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imaging of targeted lipid microbubbles using third harmonic generation microscopy.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	imaging of targeted lipid microbubbles using third harmonic generation microscopy./
作者:	Harpel, Kaitlin G.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2016,
面頁冊數:	46 p.
附註:	Source: Masters Abstracts International, Volume: 78-01.
Contained By:	Masters Abstracts International78-01.
標題:	Biomedical engineering. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10118301
ISBN:	9781339796505

imaging of targeted lipid microbubbles using third harmonic generation microscopy.
Harpel, Kaitlin G.

imaging of targeted lipid microbubbles using third harmonic generation microscopy. - Ann Arbor : ProQuest Dissertations & Theses, 2016 - 46 p.

Source: Masters Abstracts International, Volume: 78-01.

Thesis (M.S.)--The University of Arizona, 2016.

This item must not be added to any third party search indexes.

The use of receptor-targeted lipid microbubbles imaged by ultrasound is an innovative method of detecting and localizing disease. However, since ultrasound requires a medium between the transducer and the object being imaged, it is impractical to apply to an exposed surface in a surgical setting where sterile fields need be maintained. Additionally, the application of an ultrasound gel to the imaging surface may cause the bubbles to collapse. Multiphoton microscopy (MPM) is an emerging tool for accurate imaging of tissues and cells with high resolution and contrast. We have recently developed a novel method for detecting targeted microbubble adherence to the upregulated plectin-receptor on pancreatic tumor cells using MPM. Specifically, the third-harmonic generation response can be used to detect bound microbubbles to various cell types presenting MPM as an alternative and useful imaging method. This is an interesting technique that can potentially be translated as a diagnostic tool for the early detection of cancer and inflammatory disorders.

ISBN: 9781339796505Subjects--Topical Terms:

535387
Biomedical engineering.
Subjects--Index Terms:

Confocal microscopy

imaging of targeted lipid microbubbles using third harmonic generation microscopy.
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500 $a Source: Masters Abstracts International, Volume: 78-01.
500 $a Publisher info.: Dissertation/Thesis.
500 $a Advisor: Matsunaga, Terry O.
502 $a Thesis (M.S.)--The University of Arizona, 2016.
506 $a This item must not be added to any third party search indexes.
506 $a This item must not be sold to any third party vendors.
520 $a The use of receptor-targeted lipid microbubbles imaged by ultrasound is an innovative method of detecting and localizing disease. However, since ultrasound requires a medium between the transducer and the object being imaged, it is impractical to apply to an exposed surface in a surgical setting where sterile fields need be maintained. Additionally, the application of an ultrasound gel to the imaging surface may cause the bubbles to collapse. Multiphoton microscopy (MPM) is an emerging tool for accurate imaging of tissues and cells with high resolution and contrast. We have recently developed a novel method for detecting targeted microbubble adherence to the upregulated plectin-receptor on pancreatic tumor cells using MPM. Specifically, the third-harmonic generation response can be used to detect bound microbubbles to various cell types presenting MPM as an alternative and useful imaging method. This is an interesting technique that can potentially be translated as a diagnostic tool for the early detection of cancer and inflammatory disorders.
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653 $a Plectin1 receptor
653 $a Third harmonic generation
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