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In Vivo High-Speed Microscopy of Ultrasound-Stimulated Microbubble-Vessel Interactions.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	In Vivo High-Speed Microscopy of Ultrasound-Stimulated Microbubble-Vessel Interactions./
作者:	Anbarafshan, Rojin.
面頁冊數:	1 online resource (104 pages)
附註:	Source: Masters Abstracts International, Volume: 84-05.
Contained By:	Masters Abstracts International84-05.
標題:	Biophysics. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=29396217click for full text (PQDT)
ISBN:	9798357549051

In Vivo High-Speed Microscopy of Ultrasound-Stimulated Microbubble-Vessel Interactions.
Anbarafshan, Rojin.

In Vivo High-Speed Microscopy of Ultrasound-Stimulated Microbubble-Vessel Interactions. - 1 online resource (104 pages)

Source: Masters Abstracts International, Volume: 84-05.

Thesis (M.Sc.)--University of Toronto (Canada), 2022.

Includes bibliographical references

Ultrasound-stimulated microbubbles have emerged in a wide range of therapeutic applications, such as drug delivery, blood-brain barrier opening and tumor ablation. At sufficiently high pressures, microbubble cavitation becomes violent and induces sustained vascular damage. Despite extensive clinical potential, fundamental questions about microbubble-vessel interactions remain, particularly under longer pulse lengths and higher pressures typical of therapeutic exposures. Here we developed a novel system to enable simultaneous high-speed intravital imaging and cavitation monitoring of microbubbles in vivo in the chorioallantoic membrane of a duck embryo. We provide the first direct in vivo optical evidence of microbubble extravasation along with mechanical and acoustic insights into cavitation-induced microbubble-vessel interactions at spatiotemporal microscales. Results suggest that induced effects are highly dependent on vessel size, with smaller vessels being preferentially impacted. Overall, the outcomes of this study enhance our understanding of microbubble-induced vascular effects which is critical for safe and efficient development of ultrasound treatments.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2023

Mode of access: World Wide Web

ISBN: 9798357549051Subjects--Topical Terms:

518360
Biophysics.
Subjects--Index Terms:

CavitationIndex Terms--Genre/Form:

542853
Electronic books.

In Vivo High-Speed Microscopy of Ultrasound-Stimulated Microbubble-Vessel Interactions.
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500 $a Source: Masters Abstracts International, Volume: 84-05.
500 $a Advisor: Goertz, David.
502 $a Thesis (M.Sc.)--University of Toronto (Canada), 2022.
504 $a Includes bibliographical references
520 $a Ultrasound-stimulated microbubbles have emerged in a wide range of therapeutic applications, such as drug delivery, blood-brain barrier opening and tumor ablation. At sufficiently high pressures, microbubble cavitation becomes violent and induces sustained vascular damage. Despite extensive clinical potential, fundamental questions about microbubble-vessel interactions remain, particularly under longer pulse lengths and higher pressures typical of therapeutic exposures. Here we developed a novel system to enable simultaneous high-speed intravital imaging and cavitation monitoring of microbubbles in vivo in the chorioallantoic membrane of a duck embryo. We provide the first direct in vivo optical evidence of microbubble extravasation along with mechanical and acoustic insights into cavitation-induced microbubble-vessel interactions at spatiotemporal microscales. Results suggest that induced effects are highly dependent on vessel size, with smaller vessels being preferentially impacted. Overall, the outcomes of this study enhance our understanding of microbubble-induced vascular effects which is critical for safe and efficient development of ultrasound treatments.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2023
538 $a Mode of access: World Wide Web
650 4 $a Biophysics. $3 518360
650 4 $a Acoustics. $3 879105
650 4 $a Applied physics. $3 3343996
653 $a Cavitation
653 $a Contrast agent
653 $a In vivo
653 $a Microbubble
653 $a Ultrasound
653 $a Vascular effects
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773 0 $t Masters Abstracts International $g 84-05.
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