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Tissue-Mimicking Electronics : = Development of Miniaturized, Soft, Stretchable and Developmentally Morphing Bioelectronics.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Tissue-Mimicking Electronics :/
其他題名:	Development of Miniaturized, Soft, Stretchable and Developmentally Morphing Bioelectronics.
作者:	Liu, Yuxin.
面頁冊數:	1 online resource (185 pages)
附註:	Source: Dissertations Abstracts International, Volume: 83-05, Section: B.
Contained By:	Dissertations Abstracts International83-05B.
標題:	Biocompatibility. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28827930click for full text (PQDT)
ISBN:	9798494461537

Tissue-Mimicking Electronics : = Development of Miniaturized, Soft, Stretchable and Developmentally Morphing Bioelectronics.
Liu, Yuxin.

Tissue-Mimicking Electronics :Development of Miniaturized, Soft, Stretchable and Developmentally Morphing Bioelectronics. - 1 online resource (185 pages)

Source: Dissertations Abstracts International, Volume: 83-05, Section: B.

Thesis (Ph.D.)--Stanford University, 2019.

Includes bibliographical references

Implantable devices, such as the vagus nerve stimulator (VNS) and the implantable cardioverter defibrillator (ICD), have been widely used to treat cardiac and neurological diseases. However, they are made of rigid electronic materials. The significant mechanical mismatch between stiff electronics and soft biological tissues causes negative immunoresponses, tissue damage, and device dislocation. To address those problems, we developed soft and electronically active materials with tissue-like Young's modulus and microfabrication methods for stretchable microelectronics. We demonstrated intimate electrical coupling with neural tissues and localized ultralow-voltage electrical stimulation on the peripheral nerves in vivo. To accommodate organ dynamics, such as the beating of the heart, we fabricated a fully elastic microelectrode array for stable electrophysiological recording without electrode displacement during cardiac contraction-relaxation cycles. Epicardial electrophysiological mapping on a chronic atrial fibrillation porcine model showed excellent signal-to-noise ratio and significantly higher spatial resolution compared with the state-of-the-art cardiac mapping system. Finally, we developed an implantable device that can accommodate rapid tissue growth without negatively influencing normal developmental functions. Current implantable bioelectronic devices mechanically constrain the growing tissue due to their fixed shapes and sizes. For infants, children, and adolescents, once implanted devices are 'outgrown', additional surgeries are usually needed for device removal, followed by replacement. These tedious processes inevitably lead to repeated intervention and elevated complication rates. We addressed this limitation by developing Morphing Electronics (termed MorphE), which are designed and fabricated to suitably adapt to in vivo tissue growth with minimal mechanical constraint. Animal studies showed that the soft and self-adapting MorphE caused no damage to a rat nerve after it had grown to 2.4 times its initial diameter. The stable neural interface allowed chronic electrical stimulation and monitoring without disruption of functional behavior in developing animals. As such, MorphE creates a new avenue for adaptive pediatric electronics medicine.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2023

Mode of access: World Wide Web

ISBN: 9798494461537Subjects--Topical Terms:

656157
Biocompatibility.
Index Terms--Genre/Form:

542853
Electronic books.

Tissue-Mimicking Electronics : = Development of Miniaturized, Soft, Stretchable and Developmentally Morphing Bioelectronics.
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500 $a Source: Dissertations Abstracts International, Volume: 83-05, Section: B.
500 $a Advisor: Bao, Zhenan; Cui, Bianxiao; George, Paul; Yock, Paul.
502 $a Thesis (Ph.D.)--Stanford University, 2019.
504 $a Includes bibliographical references
520 $a Implantable devices, such as the vagus nerve stimulator (VNS) and the implantable cardioverter defibrillator (ICD), have been widely used to treat cardiac and neurological diseases. However, they are made of rigid electronic materials. The significant mechanical mismatch between stiff electronics and soft biological tissues causes negative immunoresponses, tissue damage, and device dislocation. To address those problems, we developed soft and electronically active materials with tissue-like Young's modulus and microfabrication methods for stretchable microelectronics. We demonstrated intimate electrical coupling with neural tissues and localized ultralow-voltage electrical stimulation on the peripheral nerves in vivo. To accommodate organ dynamics, such as the beating of the heart, we fabricated a fully elastic microelectrode array for stable electrophysiological recording without electrode displacement during cardiac contraction-relaxation cycles. Epicardial electrophysiological mapping on a chronic atrial fibrillation porcine model showed excellent signal-to-noise ratio and significantly higher spatial resolution compared with the state-of-the-art cardiac mapping system. Finally, we developed an implantable device that can accommodate rapid tissue growth without negatively influencing normal developmental functions. Current implantable bioelectronic devices mechanically constrain the growing tissue due to their fixed shapes and sizes. For infants, children, and adolescents, once implanted devices are 'outgrown', additional surgeries are usually needed for device removal, followed by replacement. These tedious processes inevitably lead to repeated intervention and elevated complication rates. We addressed this limitation by developing Morphing Electronics (termed MorphE), which are designed and fabricated to suitably adapt to in vivo tissue growth with minimal mechanical constraint. Animal studies showed that the soft and self-adapting MorphE caused no damage to a rat nerve after it had grown to 2.4 times its initial diameter. The stable neural interface allowed chronic electrical stimulation and monitoring without disruption of functional behavior in developing animals. As such, MorphE creates a new avenue for adaptive pediatric electronics medicine.
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