東華大學圖書館 |

The Darwin Prospective Melioidosis Study.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	The Darwin Prospective Melioidosis Study./
作者:	Currie, Bart.
面頁冊數:	1 online resource (213 pages)
附註:	Source: Dissertations Abstracts International, Volume: 84-06, Section: B.
Contained By:	Dissertations Abstracts International84-06B.
標題:	Microbiology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30163377click for full text (PQDT)
ISBN:	9798358405066

The Darwin Prospective Melioidosis Study.
Currie, Bart.

The Darwin Prospective Melioidosis Study. - 1 online resource (213 pages)

Source: Dissertations Abstracts International, Volume: 84-06, Section: B.

Thesis (Ph.D.)--Charles Darwin University (Australia), 2022.

Includes bibliographical references

The Darwin Prospective Melioidosis Study (DPMS) commenced on October 1st, 1989. Over 30 years to September 30th, 2019, there were 1148 individuals with Burkholderia pseudomallei culture-positive melioidosis, of whom 133 (12%) died. Median age was 50 years (IQR 38-60), 48 (4%) study participants were children younger than 15 years of age, 721 (63%) were male individuals, and 600 (52%) First Nations Australians. All but 186 (16%) had clinical risk factors, 513 (45%) had diabetes, and 455 (40%) hazardous alcohol use. Only three (2%) of 133 fatalities had no identified clinical risk factor. Of 1148 primary melioidosis presentations, 1013 (88%) were acute (with an incubation period of 1-21 days, median 4 days, IQR 3-7 days), 106 (9%) were chronic (defined as symptoms for ≥ 2months), and 29 (3%) were considered to be infection activations from latency. 60 (5%) individuals had one or more recurrences of melioidosis, of whom 44 individuals had a relapse and 20 individuals had a new infection, making a total of 1212 episodes of melioidosis over the 30 years. Pneumonia was the most common presentation occurring in 595 (52%) patients. Bacteraemia occurred in 633 (56%) of 1135 patients, septic shock in 240 (21%) patients, and 180 (16%) patients required mechanical ventilation. Cases correlated with rainfall, with 80% of infections occurring during the wet season (November to April). Median annual incidence was 20·5 cases per 100,000 people; the highest annual incidence in First Nations Australians was 103·6 per 100,000 in 2011-12. Over the 30 years, annual incidences increased, as did the proportion of patients with diabetes, although mortality decreased to 17 (6%) of 278 patients over the last 5 years.Genotyping of B. pseudomallei at Menzies School of Health Research evolved from ribotyping in the early days, to pulsed-field gel electrophoresis and BOX-PCR. With the advent of direct genome sequencing, Menzies embraced multilocus sequence typing (MLST) and more recently analysis of whole genome sequencing of B. pseudomallei DNA. Menzies curates the open access global B. pseudomallei MLST website;Of the 1148 primary presentations, we have stored B. pseudomallei isolates and MLST results from 1108 (97%). There were 349 distinct B. pseudomallei sequence types (STs), of which 243 were found only in a single patient. The large diversity of sequence types was especially evident in rural and remote Top End regions. In urban Darwin there was a dynamic situation of persistence throughout the 30 years of common STs 36, 109 and 132, while ST 553 was rare in early years but increased to become the commonest ST in Darwin in the last 5 years. The proliferation of ST 553 is linked to a period of intense urban construction. An evolving story is the likely point source introduction into Darwin of an Asian genotype ST 562, which continues to spread. How this introduction occurred and specifically where from remain to be established.Genotyping has provided important insights into the epidemiology of melioidosis, enabling linking of B. pseudomallei from individual cases to environmental B. pseudomallei recovered from specific potential exposure sites. One notable example is matching a B. pseudomallei genotype from air sampling during stormy weather to the genotype from an individual with presumptive inhalational melioidosis. Case clusters linked to contaminated water supplies have also been confirmed by genotyping.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2023

Mode of access: World Wide Web

ISBN: 9798358405066Subjects--Topical Terms:

536250
Microbiology.
Index Terms--Genre/Form:

542853
Electronic books.

The Darwin Prospective Melioidosis Study.
LDR:04848nmm a2200421K 4500 001 2359085
005 20230906055310.5
006 m o d
007 cr mn ---uuuuu
008 241011s2022 xx obm 000 0 eng d
020 $a 9798358405066
035 $a (MiAaPQ)AAI30163377
035 $a (MiAaPQ)CharlesDarwin8711fdbfbd464905a13e859822f157ed
035 $a AAI30163377
040 $a MiAaPQ $b eng $c MiAaPQ $d NTU
100 1 $a Currie, Bart. $3 3699652
245 1 4 $a The Darwin Prospective Melioidosis Study.
264 0 $c 2022
300 $a 1 online resource (213 pages)
336 $a text $b txt $2 rdacontent
337 $a computer $b c $2 rdamedia
338 $a online resource $b cr $2 rdacarrier
500 $a Source: Dissertations Abstracts International, Volume: 84-06, Section: B.
500 $a Advisor: Anstey, Supervisor Nicholas.
502 $a Thesis (Ph.D.)--Charles Darwin University (Australia), 2022.
504 $a Includes bibliographical references
520 $a The Darwin Prospective Melioidosis Study (DPMS) commenced on October 1st, 1989. Over 30 years to September 30th, 2019, there were 1148 individuals with Burkholderia pseudomallei culture-positive melioidosis, of whom 133 (12%) died. Median age was 50 years (IQR 38-60), 48 (4%) study participants were children younger than 15 years of age, 721 (63%) were male individuals, and 600 (52%) First Nations Australians. All but 186 (16%) had clinical risk factors, 513 (45%) had diabetes, and 455 (40%) hazardous alcohol use. Only three (2%) of 133 fatalities had no identified clinical risk factor. Of 1148 primary melioidosis presentations, 1013 (88%) were acute (with an incubation period of 1-21 days, median 4 days, IQR 3-7 days), 106 (9%) were chronic (defined as symptoms for ≥ 2months), and 29 (3%) were considered to be infection activations from latency. 60 (5%) individuals had one or more recurrences of melioidosis, of whom 44 individuals had a relapse and 20 individuals had a new infection, making a total of 1212 episodes of melioidosis over the 30 years. Pneumonia was the most common presentation occurring in 595 (52%) patients. Bacteraemia occurred in 633 (56%) of 1135 patients, septic shock in 240 (21%) patients, and 180 (16%) patients required mechanical ventilation. Cases correlated with rainfall, with 80% of infections occurring during the wet season (November to April). Median annual incidence was 20·5 cases per 100,000 people; the highest annual incidence in First Nations Australians was 103·6 per 100,000 in 2011-12. Over the 30 years, annual incidences increased, as did the proportion of patients with diabetes, although mortality decreased to 17 (6%) of 278 patients over the last 5 years.Genotyping of B. pseudomallei at Menzies School of Health Research evolved from ribotyping in the early days, to pulsed-field gel electrophoresis and BOX-PCR. With the advent of direct genome sequencing, Menzies embraced multilocus sequence typing (MLST) and more recently analysis of whole genome sequencing of B. pseudomallei DNA. Menzies curates the open access global B. pseudomallei MLST website;Of the 1148 primary presentations, we have stored B. pseudomallei isolates and MLST results from 1108 (97%). There were 349 distinct B. pseudomallei sequence types (STs), of which 243 were found only in a single patient. The large diversity of sequence types was especially evident in rural and remote Top End regions. In urban Darwin there was a dynamic situation of persistence throughout the 30 years of common STs 36, 109 and 132, while ST 553 was rare in early years but increased to become the commonest ST in Darwin in the last 5 years. The proliferation of ST 553 is linked to a period of intense urban construction. An evolving story is the likely point source introduction into Darwin of an Asian genotype ST 562, which continues to spread. How this introduction occurred and specifically where from remain to be established.Genotyping has provided important insights into the epidemiology of melioidosis, enabling linking of B. pseudomallei from individual cases to environmental B. pseudomallei recovered from specific potential exposure sites. One notable example is matching a B. pseudomallei genotype from air sampling during stormy weather to the genotype from an individual with presumptive inhalational melioidosis. Case clusters linked to contaminated water supplies have also been confirmed by genotyping.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2023
538 $a Mode of access: World Wide Web
650 4 $a Microbiology. $3 536250
650 4 $a Infections. $3 1621997
650 4 $a Infectious diseases. $3 2179310
650 4 $a Water supply. $3 736103
650 4 $a Documentation. $3 774384
650 4 $a Dance. $3 610547
650 4 $a Epidemiology. $3 568544
650 4 $a Floods. $3 549458
650 4 $a Mortality. $3 533218
650 4 $a Hospitals. $3 616081
650 4 $a Genomes. $3 592593
650 4 $a Genomics. $3 600531
650 4 $a Genetic diversity. $3 3685454
650 4 $a Patients. $3 1961957
650 4 $a Epidemics. $3 588395
650 4 $a World War II. $3 3303653
650 4 $a Public health. $3 534748
650 4 $a Pathogenesis. $3 3561735
650 4 $a Tuberculosis. $3 808530
650 4 $a Biology. $3 522710
650 4 $a Evolution & development. $3 3172418
650 4 $a Genetics. $3 530508
650 4 $a Military history. $3 552332
650 4 $a Performing arts. $3 523119
655 7 $a Electronic books. $2 lcsh $3 542853
690 $a 0573
690 $a 0766
690 $a 0378
690 $a 0410
690 $a 0306
690 $a 0412
690 $a 0369
690 $a 0722
690 $a 0641
710 2 $a ProQuest Information and Learning Co. $3 783688
710 2 $a Charles Darwin University (Australia). $3 3681337
773 0 $t Dissertations Abstracts International $g 84-06B.
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30163377 $z click for full text (PQDT)