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Metagenomics-Enabled Viral Ecology to Advance Our Understanding of Human and Environmental Microbiomes.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Metagenomics-Enabled Viral Ecology to Advance Our Understanding of Human and Environmental Microbiomes./
作者:	Kieft, Kristopher.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2022,
面頁冊數:	254 p.
附註:	Source: Dissertations Abstracts International, Volume: 83-12, Section: B.
Contained By:	Dissertations Abstracts International83-12B.
標題:	Bioinformatics. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=29252476
ISBN:	9798819383704

Metagenomics-Enabled Viral Ecology to Advance Our Understanding of Human and Environmental Microbiomes.
Kieft, Kristopher.

Metagenomics-Enabled Viral Ecology to Advance Our Understanding of Human and Environmental Microbiomes. - Ann Arbor : ProQuest Dissertations & Theses, 2022 - 254 p.

Source: Dissertations Abstracts International, Volume: 83-12, Section: B.

Thesis (Ph.D.)--The University of Wisconsin - Madison, 2022.

This item must not be sold to any third party vendors.

Viruses are omnipresent and influence life processes on micro and macro scales. All viruses require a host cell to replicate, which they accomplish by hijacking the host cells' machinery and resources. Due to this, viruses, especially those that infect microorganisms, are keystone controllers of nutrient and biomass recycling, ecosystem-wide biogeochemical cycling, host population abundances, community interactions, evolutionary momentum, and more. Understanding viruses is critical to the advancement of diverse fields such as agriculture, medicine, industry, ecosystem science, oceanography, and biogeochemistry. Despite their importance, viruses remain difficult to study as they cannot be easily cultivated in a laboratory. Cultivation independent approaches such as metagenomics and viromics can enable the study of uncultivated viruses directly from the environment, though there is a lack of accurate bioinformatics tools to analyze viruses from metagenomes.I am interested in exploring the ecology, evolution, and diversity of viruses in nature and investigating their impacts on global biogeochemical cycles. My dissertation is categorized into two main Aims. Aim one of my research is to use systems biology approaches to expand our understanding of viruses by quantifying their impacts on microorganisms and ecosystems. I will specifically focus on viral encoded genes for assimilatory (Chapter 2) and dissimilatory (Chapter 3) sulfur metabolism. Aim two of my dissertation research is to develop novel bioinformatics tools for the study of viruses in metagenomes and viromes. These approaches will serve as the foundation of next generation virology and studying how viruses fit within microbial communities and global biogeochemical cycles by identifying viral genomes (Chapter 4), deciphering active viruses from DNA sequences (Chapter 5), and constructing viral genomes from mixed communities (Chapter 6). Finally, I provide my observations on where the field of viral genomics stands, established conventions that would benefit from change, and future prospects of the field as a whole (Chapter 7).

ISBN: 9798819383704Subjects--Topical Terms:

553671
Bioinformatics.
Subjects--Index Terms:

Biogeochemistry

Metagenomics-Enabled Viral Ecology to Advance Our Understanding of Human and Environmental Microbiomes.
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