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White Matter Alterations Associated with Aging: Applications for Early Brain Development and Alzheimer's Disease Dementia.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	White Matter Alterations Associated with Aging: Applications for Early Brain Development and Alzheimer's Disease Dementia./
作者:	Moody, Jason F.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2022,
面頁冊數:	201 p.
附註:	Source: Dissertations Abstracts International, Volume: 84-01, Section: B.
Contained By:	Dissertations Abstracts International84-01B.
標題:	Medical imaging. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=29255787
ISBN:	9798834033493

White Matter Alterations Associated with Aging: Applications for Early Brain Development and Alzheimer's Disease Dementia.
Moody, Jason F.

White Matter Alterations Associated with Aging: Applications for Early Brain Development and Alzheimer's Disease Dementia. - Ann Arbor : ProQuest Dissertations & Theses, 2022 - 201 p.

Source: Dissertations Abstracts International, Volume: 84-01, Section: B.

Thesis (Ph.D.)--The University of Wisconsin - Madison, 2022.

This item must not be sold to any third party vendors.

White Matter (WM) plays a crucial role in healthy brain development and function, andcorrespondingly, is affected in a myriad of neurological pathologies. For example, early-lifealterations in WM have been implicated in numerous neurodevelopmental and psychiatricdisorders, including autism, cerebral palsy, ADHD, schizophrenia, bipolar disorder, and anxiety,leading to a recent emphasis on the role of WM development in the manifestation of thesedisorders. Additionally, the degeneration of WM pathways is a hallmark of cognitive decline anddementia in aging adults, with growing evidence suggesting that WM degeneration is a criticalcomponent of early Alzheimer's disease (AD) pathophysiology. This body of work utilizes variousquantitative magnetic resonance imaging (MRI) techniques, including diffusion tensor imaging(DTI), neurite orientation dispersion and density imaging (NODDI), mean apparent propagatorMRI (MAP-MRI), and quantitative R1 (qR1) relaxometry, to characterize age-related WM changesin vivo, in human and nonhuman primate populations at opposite ends of the lifespan. This isachieved by an exhaustive analysis of the spatiotemporal dynamics of WM microstructuralproperties in two cohorts: 1) A group of 35 infant rhesus macaques scanned at five timepointsthroughout the first year of life and 2) A group of hundreds of aging adults, including some alongthe biological and clinical AD continuum. By examining age-related changes in WM microstructureacross primate species, age range, sex, clinical diagnoses, and in vivo biomarkers of ADpathology and AD-related neurodegeneration, we provide insights into some of the factors thatinfluence age-related alterations in WM. Our work lays the foundation for future investigations intothe cellular, molecular, and physiological mechanisms that underly age-related WM changes andcontributes to a growing body of literature that may ultimately improve our understanding,detection, and treatment of neurodevelopmental, psychiatric, and neurodegenerative disorders.

ISBN: 9798834033493Subjects--Topical Terms:

3172799
Medical imaging.
Subjects--Index Terms:

Aging

White Matter Alterations Associated with Aging: Applications for Early Brain Development and Alzheimer's Disease Dementia.
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