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Nonlinear Nanobubble Behaviour for Vascular and Extravascular Applications.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Nonlinear Nanobubble Behaviour for Vascular and Extravascular Applications./
作者:	Pellow, Carly Tara.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2021,
面頁冊數:	251 p.
附註:	Source: Dissertations Abstracts International, Volume: 83-01, Section: B.
Contained By:	Dissertations Abstracts International83-01B.
標題:	Biophysics. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28322827
ISBN:	9798522944575

Nonlinear Nanobubble Behaviour for Vascular and Extravascular Applications.
Pellow, Carly Tara.

Nonlinear Nanobubble Behaviour for Vascular and Extravascular Applications. - Ann Arbor : ProQuest Dissertations & Theses, 2021 - 251 p.

Source: Dissertations Abstracts International, Volume: 83-01, Section: B.

Thesis (Ph.D.)--University of Toronto (Canada), 2021.

This item must not be sold to any third party vendors.

Nanomedicines exhibit novel properties with structural versatility, improved pharmacokinetic profiles, and multifunctionality for advanced delivery strategies targeting infiltrative tumours while sparing surrounding normal tissue. Consolidating the abilities of traditional nanoparticles with conventional ultrasound agents by shrinking microbubbles to the nanoscale can have profound effects on bubble behaviour, bringing new possibilities as well as challenges. This dissertation aims to address current limitations of nanobubbles, laying the groundwork for their utility within and beyond the vasculature.Insights on nanobubble behaviour in vessel- and tissue-mimicking surroundings through theoretical and experimental approaches are presented. The first observation that nanobubbles can initiate sustained pressure threshold-dependent nonlinear scattering is shown, and found to be highly sensitive to nonlinear shell rheology.Novel direct acoustic evidence that nanobubbles can extravasate intact is then demonstrated upon different delivery avenues with real-time acoustic and visual observations in tumour-affected functional circulation at the microscale. An ultrasound-stimulated in situ conversion of microbubbles to nanobubbles is studied and compared to passive and ultrasound-mediated delivery of injected nanobubbles, with acute vascular events from ultrasound-stimulation of nanobubbles being visualized for the first time.Developing a tool for further examination of nanobubbles, their scattering is then systematically investigated at high frequencies with a view to establishing imaging schemes based on their physical behaviour. Pressure-calibrated amplitude modulation is employed on a commercial pre-clinical array system, resulting in enhanced contrast-to-tissue ratios onthe order of 10 dB in a phantom and in vivo. Collectively, the developments achieved in this thesis aim to extend bubble-mediated approaches through the integration of nanomedicine and ultrasound.

ISBN: 9798522944575Subjects--Topical Terms:

518360
Biophysics.
Subjects--Index Terms:

Contrast Agent

Nonlinear Nanobubble Behaviour for Vascular and Extravascular Applications.
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650 4 $a Cancer therapies. $3 3557730
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