer our questions about the comparative effectiveness of complex dynamic treatment strategies in major depression using inverse probability weighting. We finally show that using the strategy proposed by most clinical guidelines was associated with an increased probability of remission and a lower risk of serious adverse events.In chapter 2, we underscore the importance of incorporating the per-protocol effect as a causal estimand of interest in randomized trials in psychiatry. We used data from a recent randomized trial to estimate the per-protocol effect of lithium on suicidality. Our analyses showed that the 12-month risk of suicidality under the lithium strategy was 6.7 percentage points lower than for placebo, with values between 19.2 percentage points lower and 5.9 percentage points higher were very compatible with our data. Our results suggest that lithium might be effective in preventing suicidality after adjusting for nonadherence, but our confidence intervals were wide.In Chapter 3, we introduce the FEP-CAUSAL Collaboration, an international consortium of observational cohorts from patients with a First Episode of Psychosis (FEP). We used data from this consortium to compare the effect estimates from a well-known randomized trial (the EUFEST trial) against the emulation of a target trial with the same protocol using the observational data, a process that is called benchmarking. From this experience, we report the strengths and limitations of our dataset to emulate target trials in early psychosis.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2023

Mode of access: World Wide Web

ISBN: 9798819383254Subjects--Topical Terms:

568544
Epidemiology.
Subjects--Index Terms:

BiostatisticsIndex Terms--Genre/Form:

542853
Electronic books.

Causal Inference in Psychiatry Research.
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500 $a Source: Dissertations Abstracts International, Volume: 83-12, Section: B.
500 $a Advisor: Hernan, Miguel A.
502 $a Thesis (Ph.D.)--Harvard University, 2022.
504 $a Includes bibliographical references
520 $a In Chapter 1, we show how to emulate a hypothetical randomized trial ("target trial") that would answer our questions about the comparative effectiveness of complex dynamic treatment strategies in major depression using inverse probability weighting. We finally show that using the strategy proposed by most clinical guidelines was associated with an increased probability of remission and a lower risk of serious adverse events.In chapter 2, we underscore the importance of incorporating the per-protocol effect as a causal estimand of interest in randomized trials in psychiatry. We used data from a recent randomized trial to estimate the per-protocol effect of lithium on suicidality. Our analyses showed that the 12-month risk of suicidality under the lithium strategy was 6.7 percentage points lower than for placebo, with values between 19.2 percentage points lower and 5.9 percentage points higher were very compatible with our data. Our results suggest that lithium might be effective in preventing suicidality after adjusting for nonadherence, but our confidence intervals were wide.In Chapter 3, we introduce the FEP-CAUSAL Collaboration, an international consortium of observational cohorts from patients with a First Episode of Psychosis (FEP). We used data from this consortium to compare the effect estimates from a well-known randomized trial (the EUFEST trial) against the emulation of a target trial with the same protocol using the observational data, a process that is called benchmarking. From this experience, we report the strengths and limitations of our dataset to emulate target trials in early psychosis.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2023
538 $a Mode of access: World Wide Web
650 4 $a Epidemiology. $3 568544
650 4 $a Mental health. $3 534751
653 $a Biostatistics
653 $a Depression
653 $a Psychosis
653 $a Suicide
655 7 $a Electronic books. $2 lcsh $3 542853
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