東華大學圖書館 |

Conductive Hydrogels for Next-Generation Bio-Electronic Interfaces.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Conductive Hydrogels for Next-Generation Bio-Electronic Interfaces./
作者:	Feig, Vivian Rachel.
面頁冊數:	1 online resource (133 pages)
附註:	Source: Dissertations Abstracts International, Volume: 84-05, Section: B.
Contained By:	Dissertations Abstracts International84-05B.
標題:	Tissue engineering. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=29756272click for full text (PQDT)
ISBN:	9798357509369

Conductive Hydrogels for Next-Generation Bio-Electronic Interfaces.
Feig, Vivian Rachel.

Conductive Hydrogels for Next-Generation Bio-Electronic Interfaces. - 1 online resource (133 pages)

Source: Dissertations Abstracts International, Volume: 84-05, Section: B.

Thesis (Ph.D.)--Stanford University, 2020.

Includes bibliographical references

The bio-electronic interface is the next frontier of a wide range of biomedical therapies, from implanted devices that therapeutically stimulate organs, to regenerative medicines that use electrical cues to guide stem cell differentiation towards target lineages. Yet, severe mismatch in mechanical properties at this interface remains a major challenge. Conventional conductors are significantly more stiff (E~ GPa) than soft tissues (E~ kPa), which can lead to inflammatory encapsulation of implants and misdirection of differentiating cells. Moreover, conventional rigid conductors cannot accommodate the dynamic motions of bodily surfaces, hindering the effective transmission of electrical signals across the bio-electronic interface. Finally, in stark contrast to the 3D nature of cell-cell and cell-environment interactions, typical electronic interfaces are planar and 2D, which not only limits the potential density of bio-electronic interactions but can also negatively impact cell fate. This dissertation will describe the progress we have made towards designing next-generation conductive materials capable of possessing tissuelevel stiffness, high stretchability, and the capability to interface with biological targets in 3 dimensions.First, tissue-level stiffness is achieved by leveraging the ability of the conducting polymer PEDOT:PSS to form gel networks at remarkably low concentrations in water (1- 2 wt%). Ionic additives that induce PEDOT:PSS gelation are rationally selected to manipulate both electrical conductivity and gelation kinetics. We demonstrate that slow gelation enables molding of highly conductive hydrogels with ultra-low storage moduli (~100 Pa). We further demonstrate that mechanical properties like stretchability can be orthogonally introduced through the use of interpenetrating polymer networks. As a proof of concept, we interpenetrate PEDOT:PSS gels with different formulations of covalentlycrosslinked polyacrylic acid. The resulting conductive interpenetrating network (C-IPN) gels possess high conductivity (>10 S/m), high stretchability (up to 400%) and tunable elastic moduli over 3 biologically-relevant orders of magnitude (8-374 kPa) without compromising electrical performance.Second, we leverage the rapid gelation of PEDOT:PSS in the presence of metal cations to create a novel patterning method called electro-gelation patterning, in which electrochemical oxidation of a sacrificial metal thin film in the presence of aqueous PEDOT:PSS electrolyte enables high-resolution features and conformal surface coatings.Finally, 3D interfacing capability is achieved by using PEDOT:PSS hydrogels as microgel building blocks to form granular conductive hydrogels, which combine jamming-induced elasticity with excellent shear-thinning properties. We demonstrate that granular PEDOT:PSS gels can be mixed with cells to create conductive 3D cell scaffolds, which can further be deployed via minimally invasive injection methods. Taken together, our novel strategies for designing these conductors represent significant steps towards the development of therapeutics that can harness the full potential of electrical functionality in medicine.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2023

Mode of access: World Wide Web

ISBN: 9798357509369Subjects--Topical Terms:

823582
Tissue engineering.
Index Terms--Genre/Form:

542853
Electronic books.

Conductive Hydrogels for Next-Generation Bio-Electronic Interfaces.
LDR:04689nmm a2200481K 4500 001 2358917
005 20230830051519.5
006 m o d
007 cr mn ---uuuuu
008 241011s2020 xx obm 000 0 eng d
020 $a 9798357509369
035 $a (MiAaPQ)AAI29756272
035 $a (MiAaPQ)STANFORDwg477fd2488
035 $a AAI29756272
040 $a MiAaPQ $b eng $c MiAaPQ $d NTU
100 1 $a Feig, Vivian Rachel. $3 3699465
245 1 0 $a Conductive Hydrogels for Next-Generation Bio-Electronic Interfaces.
264 0 $c 2020
300 $a 1 online resource (133 pages)
336 $a text $b txt $2 rdacontent
337 $a computer $b c $2 rdamedia
338 $a online resource $b cr $2 rdacarrier
500 $a Source: Dissertations Abstracts International, Volume: 84-05, Section: B.
500 $a Advisor: Bao, Zhenan; Appel, Eric; Salleo, Alberto.
502 $a Thesis (Ph.D.)--Stanford University, 2020.
504 $a Includes bibliographical references
520 $a The bio-electronic interface is the next frontier of a wide range of biomedical therapies, from implanted devices that therapeutically stimulate organs, to regenerative medicines that use electrical cues to guide stem cell differentiation towards target lineages. Yet, severe mismatch in mechanical properties at this interface remains a major challenge. Conventional conductors are significantly more stiff (E~ GPa) than soft tissues (E~ kPa), which can lead to inflammatory encapsulation of implants and misdirection of differentiating cells. Moreover, conventional rigid conductors cannot accommodate the dynamic motions of bodily surfaces, hindering the effective transmission of electrical signals across the bio-electronic interface. Finally, in stark contrast to the 3D nature of cell-cell and cell-environment interactions, typical electronic interfaces are planar and 2D, which not only limits the potential density of bio-electronic interactions but can also negatively impact cell fate. This dissertation will describe the progress we have made towards designing next-generation conductive materials capable of possessing tissuelevel stiffness, high stretchability, and the capability to interface with biological targets in 3 dimensions.First, tissue-level stiffness is achieved by leveraging the ability of the conducting polymer PEDOT:PSS to form gel networks at remarkably low concentrations in water (1- 2 wt%). Ionic additives that induce PEDOT:PSS gelation are rationally selected to manipulate both electrical conductivity and gelation kinetics. We demonstrate that slow gelation enables molding of highly conductive hydrogels with ultra-low storage moduli (~100 Pa). We further demonstrate that mechanical properties like stretchability can be orthogonally introduced through the use of interpenetrating polymer networks. As a proof of concept, we interpenetrate PEDOT:PSS gels with different formulations of covalentlycrosslinked polyacrylic acid. The resulting conductive interpenetrating network (C-IPN) gels possess high conductivity (>10 S/m), high stretchability (up to 400%) and tunable elastic moduli over 3 biologically-relevant orders of magnitude (8-374 kPa) without compromising electrical performance.Second, we leverage the rapid gelation of PEDOT:PSS in the presence of metal cations to create a novel patterning method called electro-gelation patterning, in which electrochemical oxidation of a sacrificial metal thin film in the presence of aqueous PEDOT:PSS electrolyte enables high-resolution features and conformal surface coatings.Finally, 3D interfacing capability is achieved by using PEDOT:PSS hydrogels as microgel building blocks to form granular conductive hydrogels, which combine jamming-induced elasticity with excellent shear-thinning properties. We demonstrate that granular PEDOT:PSS gels can be mixed with cells to create conductive 3D cell scaffolds, which can further be deployed via minimally invasive injection methods. Taken together, our novel strategies for designing these conductors represent significant steps towards the development of therapeutics that can harness the full potential of electrical functionality in medicine.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2023
538 $a Mode of access: World Wide Web
650 4 $a Tissue engineering. $3 823582
650 4 $a Biocompatibility. $3 656157
650 4 $a Mechanical properties. $3 3549505
650 4 $a Polymers. $3 535398
650 4 $a Electrolytes. $3 656992
650 4 $a Transplants & implants. $3 3562683
650 4 $a Spectrum analysis. $3 520440
650 4 $a Additives. $3 3689237
650 4 $a Rheology. $3 570780
650 4 $a Brain research. $3 3561789
650 4 $a Electric fields. $3 880423
650 4 $a Microscopy. $3 540544
650 4 $a Medical research. $2 bicssc $3 1556686
650 4 $a Stainless steel. $3 3560388
650 4 $a Electronics. $3 517156
650 4 $a Thin films. $3 626403
650 4 $a Shear strain. $3 3681605
650 4 $a Morphology. $3 591167
650 4 $a Hydrogels. $3 1305894
650 4 $a Interfaces. $2 gtt $3 834756
650 4 $a Analytical chemistry. $3 3168300
650 4 $a Biology. $3 522710
650 4 $a Biomedical engineering. $3 535387
650 4 $a Chemistry. $3 516420
650 4 $a Condensed matter physics. $3 3173567
650 4 $a Electromagnetics. $3 3173223
650 4 $a Materials science. $3 543314
650 4 $a Mechanics. $3 525881
650 4 $a Neurosciences. $3 588700
650 4 $a Optics. $3 517925
650 4 $a Physics. $3 516296
650 4 $a Polymer chemistry. $3 3173488
650 4 $a Surgery. $3 707153
655 7 $a Electronic books. $2 lcsh $3 542853
690 $a 0287
690 $a 0486
690 $a 0306
690 $a 0541
690 $a 0485
690 $a 0611
690 $a 0607
690 $a 0794
690 $a 0346
690 $a 0317
690 $a 0752
690 $a 0605
690 $a 0495
690 $a 0576
710 2 $a ProQuest Information and Learning Co. $3 783688
710 2 $a Stanford University. $3 754827
773 0 $t Dissertations Abstracts International $g 84-05B.
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=29756272 $z click for full text (PQDT)