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Studies on Non-Digestible Carbohydrates in the Human Intestine: Focus on Kinetics of Fermentation and Degradation.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Studies on Non-Digestible Carbohydrates in the Human Intestine: Focus on Kinetics of Fermentation and Degradation./
作者:	van Trijp, Mara P. H.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2022,
面頁冊數:	319 p.
附註:	Source: Dissertations Abstracts International, Volume: 83-09, Section: B.
Contained By:	Dissertations Abstracts International83-09B.
標題:	Fermentation. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=29110707
ISBN:	9798209901242

Studies on Non-Digestible Carbohydrates in the Human Intestine: Focus on Kinetics of Fermentation and Degradation.
van Trijp, Mara P. H.

Studies on Non-Digestible Carbohydrates in the Human Intestine: Focus on Kinetics of Fermentation and Degradation. - Ann Arbor : ProQuest Dissertations & Theses, 2022 - 319 p.

Source: Dissertations Abstracts International, Volume: 83-09, Section: B.

Thesis (Ph.D.)--Wageningen University and Research, 2022.

This item must not be sold to any third party vendors.

Digestible and non-digestible carbohydrates are present in food. The non-digestible carbohydrates (NDCs), or dietary fiber, are natural components of plant food sources such as fruits, vegetables, nuts, legumes, and grains. Increased consumption of NDCs has been linked to numerous health benefits such as a reduced risk of obesity or intestinal disease and improved intestinal function. Unlike digestible carbohydrates, which are absorbed into the body and used as an energy source, NDCs are not broken down by host enzymes. However, certain NDCs can be broken down by intestinal bacteria. This process, which is called fermentation, results in a change in the composition of the bacteria and in the production of bacterial metabolites. These are in particular the shortchain fatty acids (SCFA) with acetate, propionate, and butyrate as the main end products. The SCFAs are an important energy source for the intestinal cells, and butyrate acid may reduce intestinal inflammation. It has previously been shown in mice that increased uptake of SCFAs from the large intestine is associated with improvements in metabolic health markers in the blood, such as glucose and insulin levels. Because the composition of the intestinal microbiota, including the bacteria, in the small and large intestine plays an important role in health, modulating this composition through changes in diet can be a strategy to improve health status. Prebiotic NDCs, including galacto-oligosaccharides (GOS), fructo-oligosaccharides (FOS), and inulin, can selectively stimulate the growth and/or activity of specific intestinal bacteria linked to health benefits. For this reason, prebiotics are isolated from the original plant material and are used as ingredients in certain food products. However, detailed knowledge on NDC degradation profiles, metabolites produced, and microbiota shifts generated by NDC in the human intestine is lacking. This information will facilitate the prediction of potential beneficial health consequences of NDC consumption. The work in this thesis describes the breakdown and fermentation of specific NDCs, including prebiotics, in the human intestine. We also investigated the effects of short- and longer-term interventions varying in NDC composition on the intestine, including changes in microbiota, and their relationship to metabolic processes.

ISBN: 9798209901242Subjects--Topical Terms:

658044
Fermentation.

Studies on Non-Digestible Carbohydrates in the Human Intestine: Focus on Kinetics of Fermentation and Degradation.
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