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Genetic and Environmental Determinants of Late-Life Cognitive Function over the Life Course.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Genetic and Environmental Determinants of Late-Life Cognitive Function over the Life Course./
作者:	Vasiljevic, Eva.
面頁冊數:	1 online resource (143 pages)
附註:	Source: Dissertations Abstracts International, Volume: 84-06, Section: B.
Contained By:	Dissertations Abstracts International84-06B.
標題:	Epidemiology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30242969click for full text (PQDT)
ISBN:	9798358498983

Genetic and Environmental Determinants of Late-Life Cognitive Function over the Life Course.
Vasiljevic, Eva.

Genetic and Environmental Determinants of Late-Life Cognitive Function over the Life Course. - 1 online resource (143 pages)

Source: Dissertations Abstracts International, Volume: 84-06, Section: B.

Thesis (Ph.D.)--The University of Wisconsin - Madison, 2022.

Includes bibliographical references

Chronic diseases are caused by a mixture of biological, behavioral, environmental, social, and structural factors that operate on both a short- and long-term time scale over a person's life, and even over generations. This work focuses on genetic and environmental influences over the life course on late-life cognitive function. Cognitive function is a defining factor of dementia, a chronic disease, and dementia subtypes like Alzheimer's disease (AD) clinical syndrome. Understanding both what affects changes in late-life cognitive function and the timeline which risk factors operate on is critical to eventually characterize when and what interventions would have the biggest effect on improving cognitive function in late-life. This work takes a preliminary step in that direction. First, it evaluates how cognitive trajectories differ across AD genetic risk groups and when differences in those trajectories can be identified. Second, it evaluates the effect of thein utero nutritional environment on late-life cognitive function and if that environment can modify genetic risk of decreased cognitive function. Third, it evaluates how mid- and late-life neighborhood environment can modify the effect of genetic risk on late-life cognitive function. All three project components use longitudinal data and mixed effects regression analysis to answer these research questions. This work finds that cognitive trajectories do differ by AD genetic risk groups and those differences can be detected at approximately age 65. It also finds that thein utero nutritional environment does affect late-life cognition and does modify the effects of AD genetic risk on cognitive function. Results were null regarding whether the mid- and late-life neighborhood environment can modify AD genetic risk on late-life cognitive function. Overall, the project indicates there are influences over the life-course on late-life cognition as early as thein utero period. In addition, some risk factors do not act in isolation but interact with each other to affect cognitive function.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2023

Mode of access: World Wide Web

ISBN: 9798358498983Subjects--Topical Terms:

568544
Epidemiology.
Subjects--Index Terms:

AgingIndex Terms--Genre/Form:

542853
Electronic books.

Genetic and Environmental Determinants of Late-Life Cognitive Function over the Life Course.
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