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Engineering Designer Biomaterials from Topologically Diverse Polyacrylamide Derivatives.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Engineering Designer Biomaterials from Topologically Diverse Polyacrylamide Derivatives./
作者:	Mann, Joseph Louis.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2021,
面頁冊數:	210 p.
附註:	Source: Dissertations Abstracts International, Volume: 83-05, Section: B.
Contained By:	Dissertations Abstracts International83-05B.
標題:	Polymers. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28812895
ISBN:	9798494455093

Engineering Designer Biomaterials from Topologically Diverse Polyacrylamide Derivatives.
Mann, Joseph Louis.

Engineering Designer Biomaterials from Topologically Diverse Polyacrylamide Derivatives. - Ann Arbor : ProQuest Dissertations & Theses, 2021 - 210 p.

Source: Dissertations Abstracts International, Volume: 83-05, Section: B.

Thesis (Ph.D.)--Stanford University, 2021.

This item must not be sold to any third party vendors.

The translational pharmaceutical landscape is rapidly changing and demands new polymers for both drug stability and delivery. Polyacrylamide derivatives have demonstrated a lack of immunogenicity, water solubility, chemical stability, and are both commercially available and inexpensive, making them attractive candidates for translational use. Moreover, polyacrylamides with the chemical, size, and topological control needed for translation can be synthesized via reverse addition fragmentation transfer (RAFT) polymerization, a scalable, robust, and coming-off-patent polymerization technique. This research in this dissertation highlights the promise of polyacrylamide derivatives, synthesized via RAFT, as translational biomaterials. The first portion of this dissertation will describe new developments in insulin formulation technology. I propose the use of polyacrylamide amphiphilic carrier/dopant copolymers (AC/DC) as novel excipients to occupy the air-water interface I will cover the synthesis of a library of AC/DC excipients, the proposed mechanism of action, and formulation work to generate both the (1) fastest acting, stable, injectable insulin formulation and (2) a commercial cold chain resilient insulin formulation. The second portion of the dissertation will describe a new adjuvant platform for subunit vaccines enabled by a hyperbranched polyacrylamide derivative. I will (1) highlight a universal scaling behavior uncovered during the synthesis of these materials, (2) a processing step to generate low-dispersity hyperbranched polymers, and (3) the implementation of adjuvant-conjugated hyperbranched polymers as adjuvants for vaccines. In summary, in this dissertation I will explain how novel polyacrylamide derivative biomaterials can be used to address the need of rapidly changing pharmaceutical landscape.

ISBN: 9798494455093Subjects--Topical Terms:

535398
Polymers.

Engineering Designer Biomaterials from Topologically Diverse Polyacrylamide Derivatives.
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520 $a The translational pharmaceutical landscape is rapidly changing and demands new polymers for both drug stability and delivery. Polyacrylamide derivatives have demonstrated a lack of immunogenicity, water solubility, chemical stability, and are both commercially available and inexpensive, making them attractive candidates for translational use. Moreover, polyacrylamides with the chemical, size, and topological control needed for translation can be synthesized via reverse addition fragmentation transfer (RAFT) polymerization, a scalable, robust, and coming-off-patent polymerization technique. This research in this dissertation highlights the promise of polyacrylamide derivatives, synthesized via RAFT, as translational biomaterials. The first portion of this dissertation will describe new developments in insulin formulation technology. I propose the use of polyacrylamide amphiphilic carrier/dopant copolymers (AC/DC) as novel excipients to occupy the air-water interface I will cover the synthesis of a library of AC/DC excipients, the proposed mechanism of action, and formulation work to generate both the (1) fastest acting, stable, injectable insulin formulation and (2) a commercial cold chain resilient insulin formulation. The second portion of the dissertation will describe a new adjuvant platform for subunit vaccines enabled by a hyperbranched polyacrylamide derivative. I will (1) highlight a universal scaling behavior uncovered during the synthesis of these materials, (2) a processing step to generate low-dispersity hyperbranched polymers, and (3) the implementation of adjuvant-conjugated hyperbranched polymers as adjuvants for vaccines. In summary, in this dissertation I will explain how novel polyacrylamide derivative biomaterials can be used to address the need of rapidly changing pharmaceutical landscape.
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