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Enabling Skeletal Muscle Repair and Functional Recovery Following Denervation-Induced Injury Using Ultrasound Mediated Gene Delivery (UMGD).

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Enabling Skeletal Muscle Repair and Functional Recovery Following Denervation-Induced Injury Using Ultrasound Mediated Gene Delivery (UMGD)./
作者:	Te, Lucas Jaryd.
面頁冊數:	1 online resource (196 pages)
附註:	Source: Masters Abstracts International, Volume: 83-01.
Contained By:	Masters Abstracts International83-01.
標題:	Biology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28263162click for full text (PQDT)
ISBN:	9798522942939

Enabling Skeletal Muscle Repair and Functional Recovery Following Denervation-Induced Injury Using Ultrasound Mediated Gene Delivery (UMGD).
Te, Lucas Jaryd.

Enabling Skeletal Muscle Repair and Functional Recovery Following Denervation-Induced Injury Using Ultrasound Mediated Gene Delivery (UMGD). - 1 online resource (196 pages)

Source: Masters Abstracts International, Volume: 83-01.

Thesis (M.Sc.)--University of Toronto (Canada), 2021.

Includes bibliographical references

Skeletal muscle is essential for mobility and its health relies upon innervation. Peripheral nerve injury denervates target skeletal muscle, causing immediate loss of function, atrophy, and development of fibrosis. Delayed re-innervation can result in permanent functional loss, leading to a myriad of physical, financial, social, and psychological burdens on affected individuals. Ultrasound-mediated Gene Delivery (UMGD) is a relatively novel technique that has been shown to provide localized and effective gene therapy in vivo. We hypothesize that UMGD of myogenic genes IGF-1, VEGF, and Ang-1 would sustain the mass and regenerative potential of denervated muscle awaiting reinnervation. After two weeks, UMGD of these genes mildly increased gross muscle weight, Type II fibre CSA, and vascularization compared to denervated muscle given no transgene. We have shown that UMGD is a viable model for targeted gene delivery to skeletal muscle through partial prevention of the atrophy and vascular loss induced by denervation injury.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2023

Mode of access: World Wide Web

ISBN: 9798522942939Subjects--Topical Terms:

522710
Biology.
Subjects--Index Terms:

DenervationIndex Terms--Genre/Form:

542853
Electronic books.

Enabling Skeletal Muscle Repair and Functional Recovery Following Denervation-Induced Injury Using Ultrasound Mediated Gene Delivery (UMGD).
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502 $a Thesis (M.Sc.)--University of Toronto (Canada), 2021.
504 $a Includes bibliographical references
520 $a Skeletal muscle is essential for mobility and its health relies upon innervation. Peripheral nerve injury denervates target skeletal muscle, causing immediate loss of function, atrophy, and development of fibrosis. Delayed re-innervation can result in permanent functional loss, leading to a myriad of physical, financial, social, and psychological burdens on affected individuals. Ultrasound-mediated Gene Delivery (UMGD) is a relatively novel technique that has been shown to provide localized and effective gene therapy in vivo. We hypothesize that UMGD of myogenic genes IGF-1, VEGF, and Ang-1 would sustain the mass and regenerative potential of denervated muscle awaiting reinnervation. After two weeks, UMGD of these genes mildly increased gross muscle weight, Type II fibre CSA, and vascularization compared to denervated muscle given no transgene. We have shown that UMGD is a viable model for targeted gene delivery to skeletal muscle through partial prevention of the atrophy and vascular loss induced by denervation injury.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2023
538 $a Mode of access: World Wide Web
650 4 $a Biology. $3 522710
650 4 $a Cellular biology. $3 3172791
650 4 $a Physiology. $3 518431
650 4 $a Vascular endothelial growth factor. $3 3560851
650 4 $a Blood vessels. $3 3561732
650 4 $a Identification. $3 827285
650 4 $a Extracellular matrix. $3 684719
650 4 $a Flow cytometry. $3 600581
650 4 $a Metabolism. $3 541349
650 4 $a Pathology. $3 643180
650 4 $a Brain-derived neurotrophic factor. $3 3685829
650 4 $a Apoptosis. $3 600650
650 4 $a Respiration. $3 610890
650 4 $a Kinases. $3 3558077
650 4 $a Angiogenesis. $3 3561733
650 4 $a Proteins. $3 558769
650 4 $a Plasmids. $3 3319070
650 4 $a Homeostasis. $3 657244
650 4 $a Regulation. $3 3561775
650 4 $a Fibroblasts. $3 1573241
650 4 $a Collagen. $3 892448
650 4 $a Hypotheses. $3 3560118
650 4 $a Musculoskeletal system. $3 548825
650 4 $a Experiments. $3 525909
650 4 $a Literature reviews. $3 3559998
650 4 $a Insulin-like growth factors. $3 3561784
650 4 $a Ultrasonic imaging. $3 828386
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653 $a FAPs
653 $a Gene therapy
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653 $a Ultrasound
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