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Photoacoustic Fluctuation Sensing and Applications in Focusing Light through Scattering Media and Imaging.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Photoacoustic Fluctuation Sensing and Applications in Focusing Light through Scattering Media and Imaging./
作者:	Inzunza-Ibarra, Marco Antonio.
面頁冊數:	1 online resource (137 pages)
附註:	Source: Dissertations Abstracts International, Volume: 83-07, Section: B.
Contained By:	Dissertations Abstracts International83-07B.
標題:	Optics. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28861131click for full text (PQDT)
ISBN:	9798762106115

Photoacoustic Fluctuation Sensing and Applications in Focusing Light through Scattering Media and Imaging.
Inzunza-Ibarra, Marco Antonio.

Photoacoustic Fluctuation Sensing and Applications in Focusing Light through Scattering Media and Imaging. - 1 online resource (137 pages)

Source: Dissertations Abstracts International, Volume: 83-07, Section: B.

Thesis (Ph.D.)--University of Colorado at Boulder, 2021.

Includes bibliographical references

Photoacoustic imaging is based on the photoacoustic effect where ultrasound waves are generated by the transient absorption of light and subsequent thermo-elastic expansion. Photoacoustic imaging and sensing applications have grown significantly in recent years and here we present three novel biomedical applications that have contributed to the field. First, we report a photoacoustic guide star mechanism suitable for wavefront shaping through a scattering wall that is based on the fluctuations in the photoacoustic signals generated in a micro-vessel filled with flowing absorbers. The standard deviation of photoacoustic signals generated from random distributions of particles is dependent on the illumination volume and increases nonlinearly as the illumination volume is decreased. We harness this effect to guide wavefront shaping using the standard deviation of the photoacoustic response as the feedback signal. We further demonstrate sub-acoustic resolution optical focusing through a diffuser with a genetic algorithm optimization routine.Secondly, we report on the use of a novel photoacoustic technique to measure the impulse response of single microbubbles. Individual microbubbles are driven with a broadband photoacoustic wave generated by a nanosecond-pulse laser illuminating an optical absorber. The resulting microbubble oscillations were detected by following transmission of a second laser as it passes twice through the microbubble. The system could even resolve oscillations resulting from a single-shot. As a proof-of-concept study, the size-dependent, linear impulse response of lipid-coated microbubbles was characterized using this technique. This unique method of microbubble characterization with exceptional spatiotemporal resolution opens new avenues for capturing and analyzing microbubble system dynamics.Finally, a photoacoustic contrast mechanism is presented based on the photoacoustic fluctuations induced by microbubbles flowing inside a micro-vessel filled with a continuous absorber. It is demonstrated that the standard deviation of a homogeneous absorber mixed with microbubbles increases non-linearly as the microbubble concentration and microbubble size is increased. This effect is then utilized to perform photoacoustic fluctuation imaging resulting in increased visibility and contrast of a blood flow phantom.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2023

Mode of access: World Wide Web

ISBN: 9798762106115Subjects--Topical Terms:

517925
Optics.
Subjects--Index Terms:

FluctuationsIndex Terms--Genre/Form:

542853
Electronic books.

Photoacoustic Fluctuation Sensing and Applications in Focusing Light through Scattering Media and Imaging.
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520 $a Photoacoustic imaging is based on the photoacoustic effect where ultrasound waves are generated by the transient absorption of light and subsequent thermo-elastic expansion. Photoacoustic imaging and sensing applications have grown significantly in recent years and here we present three novel biomedical applications that have contributed to the field. First, we report a photoacoustic guide star mechanism suitable for wavefront shaping through a scattering wall that is based on the fluctuations in the photoacoustic signals generated in a micro-vessel filled with flowing absorbers. The standard deviation of photoacoustic signals generated from random distributions of particles is dependent on the illumination volume and increases nonlinearly as the illumination volume is decreased. We harness this effect to guide wavefront shaping using the standard deviation of the photoacoustic response as the feedback signal. We further demonstrate sub-acoustic resolution optical focusing through a diffuser with a genetic algorithm optimization routine.Secondly, we report on the use of a novel photoacoustic technique to measure the impulse response of single microbubbles. Individual microbubbles are driven with a broadband photoacoustic wave generated by a nanosecond-pulse laser illuminating an optical absorber. The resulting microbubble oscillations were detected by following transmission of a second laser as it passes twice through the microbubble. The system could even resolve oscillations resulting from a single-shot. As a proof-of-concept study, the size-dependent, linear impulse response of lipid-coated microbubbles was characterized using this technique. This unique method of microbubble characterization with exceptional spatiotemporal resolution opens new avenues for capturing and analyzing microbubble system dynamics.Finally, a photoacoustic contrast mechanism is presented based on the photoacoustic fluctuations induced by microbubbles flowing inside a micro-vessel filled with a continuous absorber. It is demonstrated that the standard deviation of a homogeneous absorber mixed with microbubbles increases non-linearly as the microbubble concentration and microbubble size is increased. This effect is then utilized to perform photoacoustic fluctuation imaging resulting in increased visibility and contrast of a blood flow phantom.
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