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The Role of Cadherin 4 in the Assembly of Retinal Circuits.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	The Role of Cadherin 4 in the Assembly of Retinal Circuits./
作者:	Olguin, Aline Giselle Rangel.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2020,
面頁冊數:	53 p.
附註:	Source: Masters Abstracts International, Volume: 82-10.
Contained By:	Masters Abstracts International82-10.
標題:	Neurons. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28384044
ISBN:	9798708710178

The Role of Cadherin 4 in the Assembly of Retinal Circuits.
Olguin, Aline Giselle Rangel.

The Role of Cadherin 4 in the Assembly of Retinal Circuits. - Ann Arbor : ProQuest Dissertations & Theses, 2020 - 53 p.

Source: Masters Abstracts International, Volume: 82-10.

Thesis (M.Sc.)--McGill University (Canada), 2020.

This item must not be sold to any third party vendors.

Neurons grow axons and dendrites into target regions where they face hundreds of proximate potential synaptic partners but connect with only a select few. This selectivity is critical for wiring patterns and circuit computations but how it arises is unclear. In the retina, a specialized neuropil called the inner plexiform layer (IPL) organizes the processes of ~40 types of retinal ganglion cells (RGCs) and their ~100 types of interneuron inputs. The IPL is multi-layered, each sublayer enriches the processes of interneuron-RGC partners and is critical for the assembly of feature detecting retinal circuits. Previous work indicates that members of the cadherin superfamily (Cdh) play a crucial role in layer-specific targeting. In this thesis, I show that Cdhs are expressed in distinct patterns across RGC subtypes and start the characterization of Cdh4, also known as retina Cdh. Using genetically encoded markers I show that Cdh4 expression is restricted to interneurons and RGCs that project to upper layers of the IPL, and horizontal cells. These anatomical studies suggest that Cdh4 targets neurons to the OFF regions of the IPL. Taken together, this thesis supports the idea that neurons might use a Cdh code to position their neuropil to achieve synapse selectivity and the existence of an adhesive code.

ISBN: 9798708710178Subjects--Topical Terms:

588699
Neurons.

The Role of Cadherin 4 in the Assembly of Retinal Circuits.
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506 $a This item must not be sold to any third party vendors.
520 $a Neurons grow axons and dendrites into target regions where they face hundreds of proximate potential synaptic partners but connect with only a select few. This selectivity is critical for wiring patterns and circuit computations but how it arises is unclear. In the retina, a specialized neuropil called the inner plexiform layer (IPL) organizes the processes of ~40 types of retinal ganglion cells (RGCs) and their ~100 types of interneuron inputs. The IPL is multi-layered, each sublayer enriches the processes of interneuron-RGC partners and is critical for the assembly of feature detecting retinal circuits. Previous work indicates that members of the cadherin superfamily (Cdh) play a crucial role in layer-specific targeting. In this thesis, I show that Cdhs are expressed in distinct patterns across RGC subtypes and start the characterization of Cdh4, also known as retina Cdh. Using genetically encoded markers I show that Cdh4 expression is restricted to interneurons and RGCs that project to upper layers of the IPL, and horizontal cells. These anatomical studies suggest that Cdh4 targets neurons to the OFF regions of the IPL. Taken together, this thesis supports the idea that neurons might use a Cdh code to position their neuropil to achieve synapse selectivity and the existence of an adhesive code.
520 $a Les neurones developpent leurs axones et leurs dendrites vers des regions ou ils trouvent des centaines de partenaires synaptiques potentiels mais ne se connectent qu'a quelques privilegies. Cette selectivite est essentielle pour etablir des motifs de connexion fonctionnels, mais la facon dont se produisent est encore inconnue. Dans la retine, un neuropile specialise appele couche de plexiforme interne (CPI) organise les neurites de ~ 40 types de cellules ganglionnaires (CG) et leurs ~ 100 types d'interneurones constituent leurs entre d'information neuronale. Le CPI est une structure a 5 couches, ou chaque couche est enrichie pour certaines pairs d'interneurone-CG. Cette organisation est essentielle pour l'assemblage des circuits retiniens qui detectent des caracteristiques visuelles. Des etudes anterieures indiquent que les membres de la superfamille des cadherines (Cdh) jouent un role crucial en dirigeant les dendrites vers des couches specifiques de le CPI. Dans cette these, je demontre que les Cdhs ont des motifs d'expression distinct parmi les types de CGs et debute la caracterisation de Cdh4, egalement connue sous le nom de cadherine retinienne. En utilisant des marqueurs genetiquement codes, je montre que l'expression de Cdh4 est limitee aux interneurones et aux RGC qui se projettent vers les couches superieures de la CPI, et les cellules horizontales. Ces etudes anatomiques suggerent que Cdh4 cible les neurones vers la region OFF de la CPI. Dans l'ensemble, cette these soutient la possibilite que les neurones forment des synapses selectives en utilisant un code Cdhs pour positionner leurs neurites et qu'il existe un code adhesif.
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