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The Molecular Basis of Neural Wiring Specificity.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	The Molecular Basis of Neural Wiring Specificity./
作者:	Xie, Qijing.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2022,
面頁冊數:	134 p.
附註:	Source: Dissertations Abstracts International, Volume: 84-01, Section: B.
Contained By:	Dissertations Abstracts International84-01B.
標題:	CRISPR. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=29176546
ISBN:	9798835540525

The Molecular Basis of Neural Wiring Specificity.
Xie, Qijing.

The Molecular Basis of Neural Wiring Specificity. - Ann Arbor : ProQuest Dissertations & Theses, 2022 - 134 p.

Source: Dissertations Abstracts International, Volume: 84-01, Section: B.

Thesis (Ph.D.)--Stanford University, 2022.

This item must not be sold to any third party vendors.

The nervous system is incredibly complex. An adult human brain consists of about 86 billion neurons forming ~10.

ISBN: 9798835540525Subjects--Topical Terms:

3561750
CRISPR.

The Molecular Basis of Neural Wiring Specificity.
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245 1 4 $a The Molecular Basis of Neural Wiring Specificity.
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300 $a 134 p.
500 $a Source: Dissertations Abstracts International, Volume: 84-01, Section: B.
500 $a Advisor: Luo, Liqun;Clandinin, Thomas;Kaltschmidt, Julia;Shen, Kang.
502 $a Thesis (Ph.D.)--Stanford University, 2022.
506 $a This item must not be sold to any third party vendors.
520 $a The nervous system is incredibly complex. An adult human brain consists of about 86 billion neurons forming ~10.
520 $a 14 connections. Even in simpler organisms such as the fruit fly, there are around 200,000 neurons in its brain forming ~10.
520 $a 7 connections. Precise formation of these neuronal connections ensures proper information processing, which underlies all nervous system functions. Errors made during the formation of these neuronal connections can lead to neurodevelopmental disorders, such as intellectual disability and autism spectrum disorders. Therefore, it is critical to understand the molecular basis of neural wiring specificity.In this dissertation, I used the Drosophila olfactory circuit as a model to study molecules and transcriptional programs that underlie the precise formation of neural circuits. This circuit is an excellent model for studying neural wiring specificity because of its stereotypic and genetically encoded neuronal connection: ~50 types of olfactory receptor neurons (ORNs) form precise one-to-one synaptic connections with ~50 types of corresponding projection neurons (PNs) in ~50 glomerular compartments in the antennal lobe.First, I report that Fish-lips, a transmembrane protein, mediates repulsion between non-synaptic partner ORN axons and PN dendrites to prevent misconnections (Chapter 2). Second, I describe the single-cell transcriptomes of PNs at different developmental stages, which reveal distinct transcriptomic programs unfolding at each stage (Chapter 3). Lastly, I show how a single transcription factor, Acj6, controls wiring specificity in different neuron types by specifying distinct combinatorial expression of cell-surface proteins (Chapter 4).
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