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Developing and Characterizing a Novel Tempo CNF Hydrogel Adjuvant and Delivery System for Aquatic Vaccines.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Developing and Characterizing a Novel Tempo CNF Hydrogel Adjuvant and Delivery System for Aquatic Vaccines./
作者:	Kukk, Kora.
面頁冊數:	1 online resource (131 pages)
附註:	Source: Masters Abstracts International, Volume: 84-06.
Contained By:	Masters Abstracts International84-06.
標題:	Biocompatibility. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30195056click for full text (PQDT)
ISBN:	9798358407688

Developing and Characterizing a Novel Tempo CNF Hydrogel Adjuvant and Delivery System for Aquatic Vaccines.
Kukk, Kora.

Developing and Characterizing a Novel Tempo CNF Hydrogel Adjuvant and Delivery System for Aquatic Vaccines. - 1 online resource (131 pages)

Source: Masters Abstracts International, Volume: 84-06.

Thesis (M.Sc.)--The University of Maine, 2022.

Includes bibliographical references

Aquaculture is a large part of the food production sector which is greatly expanding. One of the largest losses in aquaculture is due to pathogens. Current solutions for protecting farmed finfish from pathogens can be very expensive with variable efficiency. Current disease prevention strategies include vaccination. Types of vaccines include immersion vaccines, feed vaccines, and injectable vaccines. The most popular solution is oil-based injectable vaccines due to its protection. However, the oil-based adjuvant used in most of these formulations causes adverse reactions in the fish including reduced growth. These vaccines require multiple administrations throughout the fish's lifetime causing unwanted handling stress and additional labor costs. Preliminary trials show that cellulose nanomaterials cause minimal adverse reactions when injected into salmon and does not significantly affect their growth. The goal of this research was to create an adjuvant from cellulose nanomaterials which would increase bacterin efficacy while avoiding harmful side effects. A prolonged release formulation was also desirable, obviating the need for multiple vaccinations. Additionally, hydrogels have been used for a wide variety of applications including drug delivery, making them an attractive aquatic vaccine adjuvant. Cellulose nanomaterials were decided as the polymer to make up the hydrogel matrix due to their biocompatibility, sustainability, high tunability, high abundance, low cost. The development of the hydrogel formulation, modifying the hydrogel for easier delivery into the salmon, measuring the diffusive properties of the hydrogel, and in vivo testing of the hydrogel for analysis of delivery methods and reactions to the formulation are described in this research.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2023

Mode of access: World Wide Web

ISBN: 9798358407688Subjects--Topical Terms:

656157
Biocompatibility.
Index Terms--Genre/Form:

542853
Electronic books.

Developing and Characterizing a Novel Tempo CNF Hydrogel Adjuvant and Delivery System for Aquatic Vaccines.
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500 $a Source: Masters Abstracts International, Volume: 84-06.
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502 $a Thesis (M.Sc.)--The University of Maine, 2022.
504 $a Includes bibliographical references
520 $a Aquaculture is a large part of the food production sector which is greatly expanding. One of the largest losses in aquaculture is due to pathogens. Current solutions for protecting farmed finfish from pathogens can be very expensive with variable efficiency. Current disease prevention strategies include vaccination. Types of vaccines include immersion vaccines, feed vaccines, and injectable vaccines. The most popular solution is oil-based injectable vaccines due to its protection. However, the oil-based adjuvant used in most of these formulations causes adverse reactions in the fish including reduced growth. These vaccines require multiple administrations throughout the fish's lifetime causing unwanted handling stress and additional labor costs. Preliminary trials show that cellulose nanomaterials cause minimal adverse reactions when injected into salmon and does not significantly affect their growth. The goal of this research was to create an adjuvant from cellulose nanomaterials which would increase bacterin efficacy while avoiding harmful side effects. A prolonged release formulation was also desirable, obviating the need for multiple vaccinations. Additionally, hydrogels have been used for a wide variety of applications including drug delivery, making them an attractive aquatic vaccine adjuvant. Cellulose nanomaterials were decided as the polymer to make up the hydrogel matrix due to their biocompatibility, sustainability, high tunability, high abundance, low cost. The development of the hydrogel formulation, modifying the hydrogel for easier delivery into the salmon, measuring the diffusive properties of the hydrogel, and in vivo testing of the hydrogel for analysis of delivery methods and reactions to the formulation are described in this research.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2023
538 $a Mode of access: World Wide Web
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650 4 $a Vaccines. $3 684854
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650 4 $a Fish hatcheries. $3 2003221
650 4 $a Antibiotics. $3 670318
650 4 $a Deoxyribonucleic acid--DNA. $3 3546879
650 4 $a Design. $3 518875
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650 4 $a Salinity. $3 594109
650 4 $a Hydrogels. $3 1305894
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650 4 $a Aquatic sciences. $3 3174300
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773 0 $t Masters Abstracts International $g 84-06.
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30195056 $z click for full text (PQDT)