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Tissue Bioeffects during Ultrasound-mediated Drug Delivery.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Tissue Bioeffects during Ultrasound-mediated Drug Delivery./
作者:	Sutton, Jonathan.
面頁冊數:	1 online resource (146 pages)
附註:	Source: Dissertations Abstracts International, Volume: 76-02, Section: B.
Contained By:	Dissertations Abstracts International76-02B.
標題:	Biomedical engineering. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3625834click for full text (PQDT)
ISBN:	9781321001952

Tissue Bioeffects during Ultrasound-mediated Drug Delivery.
Sutton, Jonathan.

Tissue Bioeffects during Ultrasound-mediated Drug Delivery. - 1 online resource (146 pages)

Source: Dissertations Abstracts International, Volume: 76-02, Section: B.

Thesis (Ph.D.)--University of Cincinnati, 2014.

Includes bibliographical references

Ultrasound has been developed as both a valuable diagnostic tool and a potent promoter of beneficial tissue bioeffects for the treatment of cardiovascular disease. Vascular effects can be mediated by mechanical oscillations of circulating microbubbles, or ultrasound contrast agents, which may also encapsulate and shield a therapeutic agent in the bloodstream. Oscillating microbubbles can create stresses directly on nearby tissue or induce fluid effects that effect drug penetration into vascular tissue, lyse thrombi, or direct drugs to optimal locations for delivery. These investigations have spurred continued research into alternative therapeutic applications, such as bioactive gas delivery. This dissertation addresses a fundamental hypothesis in biomedical ultrasound: ultrasound-mediated drug delivery is capable of increasing the penetration of drugs across different physiologic barriers within the cardiovascular system, such as the vascular endothelium, blood clots, and smooth muscle cells.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2023

Mode of access: World Wide Web

ISBN: 9781321001952Subjects--Topical Terms:

535387
Biomedical engineering.
Subjects--Index Terms:

Bioactive gasIndex Terms--Genre/Form:

542853
Electronic books.

Tissue Bioeffects during Ultrasound-mediated Drug Delivery.
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500 $a Source: Dissertations Abstracts International, Volume: 76-02, Section: B.
500 $a Publisher info.: Dissertation/Thesis.
500 $a Advisor: Holland, Christy K.
502 $a Thesis (Ph.D.)--University of Cincinnati, 2014.
504 $a Includes bibliographical references
520 $a Ultrasound has been developed as both a valuable diagnostic tool and a potent promoter of beneficial tissue bioeffects for the treatment of cardiovascular disease. Vascular effects can be mediated by mechanical oscillations of circulating microbubbles, or ultrasound contrast agents, which may also encapsulate and shield a therapeutic agent in the bloodstream. Oscillating microbubbles can create stresses directly on nearby tissue or induce fluid effects that effect drug penetration into vascular tissue, lyse thrombi, or direct drugs to optimal locations for delivery. These investigations have spurred continued research into alternative therapeutic applications, such as bioactive gas delivery. This dissertation addresses a fundamental hypothesis in biomedical ultrasound: ultrasound-mediated drug delivery is capable of increasing the penetration of drugs across different physiologic barriers within the cardiovascular system, such as the vascular endothelium, blood clots, and smooth muscle cells.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2023
538 $a Mode of access: World Wide Web
650 4 $a Biomedical engineering. $3 535387
650 4 $a Biophysics. $3 518360
650 4 $a Acoustics. $3 879105
653 $a Bioactive gas
653 $a Cavitation
653 $a Drug delivery
653 $a Ex vivo tissue
653 $a Sonothromboylsis
653 $a Ultrasound
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